期刊
LAB ON A CHIP
卷 16, 期 17, 页码 3362-3373出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6lc00562d
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资金
- Engineering and Physical Science Research Council (EPSRC) via the Centre for Innovative Manufacturing in Additive Manufacturing
- EPSRC [EP/I033335/1, EP/I033335/2] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I033335/1, EP/I033335/2] Funding Source: researchfish
The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100-500 mu m) means that these devices were capable of handling a wide range of concentrations (9 mu M-38 mM), and are ideally suited to both analyte detection and process optimisation. This ability to tailor the chip design and its integrated features as a direct result of the reaction being assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device and reaction. As a result of the information gained in this investigation, we are able to report the first instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded optical fibres capable of performing UV-vis spectroscopy directly inside micro channels.
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