Static first-minute-frame (FMF) PET imaging after 18F-labeled amyloid tracer injection is correlated to [18F]FDG PET in patients with primary progressive aphasia

Objective: To study the correlation between a static PET image of the first-minute-frame (FMF) acquired with 18F-labeled amyloidbinding radiotracers and brain [18F]FDG PET in patients with primary progressive aphasia (PPA).Material and methods: The study cohort includes 17 patients diagnosed with PPA with the following distribution: 9 nonfluent variant PPA, 4 logopenic variant PPA, 1 semantic variant PPA, 3 unclassifiable PPA. Regional SUVRs are extracted from FMFs and their corresponding [18F]FDG PET images and Pearson's correlation coefficients are calculated.Results: SUVRs of both images show similar patterns of regional cerebral alterations. Intrapatient correlation analyses result in a mean coefficient of r = .94 & PLUSMN; .06. Regional interpatient correlation coefficients of the study cohort are greater than 0.81. Radiotracerspecific and variant-specific subcohorts show no difference in the similarity between the images.Conclusions: The static FMF could be a valid alternative to dynamic early-phase amyloid PET proposed in the literature, and a neurodegeneration biomarker for the diagnosis and classification of PPA in amyloid PET studies.& COPY; 2023 Sociedad Espanola de Medicina Nuclear e Imagen Molecular. Published by Elsevier Espan & SIM;a, S.L.U. All rights reserved.

Automated summary

This study aims to investigate the correlation between static PET images and brain [18F]FDG PET. The results demonstrate that the SUVRs of both images exhibit similar regional cerebral alterations, which can serve as a biomarker for the diagnosis and classification of PPA.