☆ 4.7 Review

Breaking Barriers in Eye Treatment: Polymeric Nano-Based Drug-Delivery System for Anterior Segment Diseases and Glaucoma

POLYMERS (2023)

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Article Ophthalmology

Bimatoprost Implant Biodegradation in the Phase 3, Randomized, 20-Month ARTEMIS Studies

Robert N. Weinreb et al.

Summary: This study evaluated the degradation time of a new biodegradable bimatoprost implant and found individual variability among patients. Clinically significant degradation of the implant was observed in the majority of patients by 12 months. Future clinical studies will further investigate the optimal timing for implant degradation and re-administration.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2023)

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Review Chemistry, Inorganic & Nuclear

Cyclodextrin-based ocular drug delivery systems: A comprehensive review

Qiuxiang Wang et al.

Summary: Cyclodextrin (CD), a cyclic oligosaccharide, is a promising pharmaceutical excipient due to its ability to form complexes with small molecules and polymers. Over the past two decades, CD-based ocular drug delivery systems have rapidly developed, offering excellent biocompatibility, safety, and stability. This review discusses recent progress in CD-based ocular drug delivery systems, including drug/CD complexes, CD-based nanocarriers and microcarriers, CD-based hydrogels, and CD-based inserts. Additionally, the methods for ocular safety evaluation and patents and clinical trials for CD-based ocular drug delivery systems are systematically summarized.

COORDINATION CHEMISTRY REVIEWS (2023)

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Article Chemistry, Medicinal

Chitosan and Hyaluronic Acid Nanoparticles as Vehicles of Epoetin Beta for Subconjunctival Ocular Delivery

Beatriz Silva et al.

Summary: This study investigates the delivery of EPO beta to the eye through subconjunctival administration of chitosan-hyaluronic acid-EPO beta nanoparticles. The results show that these nanoparticles can efficiently deliver EPO beta into the retina without adverse effects. This nanoformulation could be a promising tool for treating retinopathies.

MARINE DRUGS (2022)

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Article Medicine, Research & Experimental

In Situ Gelling Electrospun Ocular Films Sustain the Intraocular Pressure-Lowering Effect of Timolol Maleate: In Vitro, Ex Vivo, and Pharmacodynamic Assessment

Ioannis I. Andreadis et al.

Summary: Intraocular pressure reduction regimens for glaucoma often involve eye drops, which have limitations such as short residence time and reduced patient compliance. In situ gelling nanofiber films were developed for ocular delivery of timolol maleate, showing sustained IOP-lowering effects and improved drug release compared to conventional eye drops.

MOLECULAR PHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Validation of a Rapid and Easy-to-Apply Method to Simultaneously Quantify Co-Loaded Dexamethasone and Melatonin PLGA Microspheres by HPLC-UV: Encapsulation Efficiency and In Vitro Release

Marco Brugnera et al.

Summary: This paper discusses the development and validation of a rapid method for the quantification of two neuroprotective agents in biodegradable PLGA microspheres. The method allows for the simultaneous determination of the two agents and has potential value in the treatment of glaucoma.

PHARMACEUTICS (2022)

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Review Medicine, General & Internal

Considerations for Polymers Used in Ocular Drug Delivery

Megan M. Allyn et al.

Summary: Age-related eye diseases are becoming more common, and the use of polymers for ocular drug delivery is a promising option. This article provides an overview of synthetic and biopolymer materials used in ocular delivery, their benefits, synthesis methods, and administration techniques. The challenges of bringing these innovations to the clinic are also discussed.

FRONTIERS IN MEDICINE (2022)

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Article Ophthalmology

Intraocular Pressure-Lowering Efficacy of a Sustained-Release Bimatoprost Implant in Dog Eyes Pretreated with Selective Laser Trabeculoplasty

Corine Ghosn et al.

Summary: The study aimed to assess the IOP-lowering effect of a biodegradable bimatoprost implant after selective laser trabeculoplasty (SLT). The results showed that the bimatoprost implant effectively lowered IOP in eyes pretreated with SLT, regardless of response to SLT.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2022)

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Article Biochemistry & Molecular Biology

Fabrication of anti-oxidant curcumin loaded ceria nanoclusters for the novel delivery system to prevention of selenite-induced cataract therapy in alleviating diabetic cataract

Yanzhang Liu et al.

Summary: Diabetic cataract is a major cause of visual impairment for diabetic patients. Current drug delivery approaches and pharmacologic interventions for controlling diabetic cataract progression are limited, especially non-invasive strategies involving eye drops. This study developed a novel nanoformulation using antioxidant curcumin and cerium oxide nanoparticles to treat diabetic cataract complications by improving redox and anti-glycation potential. The nanoformulation exhibited effective antioxidant and anti-glycation properties in protecting lens epithelial cells and showed no toxicity in vivo.

PROCESS BIOCHEMISTRY (2022)

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Article Engineering, Biomedical

Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye

Yi Han et al.

Summary: The development of a novel temperature-sensitive hydrogel can improve the solubility and retention time of drugs on the ocular surface, providing an effective treatment for dry eye.

BIOACTIVE MATERIALS (2022)

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Review Biochemistry & Molecular Biology

Recent Advances in Poly(α-L-glutamic acid)-Based Nanomaterials for Drug Delivery

Yu Zhang et al.

Summary: This work discusses the research progress and applications of poly(alpha-L-glutamic acid) (PGA) and its nanomaterials in drug delivery. It is found that PGA has biocompatibility and biodegradability, making it a promising candidate for drug delivery systems.

BIOMOLECULES (2022)

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Article Ophthalmology

Clinical efficacy of 0.05% cyclosporine nano-emulsion in the treatment of dry eye syndrome associated with meibomian gland dysfunction

Yeon Ji Jo et al.

Summary: The use of cyclosporine and nano-cyclosporine in treating DES with MGD patients showed significant improvement compared to the control group. The nano-cyclosporine group exhibited more statistically improved CI and CS at 4 weeks, especially LLT at 4, 8, and 12 weeks compared to the conventional cyclosporine group.

INTERNATIONAL JOURNAL OF OPHTHALMOLOGY (2022)

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Article Medicine, Research & Experimental

Peptide-Modified Gemini Surfactants as Delivery System Building Blocks with Dual Functionalities for Glaucoma Treatment: Gene Carriers and Amyloid-Beta (Aβ) Self-Aggregation Inhibitors

Lokesh Narsineni et al.

Summary: This study explores the potential of using cell adhesion peptide-gemini surfactants as building blocks for gene carrier nanoparticles for glaucoma treatment. The surfactants showed inhibitory effects on the aggregation of Afi40 peptide and could protect retinal ganglion cells (RGCs) from neurodegeneration in glaucoma.

MOLECULAR PHARMACEUTICS (2022)

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Review Biochemical Research Methods

Dendrimer-based drug delivery systems: history, challenges, and latest developments

Juan Wang et al.

Summary: This article provides an overview of the history and properties of dendrimers, as well as the latest developments in their applications as drug delivery systems. The review focuses on active drug release strategies, size-adaptive and charge reversal dendrimer delivery systems, and bulk and micro/nano dendrimer gel delivery systems.

JOURNAL OF BIOLOGICAL ENGINEERING (2022)

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Review Biochemistry & Molecular Biology

Nanoparticles in ocular applications and their potential toxicity

Cao Yang et al.

Summary: Nanotechnology has rapidly developed and been widely applied in ocular disease therapy. Nano-drug delivery systems show strong biocompatibility and efficiency, but also potential toxicity, which needs to be evaluated through experiments for safety verification.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Article Chemistry, Applied

N-acetylcysteine functionalized chitosan oligosaccharide-palmitic acid conjugate enhances ophthalmic delivery of flurbiprofen and its mechanisms

Yuhui Sheng et al.

Summary: An N-acetylcysteine functionalized chitosan oligosaccharide-palmitic acid conjugate (NAC-COS-PA) was synthesized for enhanced transocular drug delivery. The conjugate exhibited good biocompatibility and increased drug permeation. In vivo studies showed that NAC-COS-PA-FB had superior anti-inflammatory efficacy compared to other nanomicelles and solution.

CARBOHYDRATE POLYMERS (2022)

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Article Pharmacology & Pharmacy

Rebamipide liposome as an effective ocular delivery system for the management of dry eye disease

Han Qiao et al.

Summary: In this study, RBM liposomal eye drops were designed and optimized for the treatment of dry eye disease (DED). The RBM liposomes showed better stability, slow-release rate, and longer residence time on the ocular surface compared to suspensions. They reduced the drug dose and irritation to the ocular surface while maintaining the same efficacy and increasing the concentration in the cornea and aqueous humor.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Article Medicine, Research & Experimental

Optimization and Characterization of Low-Molecular-Weight Chitosan-Coated Baicalin mPEG-PLGA Nanoparticles for the Treatment of Cataract

Nan Li et al.

Summary: The potential effectiveness of low-molecular-weight chitosan-coated nanoparticles for the treatment of cataract was evaluated in this study. The optimized nanoparticles showed improved precorneal residence time and sustained drug release, effectively managing cataract symptoms.

MOLECULAR PHARMACEUTICS (2022)

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Article Polymer Science

Hydrogels on the Base of Modified Chitosan and Hyaluronic Acid Mix as Polymer Matrices for Cytostatics Delivery

Regina Vildanova et al.

Summary: This study developed biodegradable polysaccharide hydrogel matrices that can enhance the therapeutic effects of cytostatic drugs by prolonging drug action, reducing toxicity, and providing additional biological activity. The interaction between N-succinyl chitosan and hyaluronic acid dialdehyde resulted in the formation of azomethine bonds. The rheological properties of the hydrogels and the molecular weight of N-succinyl chitosan influenced the drug release behavior. The formulation with the highest molecular weight of N-succinyl chitosan and mitomycin C showed the most promising results for medical application.

GELS (2022)

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Article Biochemistry & Molecular Biology

Exploring the Impact of Morphology on the Properties of Biodegradable Nanoparticles and Their Diffusion in Complex Biological Medium

Roxane Ridolfo et al.

Summary: The morphology and surface chemistry of nanoparticles play a crucial role in their efficacy in therapeutic applications, with high aspect ratio shapes showing enhanced properties in terms of cell uptake, drug release, and diffusion.

BIOMACROMOLECULES (2021)

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Article Engineering, Biomedical

New antiglaucomatous agent for the treatment of open angle glaucoma: Polymeric inserts for drug release and in vitro and in vivo study

Aina Liz A. Cesar et al.

Summary: A benzamidine derivative from diminazene was tested for treating primary open-angle glaucoma. Mucoadhesive polymeric inserts prepared using chitosan and chondroitin sulfate were found to effectively control intraocular pressure for at least 3 weeks, demonstrating promising results for glaucoma treatment.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

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Article Ophthalmology

Safety of KPI-121 Ophthalmic Suspension 0.25% in Patients With Dry Eye Disease: A Pooled Analysis of 4 Multicenter, Randomized, Vehicle-Controlled Studies

Michael Korenfeld et al.

Summary: The safety of KPI-121 0.25%, an ophthalmic nanoparticle suspension of loteprednol etabonate, was evaluated in patients with dry eye disease, with instillation site pain being the main adverse event reported and low incidence of elevated intraocular pressure noted.

CORNEA (2021)

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Article Ophthalmology

Prolonged use of nitric oxide donor sodium nitroprusside induces ocular hypertension in mice

Chunchun Hu et al.

Summary: The study found that sustained use of the NO donor sodium nitroprusside initially reduced intraocular pressure (IOP) but later surprisingly caused IOP elevation, which could not be reversed by drug withdraw but could be reversed by the antioxidant MnTMPyP application. The elevation and normalization of IOP corresponded with changes in protein nitration levels in mouse conventional outflow tissue, suggesting that prolonged use of NO donors may lead to outflow tissue damage by protein nitration. MnTMPyP showed protective effects against nitrative damage and could be considered for co-application with NO donors.

EXPERIMENTAL EYE RESEARCH (2021)

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Review Pharmacology & Pharmacy

Size, shape, charge and stealthy surface: Carrier properties affect the drug circulation time in vivo

Jinwei Di et al.

Summary: The properties of drug carriers, such as size, shape, surface charge, and surface modification, play a crucial role in their circulation time, metabolic behavior and biodistribution in vivo. Attention should be paid to these properties when designing drug delivery systems to ensure sufficient in vivo circulation time to reach the target site.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Nanoscience & Nanotechnology

Design, Optimization, and Characterization of Lactoferrin-Loaded Chitosan/TPP and Chitosan/Sulfobutylether-beta-cyclodextrin Nanoparticles as a Pharmacological Alternative for Keratoconus Treatment

Ruben Varela-Fernandez et al.

Summary: This research focused on the design, optimization, and characterization of two types of chitosan-based nanoparticles for the delivery of a protein drug, lactoferrin. The nanoparticles were prepared via the ionotropic gelation technique and showed positive zeta-potential values. Lactoferrin was effectively incorporated into the nanoparticles, resulting in enhanced, prolonged, and controlled release profiles.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Ophthalmology

Angiotensin Receptor Blockers in cyclodextrin nanoparticle eye drops: Ocular pharmacokinetics and pharmacologic effect on intraocular pressure

Laura Lorenzo-Soler et al.

Summary: The study found that nanoparticle eye drops containing ARBs effectively reduced intraocular pressure in rabbits and showed potential for delivering drug concentrations to intraocular tissues.

ACTA OPHTHALMOLOGICA (2021)

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Article Biochemistry & Molecular Biology

Efficient Synthesis of Folate-Conjugated Hollow Polymeric Capsules for Accurate Drug Delivery to Cancer Cells

Wenliang Song et al.

Summary: This study presents an efficient and systematic approach to synthesize bioapplicable porous hollow polymeric capsules, offering potential applications in drug delivery. By converting hydroxyl groups on the surface to carboxyl groups, biomolecules can be covalently decorated on the organic capsules. The research results show that these organic capsules have potential applications in drug encapsulation efficiency and release.

BIOMACROMOLECULES (2021)

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Article Engineering, Biomedical

Endogenous dual stimuli-activated NO generation in the conventional outflow pathway for precision glaucoma therapy

Wenpei Fan et al.

Summary: The study introduced deep cornea penetrating biodegradable hollow mesoporous organosilica (HOS) nanocapsules for the efficient co-delivery of hydrophobic JS-K and hydrophilic L-Arginine to induce significant IOP reduction in various glaucoma mouse models. This novel approach not only develops an endogenous stimuli-responsive NO nanotherapeutic, but also aims to establish a versatile, non-invasive, and efficacious treatment paradigm for precision glaucoma therapy.

BIOMATERIALS (2021)

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Article Polymer Science

The use of TPGS in drug delivery systems to overcome biological barriers

Marcela Tavares Luiz et al.

Summary: Nanotechnology has been utilized in medicine to improve disease treatment, but overcoming biological barriers is essential for enhancing the permeation of nanomedicines. Surface modifications, such as using permeation enhancers and specific ligands, have been widely investigated to improve the penetration of nanomedicines through barriers.

EUROPEAN POLYMER JOURNAL (2021)

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Article Ophthalmology

Comparative evaluation of once-daily and twice-daily dosing of topical bromfenac 0.09%: aqueous pharmacokinetics and clinical efficacy study

Jeewan S. Titiyal et al.

Summary: The study evaluated the aqueous pharmacokinetics of topical bromfenac 0.09% and compared the clinical outcomes of once- and twice-daily dosing in phacoemulsification. Results showed that while single-dose topical bromfenac did not maintain therapeutic aqueous concentration over 24 hours, cumulative effect was observed with repeated dosing. The clinical efficacy of once-daily and twice-daily dosing was comparable.

JOURNAL OF CATARACT AND REFRACTIVE SURGERY (2021)

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Article Chemistry, Medicinal

Preparation and Characterization of Tacrolimus-Loaded SLNs in situ Gel for Ocular Drug Delivery for the Treatment of Immune Conjunctivitis

Kexin Sun et al.

Summary: This study developed a novel in situ gel of tacrolimus-loaded SLNs for ocular drug delivery. Experiment results demonstrated that TAC SLNs-ISG showed sustained drug release characteristics and had good pharmacodynamics compared to eye drops and SLNs, indicating the potential to be an ideal ocular drug delivery system.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Article Multidisciplinary Sciences

Positive-charge tuned gelatin hydrogel-siSPARC injectable for siRNA anti-scarring therapy in post glaucoma filtration surgery

Yong Yao Chun et al.

Summary: The study presents a biocompatible injectable gelatin-based hydrogel with positive-charge tuned surface charge as an effective platform for siRNA protection and delivery. Experimental results demonstrate the effectiveness of this hydrogel in delivering siSPARC for anti-fibrotic treatment, showing sustained cellular internalization and effective gene silencing with excellent biocompatibility. This charge tunable hydrogel delivery system is simple to fabricate and highly scalable, suggesting strong translational potential for siRNA delivery and epigenetic silencing therapy.

SCIENTIFIC REPORTS (2021)

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Article Pharmacology & Pharmacy

Topical Bimatoprost Insert for Primary Open-Angle Glaucoma and Ocu- lar Hypertension Treatment- A Phase II Controlled Study

Francine Rubiao et al.

Summary: The study compared the efficacy and safety of bimatoprost inserts with bimatoprost eye drops in patients with POAG and OH, showing similar results during the three-week follow-up. The majority of participants preferred using inserts over eye drops.

CURRENT DRUG DELIVERY (2021)

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Article Chemistry, Multidisciplinary

Drug-Free, Nonsurgical Reduction of Intraocular Pressure for Four Months after Suprachoroidal Injection of Hyaluronic Acid Hydrogel

J. Jeremy Chae et al.

Summary: The study developed a drug-free, nonsurgical method to lower intraocular pressure in glaucoma patients, using hyaluronic acid hydrogel injections to stabilize IOP reduction for 4 months. Safety assessment showed good tolerance of the treatment, which can effectively treat glaucoma.

ADVANCED SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of cutaneous fungal infections Ke

Ke Peng et al.

Summary: Fungal infections are a global issue affecting millions of individuals, with conventional treatments often proving ineffective due to low drug bioavailability and drug resistance. Amphotericin B (AmB) loaded dissolving microneedle patches were introduced for localized and long-acting intradermal delivery to treat cutaneous fungal infections, demonstrating significant inhibition and killing of Candida albicans. Moreover, pharmacokinetic studies showed lower systemic exposure and reduced systemic side effects compared to intravenous injection, highlighting the potential of this novel drug delivery system.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Pharmacology & Pharmacy

Alginate nanoparticles as ocular drug delivery carriers

Sogol Kianersi et al.

Summary: The eye is the most susceptible organ of the body, requiring a special drug delivery system to improve drug bioavailability and reduce dosing frequency. By preparing alginate nanoparticles and conducting coating modification, sustained drug release, increased drug adhesion to ocular tissue, and decreased need for duplicate treatment can be achieved.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Pharmacology & Pharmacy

Efficacy, Safety, and Tolerability of a Novel Cyclosporine, a Formulation for Dry Eye Disease: A Multicenter Phase II Clinical Study

Wen-Yan Peng et al.

Summary: This study compared the efficacy of a novel cyclosporine formulation, CyclAGel, with the positive control Restasis for dry eye disease. The findings showed consistent improvements with CyclAGel in key dry eye symptoms compared to Restasis, with all treatment groups demonstrating low ocular-related adverse events and no serious drug-related adverse events.

CLINICAL THERAPEUTICS (2021)

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Review Biochemistry & Molecular Biology

Role of Retinal Amyloid-β in Neurodegenerative Diseases: Overlapping Mechanisms and Emerging Clinical Applications

Liang Wang et al.

Summary: Accumulation of A beta in the retina is associated with neurodegenerative disorders such as Alzheimer's disease, glaucoma, and age-related macular degeneration, leading to progressive retinal neurodegeneration, increased cerebral A beta accumulation, and decline in cognition and vision. Retinal A beta pathology occurs before irreversible neurodegeneration, highlighting its potential for early disease detection and intervention. Targeting A beta-associated pathological pathways may provide new therapeutic options for preserving cognition and vision in these disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Pharmacology & Pharmacy

Comparative Analysis of Morphological and Release Profiles in Ocular Implants of Acetazolamide Prepared by Electrospinning

Mariana Morais et al.

Summary: The study aims to develop a novel polymeric implant for sustained release of acetazolamide to improve patient compliance. Uncoated implants produced by electrospinning and coated implants with different drug release rates were prepared, with the Luwax EVA 3-coated implant showing considerably slower release of acetazolamide. This innovative approach offers sustained drug release compared to other ocular drug delivery systems.

PHARMACEUTICS (2021)

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Article Engineering, Biomedical

Targeted delivery of LM22A-4 by cubosomes protects retinal ganglion cells in an experimental glaucoma model

Yue Ding et al.

Summary: Glaucoma is a major cause of irreversible blindness worldwide, associated with elevated intraocular pressure and progressive loss of RGCs. Targeting neurotrophic support to injured neurons may be a better neuroprotective strategy. Using nano-carriers for targeted drug delivery shows promising results in glaucoma treatment.

ACTA BIOMATERIALIA (2021)

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Article Biotechnology & Applied Microbiology

Polydopamine nanoparticles attenuate retina ganglion cell degeneration and restore visual function after optic nerve injury

Xiaotong Lou et al.

Summary: The study suggests that a polydopamine-based nanoplatform can protect retina ganglion cells from oxidative damage, reduce inflammatory response, maintain retinal function, and potentially improve cell survival by altering gene expression through transcriptome analysis. Additionally, the nanoplatform can deliver neuroprotective drugs to synergistically promote cell survival and axon regeneration.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Ophthalmology

Optimization and Characterization of Brimonidine Tartrate Nanoparticles-loaded In Situ Gel for the Treatment of Glaucoma

Pankaj Kumar Sharma et al.

Summary: The study aimed to develop BRT-PLGA-TPGS nanoparticles in a thermosensitive in situ gel for improved mucoadhesive properties and drug holding capacity in the management of glaucoma. The optimized formulation showed enhanced transcorneal permeability, sustained drug release, and greater reduction in intraocular pressure compared to marketed eye drops. Incorporating the nanoparticles into the gel matrix provided a promising approach for effective glaucoma treatment.

CURRENT EYE RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Why chitosan could be apt candidate for glaucoma drug delivery - An overview

B. N. Kumara et al.

Summary: This article highlights the impact of glaucoma on most people worldwide, discusses drug delivery issues in glaucoma treatment, and explores the application value and future prospects of chitosan in this field.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Chemistry, Multidisciplinary

Topical tacrolimus nanocapsules eye drops for therapeutic effect enhancement in both anterior and posterior ocular inflammation models

Leslie Rebibo et al.

Summary: The study confirmed the stability and efficacy of tacrolimus-loaded nanocapsules in ocular applications. NCs showed superior performance in eye instillation, leading to high levels of tacrolimus retention in the eye and low plasma concentrations. Additionally, the developed delivery system achieved a significant decrease in inflammatory markers in murine models of keratitis and experimental autoimmune uveitis, demonstrating clinical and histological efficacy.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Chemistry, Medicinal

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

Bharti Gupta et al.

Summary: Low aqueous solubility and poor bioavailability are major obstacles in drug development, especially for BCS class II drugs in ocular drug delivery systems. Cellulosic polymers show promise in enhancing the bioavailability of these drugs due to their hydrophilic nature and tunable properties.

PHARMACEUTICALS (2021)

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Review Pharmacology & Pharmacy

Nanoemulsions as Ophthalmic Drug Delivery Systems

Rasha Khalid Dhahir et al.

Summary: Nanoemulsions are liquid-in-liquid dispersion with a droplet size of about 100 nm, characterized by transparent appearance, high bioavailability, and extended shelf life. They are mainly composed of oil, water, surfactant, and cosurfactant and can be prepared by high- and low-energy methods.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Pharmacology & Pharmacy

Intravitreal Polymeric Nanocarriers with Long Ocular Retention and Targeted Delivery to the Retina and Optic Nerve Head Region

Vijayabhaskarreddy Junnuthula et al.

Summary: This study synthesized and characterized block copolymers that self-assembled into polymersomes and polymeric micelles, which showed stability and diffusibility in the vitreous and no cellular toxicity. Pharmacokinetic evaluation in rabbits showed prolonged half-lives and retention of these nanocarriers in the vitreous, making them promising for controlled and site-specific drug delivery in the posterior eye segment.

PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells

Henry T. Hsueh et al.

Summary: Glaucoma is the leading cause of irreversible blindness worldwide, with elevated intraocular pressure being a major risk factor. While current pharmaceutical interventions focus on lowering IOP, the progression of retinal ganglion cell degeneration may continue. This study explores a novel ion complexation approach for formulating microcrystals containing a protein kinase inhibitor, sunitinib, to enhance survival of RGCs with subconjunctival injection, providing sustained therapeutic effects.

PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Polyvinyl Alcohol/Chitosan Single-Layered and Polyvinyl Alcohol/Chitosan/Eudragit RL100 Multi-layered Electrospun Nanofibers as an Ocular Matrix for the Controlled Release of Ofloxacin: an In Vitro and In Vivo Evaluation

Shahla Mirzaeei et al.

Summary: A novel nanofiber insert was prepared using modified electrospinning method to enhance ocular residence time of OFX with sustained release. The nanofibers were cross-linked and studied for OFX release through in vitro and in vivo methods, demonstrating antimicrobial efficacy and sustained drug release in ocular delivery systems.

AAPS PHARMSCITECH (2021)

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Article Nanoscience & Nanotechnology

Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy

Michael P. Vincent et al.

Summary: The study presents a targeted drug delivery strategy for treating glaucoma by optimizing FLT4 receptor-targeting ligands, leading to improved treatment outcomes by enhancing uptake by SC cells and reducing uptake by off-target vascular endothelial cells. This approach significantly reduces intraocular pressure and sustains the effect for a longer period of time compared to conventional treatments. Confocal microscopy confirms the localization of nanocarriers to SC within 1 hour of administration, showing the potential for targeted drug delivery in glaucoma therapy.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Applied

Hyaluronic acid in ocular drug delivery

Xiaodan Zhang et al.

Summary: Hyaluronic acid, a naturally-occurring polysaccharide in ophthalmic tissues, has a wide range of applications in the treatment of ocular diseases. Recent advances in HA-based drug delivery systems have shown the importance of rational selection of molecular weight and amount of HA for diverse delivery systems.

CARBOHYDRATE POLYMERS (2021)

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Article Ophthalmology

Phase Transition Microemulsion of Brimonidine Tartrate for Glaucoma Therapy: Preparation, Characterization and Pharmacodynamic Study

Nivedita Gautam et al.

Summary: The study aimed to formulate brimonidine tartrate loaded phase transition microemulsions (PMEs) for the effective treatment of glaucoma. The optimized PMEs showed small globule size, favorable physicochemical properties, sustained release, enhanced corneal permeation, and greater reduction in intraocular pressure compared to the marketed formulation (MF). PMEs offer a promising approach for sustained drug release, enhanced bioavailability, and patient compliance in ocular drug delivery.

CURRENT EYE RESEARCH (2021)

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Article Ophthalmology

Formulation of carteolol chitosomes for ocular delivery: formulation optimization, ex-vivo permeation, and ocular toxicity examination

Ameeduzzafar Zafar et al.

Summary: The study demonstrated that NIM coated with CH could enhance the ocular residence time of CT. The optimized formulation showed sustained drug release, improved bio-adhesion, and higher transcorneal permeation compared to traditional systems. The histopathology and HET-CAM results indicated no structural damage or bleeding, showing good stability for potential clinical use.

CUTANEOUS AND OCULAR TOXICOLOGY (2021)

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Review Chemistry, Multidisciplinary

Ocular drug delivery to the anterior segment using nanocarriers: A mucoadhesive/mucopenetrative perspective

Ridhdhi S. Dave et al.

Summary: There is a growing demand for effective treatments for ocular conditions, with topical administration being the preferred method despite its drawbacks. Nanoparticles with tunable mucoadhesion and/or mucopenetration show potential to overcome these drawbacks and improve ocular bioavailability, reduce toxicity, and increase ocular retention. Recent advances in developing nanocarriers with tunable mucoadhesion and mucopenetration for drug delivery to the eye are highlighted in the current review.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Nanoscience & Nanotechnology

Combinatorial therapeutic drug delivery of riboflavin and dexamethasone for the treatment of keratoconus affected corneas of mice: Ex vivo permeation and hemolytic toxicity

Na Wo et al.

Summary: This study aimed to formulate a thermoreversible gel containing riboflavin and dexamethasone for the treatment of keratoconus. The gel was evaluated for various parameters and showed safe and effective use of riboflavin and dexamethasone in treating the disease. Additionally, the gel demonstrated an increase in cell thickness in an in vitro model, highlighting its potential therapeutic benefits.

MICRO & NANO LETTERS (2021)

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Article Multidisciplinary Sciences

Stability and ocular biodistribution of topically administered PLGA nanoparticles

Sean Swetledge et al.

Summary: Polymeric nanoparticles loaded with lutein showed higher stability at low temperature with minimal lutein release and no significant morphological changes, but had decreased stability and increased lutein release at room temperature and high temperature. Additionally, these lutein-loaded nanoparticles demonstrated higher resistance to photodegradation compared to free lutein when exposed to ultraviolet light.

SCIENTIFIC REPORTS (2021)

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Article Ophthalmology

Retinal Protection by Sustained Nanoparticle Delivery of Oncostatin M and Ciliary Neurotrophic Factor Into Rodent Models of Retinal Degeneration

Jing-Yan Yang et al.

Summary: The study demonstrated the neuroprotective effects of sustained nanoparticle delivery of CNTF and OSM in animal models of retinal degeneration. This treatment showed significant RGC survival, preservation of vision, and photoreceptors compared to control groups. The findings suggest the potential therapeutic benefit of using nanoparticle-delivered neurotrophic factors in slowing down progressive retinal degenerative conditions like retinitis pigmentosa.

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY (2021)

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Article Pharmacology & Pharmacy

The Effect of a Triple Combination of Bevacizumab, Sodium Hyaluronate and a Collagen Matrix Implant in a Trabeculectomy Animal Model

Vanessa Andres-Guerrero et al.

Summary: The local delivery of bevacizumab combined with sodium hyaluronate and a collagen matrix can improve the outcome of trabeculectomy by reducing inflammation and cell infiltration, and increasing the survival rate of filtering blebs.

PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Novel cubosome based system for ocular delivery of acetazolamide

Hoda E. Teba et al.

Summary: Acetazolamide is an effective drug for glaucoma treatment, but has systemic side effects. Utilizing cubosomes as a novel nano-delivery system for acetazolamide eye drops can enhance drug permeability and therapeutic efficacy.

DRUG DELIVERY (2021)

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Article Pharmacology & Pharmacy

Wettability and contact angle affect precorneal retention and pharmacodynamic behavior of microspheres

Hanyu Liu et al.

Summary: The study developed a novel micro-interactive dual-functioning sustained-release delivery system (MIDFDS) using betaxolol hydrochloride and montmorillonite with ion exchange for the treatment of glaucoma. The MIDFDS showed better in vivo performance in terms of pharmacokinetics and pharmacodynamics compared to traditional methods, with a longer pre-corneal retention time. This dual-functioning sustained-release carrier demonstrated promising clinical implications with improved biocompatibility, potentially leading to enhanced compliance.

DRUG DELIVERY (2021)

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Article Materials Science, Biomaterials

A miRNA stabilizing polydopamine nano-platform for intraocular delivery of miR-21-5p in glaucoma therapy†

Chen Tan et al.

Summary: The study demonstrates that PDA/PEI NPs are effective carriers for miRNA in treating ocular hypertension and glaucoma, reducing intraocular pressure and reaching target tissues without causing inflammatory responses. This delivery strategy shows promise for treating primary open angle glaucoma and may be applicable to other gene therapies for intraocular diseases.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Ophthalmology

Neuroprotection in Glaucoma: Towards Clinical Trials and Precision Medicine

Tasneem Z. Khatib et al.

CURRENT EYE RESEARCH (2020)

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Article Chemistry, Multidisciplinary

Therapeutic Contact Lens for Scavenging Excessive Reactive Oxygen Species on the Ocular Surface

Seung Woo Choi et al.

ACS NANO (2020)

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Article Ophthalmology

Can postoperative dexamethasone nanoparticle eye drops replace mitomycin C in trabeculectomy?

Gauti Johannesson et al.

ACTA OPHTHALMOLOGICA (2020)

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Article Chemistry, Applied

Functional chitosan oligosaccharide nanomicelles for topical ocular drug delivery of dexamethasone

Xiaoyue Xu et al.

CARBOHYDRATE POLYMERS (2020)

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Article Pharmacology & Pharmacy

Co-delivery of brinzolamide and miRNA-124 by biodegradable nanoparticles as a strategy for glaucoma therapy

Tingting Li et al.

DRUG DELIVERY (2020)

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Article Chemistry, Medicinal

Preparation of levofloxacin loaded in situ gel for sustained ocular delivery: in vitro and ex vivo evaluations

Pooja Jain et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2020)

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Article Pharmacology & Pharmacy

24-Month Phase I/II Clinical Trial of Bimatoprost Sustained-Release Implant (Bimatoprost SR) in Glaucoma Patients

E. Randy Craven et al.

DRUGS (2020)

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Article Chemistry, Multidisciplinary

Benzoic acid derivative-modified chitosan-g-poly(N-isopropylacrylamide): Methoxylation effects and pharmacological treatments of Glaucoma-related neurodegeneration

Li-Jyuan Luo et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Pharmacology & Pharmacy

Chitosan-N-acetylcysteine modified HP-β-CD inclusion complex as a potential ocular delivery system for anti-cataract drug: Quercetin

Qi Lan et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

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Article Pharmacology & Pharmacy

Novel Sustained-Release Drug Delivery System for Dry Eye Therapy by Rebamipide Nanoparticles

Noriaki Nagai et al.

PHARMACEUTICS (2020)

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Article Engineering, Biomedical

Programmable prodrug micelle with size-shrinkage and charge-reversal for chemotherapy-improved IDO immunotherapy

Liangliang Dai et al.

BIOMATERIALS (2020)

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Article Chemistry, Medicinal

Latanoprost niosomes as a sustained release ocular delivery system for the management of glaucoma

Dina Fathalla et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2020)

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Article Geriatrics & Gerontology

Bimatoprost Implant: First Approval

Matt Shirley

DRUGS & AGING (2020)

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Article Pharmacology & Pharmacy

Neuroprotection: A versatile approach to combat glaucoma

Santoshi Naik et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Ophthalmology

Management of moderate-to-severe dry eye disease using chitosan-N-acetylcysteine (Lacrimera®) eye drops: a retrospective case series

Johannes Nepp et al.

INTERNATIONAL OPHTHALMOLOGY (2020)

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Review Nanoscience & Nanotechnology

A Review on Surface-Functionalized Cellulosic Nanostructures as Biocompatible Antibacterial Materials

Mandana Tavakolian et al.

NANO-MICRO LETTERS (2020)

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Review Biotechnology & Applied Microbiology

Hydrogel Biomaterials for Application in Ocular Drug Delivery

Courtney R. Lynch et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Development and Characterization of a Novel Peptide-Loaded Antimicrobial Ocular Insert

Eleonora Terreni et al.

BIOMOLECULES (2020)

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Article Biochemistry & Molecular Biology

Polypeptide and glycosaminoglycan polysaccharide as stabilizing polymers in nanocrystals for a safe ocular hypotensive effect

Marwa Donia et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Nanoscience & Nanotechnology

Potential Therapeutic Usage of Nanomedicine for Glaucoma Treatment

Song Kwon et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Pharmacology & Pharmacy

Nanoemulsion as a feasible and biocompatible carrier for ocular delivery of travoprost: Improved pharmacokinetic/pharmacodynamic properties

Ayman Ismail et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Chemistry, Multidisciplinary

Design of ocular drug delivery platforms and in vitro - in vivo evaluation of riboflavin to the cornea by non-interventional (epi-on) technique for keratoconus treatment

Eren Aytekin et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Pharmacology & Pharmacy

Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

Duhyeong Hwang et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Materials Science, Biomaterials

Multiple drug delivery from the drug-implants-laden silicone contact lens: Addressing the issue of burst drug release

Ankita R. Desai et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Ophthalmology

Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1)

Felipe A. Medeiros et al.

OPHTHALMOLOGY (2020)

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Review Polymer Science

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

Alexandra Zamboulis et al.

POLYMERS (2020)

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Review Polymer Science

Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review

Vivek Puri et al.

POLYMERS (2020)

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Review Biochemistry & Molecular Biology

Quaternary Ammonium Chitosans: The Importance of the Positive Fixed Charge of the Drug Delivery Systems

Angela Fabiano et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Materials Science, Biomaterials

Long-acting mucoadhesive thermogels for improving topical treatments of dry eye disease

Li-Jyuan Luo et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Medicine, Research & Experimental

Crown Ether Nanovesicles (Crownsomes) Repositioned Phenytoin for Healing of Corneal Ulcers

Dina B. Mahmoud et al.

MOLECULAR PHARMACEUTICS (2020)

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Article Engineering, Biomedical

Drug-loaded chitosan film prepared via facile solution casting and air-drying of plain water-based chitosan solution for ocular drug delivery

Boxuan Li et al.

BIOACTIVE MATERIALS (2020)

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Article Nanoscience & Nanotechnology

PLGA Nanoparticle Platform for Trans-Ocular Barrier to Enhance Drug Delivery: A Comparative Study Based on the Application of Oligosaccharides in the Outer Membrane of Carriers

Ge Jiang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Polymer Science

Reduction-responsive disulfide linkage core-cross-linked polymeric micelles for site-specific drug delivery

Gaizhen Kuang et al.

POLYMER CHEMISTRY (2020)

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Article Materials Science, Biomaterials

Brimonidine-LAPONITE® intravitreal formulation has an ocular hypotensive and neuroprotective effect throughout 6 months of follow-up in a glaucoma animal model

M. J. Rodrigo et al.

BIOMATERIALS SCIENCE (2020)

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Article Multidisciplinary Sciences

Besifloxacin liposomes with positively charged additives for an improved topical ocular delivery

Giselly Almeida dos Santos et al.

SCIENTIFIC REPORTS (2020)

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Article Materials Science, Biomaterials

Brimonidine-montmorillonite hybrid formulation for topical drug delivery to the eye

Chun Gwon Park et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Engineering, Biomedical

Emerging role of nanosuspensions in drug delivery systems

Shery Jacob et al.

BIOMATERIALS RESEARCH (2020)

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Article Pharmacology & Pharmacy

Incorporation of ion exchange functionalized-montmorillonite into solid lipid nanoparticles with low irritation enhances drug bioavailability for glaucoma treatment

Shuo Liu et al.

DRUG DELIVERY (2020)

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Review Chemistry, Multidisciplinary

A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems

Yongtao Duan et al.

RSC ADVANCES (2020)

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Article Pharmacology & Pharmacy

Formulation and investigation of pilocarpine hydrochloride niosomal gels for the treatment of glaucoma: intraocular pressure measurement in white albino rabbits

Neelam Jain et al.

DRUG DELIVERY (2020)

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Article Ophthalmology

Novel hydrogel-based ocular drug delivery system for the treatment of conjunctivitis

S. Deepthi et al.

INTERNATIONAL OPHTHALMOLOGY (2019)

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Article Ophthalmology

Thermosensitive chitosan-gelatin-based hydrogel containing curcumin-loaded nanoparticles and latanoprost as a dual-drug delivery system for glaucoma treatment

Yung-Hsin Cheng et al.

EXPERIMENTAL EYE RESEARCH (2019)

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Article Pharmacology & Pharmacy

Gelatinized core liposomes: A new Trojan horse for the development of a novel timolol maleate glaucoma medication

Rania M. Hathout et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Ophthalmology

Effect of 2 Novel Sustained-release Drug Release Systems on Bleb Fibrosis: An In Vivo Trabeculectomy Study in a Rabbit Model

Forrest B. Swann et al.

JOURNAL OF GLAUCOMA (2019)

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Review Multidisciplinary Sciences

Supramolecular nanoscale drug-delivery system with ordered structure

Xin Jin et al.

NATIONAL SCIENCE REVIEW (2019)

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Article Pharmacology & Pharmacy

Development, Optimization, and In Vitro/In Vivo Characterization of Enhanced Lipid Nanoparticles for Ocular Delivery of Ofloxacin: the Influence of Pegylation and Chitosan Coating

Hussein M. Eid et al.

AAPS PHARMSCITECH (2019)

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Article Engineering, Biomedical

Injectable cell-encapsulating composite alginate-collagen platform with inducible termination switch for safer ocular drug delivery

Francisca Siu Yin Wong et al.

BIOMATERIALS (2019)

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Article Nanoscience & Nanotechnology

Natamycin solid lipid nanoparticles - sustained ocular delivery system of higher corneal penetration against deep fungal keratitis: preparation and optimization

Ahmed Khames et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Review Biochemistry & Molecular Biology

Stimulus-Responsive Hydrogel for Ophthalmic Drug Delivery

Deqing Lin et al.

MACROMOLECULAR BIOSCIENCE (2019)

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Article Materials Science, Biomaterials

Amination degree of gelatin is critical for establishing structure-property-function relationships of biodegradable thermogels as intracameral drug delivery systems

Li-Jyuan Luo et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Materials Science, Biomaterials

Bimatoprost loaded nanovesicular long-acting sub-conjunctival in-situ gelling implant: In vitro and in vivo evaluation

Monika Yadav et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Materials Science, Multidisciplinary

Effect of Ultra-Small Chitosan Nanoparticles Doped with Brimonidine on the Ultra-Structure of the Trabecular Meshwork of Glaucoma Patients

Indu Barwal et al.

MICROSCOPY AND MICROANALYSIS (2019)

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Article Ophthalmology

A Phase 3, Randomized, Double-Masked Study of OTX-101 Ophthalmic Solution 0.09% in the Treatment of Dry Eye Disease

Damien F. Goldberg et al.

OPHTHALMOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Liposomes for effective drug delivery to the ocular posterior chamber

Sisi Lai et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Article Nanoscience & Nanotechnology

Silver nanoparticles induce reactive oxygen species-mediated cell cycle delay and synergistic cytotoxicity with 3-bromopyruvate in Candida albicans, but not in Saccharomyces cerevisiae

Bokyoung Lee et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Chemistry, Multidisciplinary

Co-delivery of latanoprost and timolol from micelles-laden contact lenses for the treatment of glaucoma

Jiawen Xu et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Ophthalmology

Hyperlipidemia induces meibomian gland dysfunction

Jinghua Bu et al.

OCULAR SURFACE (2019)

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Review Chemistry, Multidisciplinary

Safety Assessment of Nanomaterials to Eyes: An Important but Neglected Issue

Shuang Zhu et al.

ADVANCED SCIENCE (2019)

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Review Chemistry, Medicinal

Medicinal prospects of antioxidants: A review

Kumari Neha et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

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Review Chemistry, Multidisciplinary

Nanoscale systems for local drug delivery

Tianjiao Ji et al.

NANO TODAY (2019)

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Article Ophthalmology

Δ9-Tetrahydrocannabinol Derivative-Loaded Nanoformulation Lowers Intraocular Pressure in Normotensive Rabbits

Pranjal S. Taskar et al.

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Leucaena leucocephala (Lam.) galactomannan nanoparticles: Optimization and characterization for ocular delivery in glaucoma treatment

Neeraj Mittal et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Pharmacology & Pharmacy

Chitosan/hydroxyethyl cellulose inserts for sustained-release of dorzolamide for glaucoma treatment: In vitro and in vivo evaluation

Jucara R. Franca et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Chemistry, Multidisciplinary

Synergistic Chemotherapy and Photodynamic Therapy of Endophthalmitis Mediated by Zeolitic Imidazolate Framework-Based Drug Delivery Systems

Hao Chen et al.

SMALL (2019)

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Article Engineering, Biomedical

Dendritic Effects of Injectable Biodegradable Thermogels on Pharmacotherapy of Inflammatory Glaucoma-Associated Degradation of Extracellular Matrix

Duc Dung Nguyen et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Nanoscience & Nanotechnology

Novel redispersible nanosuspensions stabilized by co-processed nanocrystalline cellulose-sodium carboxymethyl starch for enhancing dissolution and oral bioavailability of baicalin

Jin Xie et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Chemistry, Multidisciplinary

Simultaneous co-delivery of neuroprotective drugs from multi-loaded PLGA microspheres for the treatment of glaucoma

A. Arranz-Romera et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Ophthalmology

Intracameral Sustained-Release Bimatoprost Implant Delivers Bimatoprost to Target Tissues with Reduced Drug Exposure to Off-Target Tissues

Jennifer R. Seal et al.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2019)

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Article Ophthalmology

Co-Delivery of Timolol and Brimonidine with a Polymer Thin-Film Intraocular Device

Karen E. Samy et al.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2019)

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Article Pharmacology & Pharmacy

Amphotericin B containing microneedle ocular patch for effective treatment of fungal keratitis

Girdhari Roy et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Nanoscience & Nanotechnology

Topical nanodelivery system of lutein for the prevention of selenite-induced cataract

Ede Bodoki et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Article Ophthalmology

Effect of Rapamycin Microspheres in Sjogren Syndrome Dry Eye: Preparation and Outcomes

Shasha Wang et al.

OCULAR IMMUNOLOGY AND INFLAMMATION (2019)

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Article Ophthalmology

A Randomized, Controlled Trial of Cyclosporine A Cationic Emulsion in Pediatric Vernal Keratoconjunctivitis

Andrea Leonardi et al.

OPHTHALMOLOGY (2019)

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Article Pharmacology & Pharmacy

Brinzolamide-loaded nanoemulsions: ex vivo transcorneal permeation, cell viability and ocular irritation tests

Mohammad Mehdi Mahboobian et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2019)

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Article Nanoscience & Nanotechnology

Self-Assembled Multilayer Films for Time-Controlled Ocular Drug Delivery

Monica Machado et al.

ACS APPLIED BIO MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Drug-eluting contact lens containing cyclosporine-loaded cholesterol-hyaluronate micelles for dry eye syndrome

Jonghwan Mun et al.

RSC ADVANCES (2019)

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Article Pharmacology & Pharmacy

Proniosomal gel-derived niosomes: an approach to sustain and improve the ocular delivery of brimonidine tartrate; formulation, in-vitro characterization, and in-vivo pharmacodynamic study

Alaa Emad Eldeeb et al.

DRUG DELIVERY (2019)

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Article Chemistry, Multidisciplinary

Memantine-Loaded PEGylated Biodegradable Nanoparticles for the Treatment of Glaucoma

Elena Sanchez-Lopez et al.

SMALL (2018)

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Article Instruments & Instrumentation

Ex vivo rabbit cornea diffusion studies with a soluble insert of moxifloxacin

Maria Sebastian-Morello et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2018)

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Article Ophthalmology

Targeted therapy for the post-operative conjunctiva: SPARC silencing reduces collagen deposition

Li Fong Seet et al.

BRITISH JOURNAL OF OPHTHALMOLOGY (2018)

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Article Chemistry, Applied

Effect of deacetylation degree on controlled pilocarpine release from injectable chitosan-g-poly(N-isopropylacrylamide) carriers

Li-Jyuan Luo et al.

CARBOHYDRATE POLYMERS (2018)

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Article Pharmacology & Pharmacy

Sustained ocular delivery of Dorzolamide-HCl via proniosomal gel formulation: in-vitro characterization, statistical optimization, and in-vivo pharmacodynamic evaluation in rabbits

Nagwa Hussein Fouda et al.

DRUG DELIVERY (2018)

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Article Pharmacology & Pharmacy

Fabrication of a drug delivery system that enhances antifungal drug corneal penetration

Jingguo Li et al.

DRUG DELIVERY (2018)

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Article Pharmacology & Pharmacy

Improving the topical ocular pharmacokinetics of lyophilized cyclosporine A-loaded micelles: formulation, in vitro and in vivo studies

Yinglan Yu et al.

DRUG DELIVERY (2018)

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Article Chemistry, Medicinal

Dorzolamide nanoliposome as a long action ophthalmic delivery system in open angle glaucoma and ocular hypertension patients

Maryann Kouchak et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2018)

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Article Biochemistry & Molecular Biology

Sustained release timolol maleate loaded ocusert based on biopolymer composite

Revathy V. Nair et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Biochemistry & Molecular Biology

Nanogel-based natural polymers as smart carriers for the controlled delivery of Timolol Maleate through the cornea for glaucoma

Roya Ilka et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Nanoscience & Nanotechnology

Controlled drug delivery for glaucoma therapy using montmorillonite/Eudragit microspheres as an ion-exchange carrier

Shuangyan Tian et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Nanoscience & Nanotechnology

Montmorillonite/chitosan nanoparticles as a novel controlled-release topical ophthalmic delivery system for the treatment of glaucoma

Juan Li et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Pharmacology & Pharmacy

Treatment merits of Latanoprost/Thymoquinone - Encapsulated liposome for glaucomatus rabbits

Heba Mohamed Fahmy et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Chemistry, Multidisciplinary

Long-term intraocular pressure reduction with intracameral polycaprolactone glaucoma devices that deliver a novel anti-glaucoma agent

Jean Kim et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Chemistry, Applied

Nanostructured lipid carriers for intraocular brimonidine localisation: development, in-vitro and in-vivo evaluation

Noha S. El-Salamouni et al.

JOURNAL OF MICROENCAPSULATION (2018)

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Article Medicine, Research & Experimental

DenTimol as A Dendrimeric Timolol Analogue for Glaucoma Therapy: Synthesis and Preliminary Efficacy and Safety Assessment

Michael G. Lancina et al.

MOLECULAR PHARMACEUTICS (2018)

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Article Multidisciplinary Sciences

Enhancement of pharmacokinetic and pharmacological behavior of ocular dorzolamide after factorial optimization of self-assembled nanostructures

Enas A. M. R. Afify et al.

PLOS ONE (2018)

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Article Materials Science, Biomaterials

Co-delivery of timolol and hyaluronic acid from semi-circular ring-implanted contact lenses for the treatment of glaucoma: in vitro and in vivo evaluation

Ankita R. Desai et al.

BIOMATERIALS SCIENCE (2018)

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Article Instruments & Instrumentation

A stimulus-responsive, in situ-forming, nanoparticle-laden hydrogel for ocular drug delivery

Maryam Kabiri et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2018)

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Review Pharmacology & Pharmacy

Ocular Drug Delivery Barriers-Role of Nanocarriers in the Treatment of Anterior Segment Ocular Diseases

Rinda Devi Bachu et al.

PHARMACEUTICS (2018)

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Review Biochemistry & Molecular Biology

Ocular Drug Delivery: Role of Degradable Polymeric Nanocarriers for Ophthalmic Application

Cheng-Han Tsai et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Chemistry, Medicinal

Chitosan-Gelatin Hydrogel Crosslinked With Oxidized Sucrose for the Ocular Delivery of Timolol Maleate

Gina S. El-Feky et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

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Article Medicine, Research & Experimental

Thermo-sensitive gel in glaucoma therapy for enhanced bioavailability: In vitro characterization, in vivo pharmacokinetics and pharmacodynamics study

Youmei Zeng et al.

LIFE SCIENCES (2018)

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Article Pharmacology & Pharmacy

TPGS modified nanoliposomes as an effective ocular delivery system to treat glaucoma

Quansheng Jin et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Engineering, Biomedical

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