☆ 4.7 Review

Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review

POLYMERS (2023)

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Article Polymer Science

Green Nanoarchitectonics of Silver Nanoparticles for Antimicrobial Activity Against Resistant Pathogens

Gabriela Pereira Chuy et al.

Summary: Biosynthesized silver nanoparticles from Klebsiella pneumoniae show potent antimicrobial activity against drug-resistant pathogens and low cytotoxicity in cells, indicating potential medical applicability as promising antimicrobial agents.

JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS (2022)

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Article Medicine, General & Internal

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Christopher J. L. Murray et al.

Summary: Antimicrobial resistance (AMR) poses a significant threat to global human health, and this study provides the most comprehensive estimates of AMR burden to date. By estimating deaths and disability-adjusted life-years (DALYs) associated with bacterial AMR in 204 countries and territories in 2019, the study highlights the impact of resistance and the leading pathogen-drug combinations contributing to it.

LANCET (2022)

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Review Microbiology

Antibiotic resistance in the environment

D. G. Joakim Larsson et al.

Summary: Antibiotic resistance is a global health challenge, with factors driving evolution and transmission being important to quantify and identify. The environment plays a crucial role, and understanding and managing the resistance crisis can be achieved through implementing monitoring and assessment methods to reduce risks.

NATURE REVIEWS MICROBIOLOGY (2022)

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Article Microbiology

Antibacterial Activity and Multi-Targeting Mechanism of Dehydrocorydaline From Corydalis turtschaninovii Bess. Against Listeria monocytogenes

Gowoon Kim et al.

Summary: This study identified and characterized a novel antibacterial agent, dehydrocorydaline, in the Corydalis turschaninovii rhizome. Dehydrocorydaline demonstrated strong antibacterial activity against L. monocytogenes, as well as inhibitory effects on biofilm formation and bacterial motility. Label-free quantitative proteomics revealed that dehydrocorydaline has multiple targets for combating L. monocytogenes, including dysregulation of carbohydrate metabolism, suppression of cell wall synthesis, and inhibition of bacterial motility.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Phyto-Mediated Copper Oxide Nanoparticles for Antibacterial, Antioxidant and Photocatalytic Performances

Kenneth Ssekatawa et al.

Summary: The greatest challenge for current and future generations is antimicrobial resistance. This study examined the effectiveness of copper oxide nanoparticles synthesized from Camellia sinensis extract and Prunus africana bark extract against carbapenem-resistant bacteria. These nanoparticles showed potential as antimicrobial agents and also exhibited photocatalytic and antioxidant activities.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Microbiology

Current Knowledge on the Oxidative-Stress-Mediated Antimicrobial Properties of Metal-Based Nanoparticles

Nour Mammari et al.

Summary: The emergence of multidrug-resistant bacteria is a major public health issue. Nanotechnologies, particularly metal-based nanoparticles (NPs), offer potential solutions for the development of effective antimicrobial agents. Inducing oxidative stress through NPs represents a valuable and powerful strategy to combat multidrug-resistant bacteria.

MICROORGANISMS (2022)

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Article Chemistry, Multidisciplinary

Fabrication of Biohybrid Nanofibers by the Green Electrospinning Technique and Their Antibacterial Activity

Badr M. Thamer et al.

Summary: Biohybrid nanofiber sheets based on eco-friendly components were fabricated by incorporating myrrh extract into poly(vinyl alcohol)/tragacanth gum nanofiber mats. The prepared nanofibers showed uniform morphology and exhibited significant antibacterial activity.

ACS OMEGA (2022)

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Article Multidisciplinary Sciences

An innovative green synthesis approach of chitosan nanoparticles and their inhibitory activity against phytopathogenic Botrytis cinerea on strawberry leaves

Noura El-Ahmady El-Naggar et al.

Summary: Green synthesis is a newly emerging field in nanobiotechnology that utilizes eco-friendly materials to implement sustainable processes. In this study, a biological-based strategy using Pelargonium graveolens leaves extract was proposed for the synthesis of chitosan nanoparticles (CNPs). The optimal conditions for biosynthesis were determined, and the synthesized CNPs exhibited efficient antifungal activity against Botrytis cinerea. The study also highlighted the importance of optimizing CNPs concentrations to reduce potential harmful side effects.

SCIENTIFIC REPORTS (2022)

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Review Polymer Science

Chitosan as a Tool for Sustainable Development: A Mini Review

Soundouss Maliki et al.

Summary: New developments require innovative ecofriendly materials with biocompatibility, biodegradability, and versatility. Chitosan, the second most abundant material in the world, has unique properties that can be used for various purposes, promoting the design and development of sustainable materials. For example, it can be used as an alternative for food packaging or in sustainable agriculture. Chitosan can also reduce pollution in other industrial processes. This review highlights important advances in the sustainable use of chitosan for promoting circular economy.

POLYMERS (2022)

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Review Chemistry, Medicinal

Nanomaterials: The New Antimicrobial Magic Bullet

John Ndayishimiye et al.

Summary: Bacterial infections continue to be a major cause of mortality and morbidity worldwide, despite the use of existing antibiotics and efforts to discover new ones. The emergence of antibiotic-resistant strains highlights the need for new bactericidal therapies. Nanomaterial-based strategies offer promise due to their ability to circumvent resistance mechanisms. This review discusses novel nanomaterial-based formulations targeting bacterial infections and resistance, along with their types and activities as delivery systems or antimicrobials, and issues of toxicity.

ACS INFECTIOUS DISEASES (2022)

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Article Chemistry, Multidisciplinary

Fabrication of Curcumin@Ag Loaded Core/Shell Nanofiber Membrane and its Synergistic Antibacterial Properties

Qiuxiang Wang et al.

Summary: In this study, a core/shell structure nanofiber membrane loaded with curcumin and silver nanoparticles was prepared using coaxial electrospinning technology. The results showed that the membrane exhibited excellent antibacterial properties against both Staphylococcus aureus and Escherichia coli.

FRONTIERS IN CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems

Chongshan Dai et al.

Summary: Curcumin, an important component of turmeric, is considered a safe oral treatment for bacterial infections and has exhibited antibacterial activities against both Gram-negative and Gram-positive bacteria. Its antibacterial actions include disrupting bacterial membranes, inhibiting the production of bacterial virulence factors and biofilm formation, as well as inducing oxidative stress. Additionally, curcumin acts as a broad-spectrum antibacterial adjuvant, showing marked additive or synergistic effects with conventional antibiotics or non-antibiotic compounds.

ANTIOXIDANTS (2022)

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Article Multidisciplinary Sciences

Fabrication, characterization and in vitro evaluation of Melia dubia extract infused nanofibers for wound dressing

Sathish Kumar Karuppannan et al.

Summary: This study focuses on the fabrication and characterization of Melia dubia leaf extract incorporated polycaprolactone/gelatin electrospun nanofibers for wound dressing applications. The nanofibers exhibited smooth and ultra-fine morphology with enhanced mechanical properties after the incorporation of the leaf extract. The fabricated nanofibers showed antioxidant activity, sustained drug release, and effective antibacterial activity against various pathogens. The results also demonstrated the biocompatibility of the nanofibers with fibroblast cells, indicating their potential for wound healing.

JOURNAL OF KING SAUD UNIVERSITY SCIENCE (2022)

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Article Multidisciplinary Sciences

Green synthesis of chitosan nanoparticles, optimization, characterization and antibacterial efficacy against multi drug resistant biofilm-forming Acinetobacterbaumannii

Noura El-Ahmady El-Naggar et al.

Summary: Chitosan nanoparticles (CNPs) are versatile cationic polymeric nanoparticles with high biocompatibility and environmental safety, making them promising for various applications in agriculture, medical, and pharmaceutical fields. In this study, CNPs were successfully biosynthesized using aqueous extract of Eucalyptus globulus Labill fresh leaves, and the optimal conditions for CNPs production were determined. The biosynthesized CNPs showed small and uniform particle size, and exhibited antibacterial activity against multidrug-resistant bacteria. These findings demonstrate the potential of biosynthesized CNPs for diverse medical and pharmaceutical applications.

SCIENTIFIC REPORTS (2022)

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Review Chemistry, Analytical

Recent Advances in Nanotechnology for the Management of Klebsiella pneumoniae-Related Infections

Mahmood Barani et al.

Summary: This review summarizes the research progress of using nanotechnology against Klebsiella pneumoniae. The emergence of multidrug-resistant strains has made the treatment of K. pneumoniae infections challenging. Therefore, exploring new management strategies is urgently needed.

BIOSENSORS-BASEL (2022)

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Review Microbiology

Antibacterial activity of recently approved antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) strains: A systematic review and meta-analysis

Fei Liu et al.

Summary: This meta-analysis examined the in vitro activity of recently approved antibiotics against MRSA isolates. The results showed that telavancin, dalbavancin, oritavancin, and tedizolid had potent antibacterial activity against MRSA isolates, suggesting their potential as useful antibiotics for treating MRSA infections.

ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS (2022)

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Review Environmental Sciences

Electrospun composite nanofibers as novel high-performance and visible-light photocatalysts for removal of environmental pollutants: A review

Shadi Asgari et al.

Summary: Environmental pollution caused by industries and human activities is a serious global challenge, while the world is also facing an energy crisis due to population growth. Designing solar-driven photocatalysts inspired by plant photosynthesis offers a fantastic solution to use solar energy for environmental pollutant removal. The use of polymeric and non-polymeric-based electrospun composite nanofibers as innovative photocatalysts not only increases photocatalytic activity, but also overcomes the limitations of traditional nanosized powder photocatalysts. These composite nanofibers have shown long-term stability, high photocatalytic efficiency, and suitability for various applications such as water treatment and antibacterial usage.

ENVIRONMENTAL RESEARCH (2022)

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Review Chemistry, Multidisciplinary

Polymers showing intrinsic antimicrobial activity

Meltem Haktaniyan et al.

Summary: Pathogenic microorganisms are a major threat to human health and the increasing levels of antimicrobial resistance require new approaches, such as antimicrobial polymers. These polymers, derived from natural sources or synthesized with enhancing elements, have shown intrinsic antimicrobial properties and can be used as surface coatings or antibacterial agents in various applications.

CHEMICAL SOCIETY REVIEWS (2022)

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Review Chemistry, Multidisciplinary

Green synthesis of nanoparticles using plant extracts: a review

Sapana Jadoun et al.

Summary: Green synthesis of nanoparticles has potential applications in reducing the usage of toxic chemicals, with the use of plants as materials usually being safe and containing reducing and capping agents.

ENVIRONMENTAL CHEMISTRY LETTERS (2021)

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Article

Efficacy of phytochemicals as immunomodulators in managing COVID-19: a comprehensive view

Sonali Bhattacharya et al.

VirusDisease (2021)

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Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Nutrition & Dietetics

Polyphenols and Human Health: The Role of Bioavailability

Chiara Di Lorenzo et al.

Summary: Polyphenols are a group of phytochemicals with potential health-promoting effects, classified as flavonoid and non-flavonoid molecules. Their positive effects on health are influenced by factors affecting their bioavailability, and recent studies have shown that their metabolites may have beneficial properties.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences

The antimicrobial capacity of Cistus salviifolius and Punica granatum plant extracts against clinical pathogens is related to their polyphenolic composition

Francisco Javier Alvarez-Martinez et al.

Summary: The study found that extracts from Cistus salviifolius and Punica granatum have different antibacterial activity against Staphylococcus aureus, and this activity is linked to the resistance profile of the bacteria to specific antibiotics, which could aid in the development of combination therapies including botanical extracts.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Compositions and antimicrobial properties of binary ZnO-CuO nanocomposites encapsulated calcium and carbon from Calotropis gigantea targeted for skin pathogens

G. Ambarasan Govindasamy et al.

Summary: The study demonstrates that Calotropis gigantea extract combined with ecofriendly nanotechnology can provide promising antimicrobial activity against various skin pathogens, particularly showing strong efficacy against MDR pathogens. The binary ZnO-CuO nanocomposites from C. gigantea exhibit significant bactericidal effects and have potential applications in antimicrobial therapies. Further molecular studies are required to fully understand the biocidal mechanism of the nanocomposites.

SCIENTIFIC REPORTS (2021)

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Article Biotechnology & Applied Microbiology

Isolation, biosynthesis and antimicrobial activity of gold nanoparticles produced with extracts of Anabaena spiroides

Chinmayee Priyadarshini Mandhata et al.

Summary: Green-synthesized gold nanoparticles using cyanobacteria show promise as potential antibacterials against multidrug-resistant bacteria, with reliable in vitro results.

BIOPROCESS AND BIOSYSTEMS ENGINEERING (2021)

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Article Chemistry, Applied

Boosting the antibacterial activity of chitosan-gold nanoparticles against antibiotic-resistant bacteria by Punicagranatum L. extract

Mohamed A. Mohamady Hussein et al.

Summary: A new series of chitosan-gold hybrid nanoparticles were synthesized for delivering pomegranate peel extract, with pomegranate peel acting as a reducing agent leading to a significant reduction in particle size. The developed nanoparticles exhibited higher stability at different pH values and released most of the loaded extract over a 24-hour period. The antibacterial activity of the nanoparticles showed a synergistic effect against methicillin-resistant S. aureus.

CARBOHYDRATE POLYMERS (2021)

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Review Biochemistry & Molecular Biology

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

Mostafa Mabrouk et al.

Summary: Designing of nanomaterials for biomedical applications is a research priority, with factors like size, shape, surface charge, and microstructures influencing nanoparticle performance and being dependent on synthesis methods. The characterization techniques for nanomaterials vary in concepts and results, and this review discusses recent trends and key applications in biomedical engineering.

MOLECULES (2021)

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Article Multidisciplinary Sciences

Padina boryana mediated green synthesis of crystalline palladium nanoparticles as potential nanodrug against multidrug resistant bacteria and cancer cells

Hana Sonbol et al.

Summary: Green synthesized palladium nanoparticles (Pd-NPs) offer valuable clinical treatment possibilities with strong antibacterial/antibiofilm activities against multi-drug resistant pathogens and breast cancer cells. The study demonstrates the potential role of brown alga-mediated Pd-NPs in successful clinical management of drug-resistant pathogens and breast cancer.

SCIENTIFIC REPORTS (2021)

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Review Polymer Science

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

Vera Alexandra Spirescu et al.

Summary: Infectious diseases remain a major health threat due to limitations of antimicrobial drugs and microbial resistance. Research has shifted towards finding novel antimicrobial agents, with nanotechnology and polymeric nanoparticles showing potential advantages.

POLYMERS (2021)

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Article Chemistry, Multidisciplinary

Aloe Vera-Mediated Te Nanostructures: Highly Potent Antibacterial Agents and Moderated Anticancer Effects

David Medina-Cruz et al.

Summary: Nanomedicine offers promising solutions to healthcare concerns like cancer and antibiotic resistance, with green nanotechnology presenting a solution to traditional drawbacks in nanomaterial synthesis. This study developed a method for synthesizing tellurium (Te) nanostructures using aloe vera extracts as reducing and capping agents, resulting in AV-TeNPs with potential biomedical applications in antibacterial and anticancer fields.

NANOMATERIALS (2021)

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Review Pharmacology & Pharmacy

Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties

Umile Gianfranco Spizzirri et al.

Summary: Recent research has focused on the development of innovative polymeric nanocarriers using nanotechnologies for site-specific release of active molecules with antimicrobial activity. High performing nanocarriers have been synthesized using a wide range of starting polymer structures, showing great chemical versatility. Over the last decade, significant interest has been garnered in investigating antimicrobial substances originating from plants, herbs, and agro-food waste by-products.

PHARMACEUTICS (2021)

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Review Microbiology

Metallic Nanoparticles-Friends or Foes in the Battle against Antibiotic-Resistant Bacteria?

Francisco Amaro et al.

Summary: Metallic nanoparticles are promising tools for infection control due to their unique properties, but bacteria can still develop stable resistance mechanisms against them. Careful management is necessary to preserve the efficacy of these antimicrobials.

MICROORGANISMS (2021)

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Article Chemistry, Multidisciplinary

Electrospun Polyvinyl Alcohol Loaded with Phytotherapeutic Agents for Wound Healing Applications

Diana Serbezeanu et al.

Summary: This study developed poly (vinyl alcohol)-based nanofiber mats loaded with phytotherapeutic agents using electrospinning technique. The addition of Thymus vulgaris, Salvia officinalis folium, and Hyperici herba extracts changed the morphology and reduced the diameter of the fibers. Samples with Hyperici herba and Thymus vulgaris exhibited the highest phenol contents.

NANOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Marta Kolodziejska et al.

Summary: Chitosan, with its unique chemical, biological, and physical properties, is extensively used in tissue engineering as a main component in biomaterials. It can be modified and blended to meet specific requirements, making it versatile for various applications such as membranes, scaffolds, drug carriers, and hydrogels.

NANOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Nanomaterials in the Management of Gram-Negative Bacterial Infections

Mahmood Barani et al.

Summary: Exploring bacterial virulence factors in early infection therapy of Escherichia coli is a major challenge, but intelligent devices based on nanotechnology have the potential for rapid detection of E. coli at the point of care.

NANOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

On-Demand Drug Delivery Systems Using Nanofibers

Baljinder Singh et al.

Summary: Nanofibers are widely used in on-demand drug delivery systems for customized drug release, with their distinguishing features and properties allowing for effective drug-loading capabilities and controllable release. Different types of nanofibers are classified based on their drug-release mechanisms, structure, and content, with additional consideration for the impact of polymer choice and environmental conditions on release characteristics.

NANOMATERIALS (2021)

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Review Biochemistry & Molecular Biology

Prospects of Polymeric Nanofibers Loaded with Essential Oils for Biomedical and Food-Packaging Applications

Anjum Hamid Rather et al.

Summary: Essential oils embedded in polymeric nanofibers fabricated by electrospinning show antimicrobial, anti-inflammatory, and antioxidant properties, reducing the need for synthetic drugs in various industries. These nanofibers enhance barrier properties against light, oxygen, and heat in food packaging, while also increasing shelf-life of food products. The controlled release of naturally derived chemical compounds in these nanofibers prevents degradation and makes them effective as active packaging materials.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Pharmacology & Pharmacy

L-Menthol-Loadable Electrospun Fibers of PMVEMA Anhydride for Topical Administration

Amalia Mira et al.

Summary: Electrospun fibers from PMVEMA and menthol solutions were characterized, showing higher encapsulation efficiency and stability of menthol in P139 fibers compared to P119 fibers. The morphology and size of the fibers were analyzed, and in vitro biological assays demonstrated no cytotoxicity induction.

PHARMACEUTICS (2021)

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Review Chemistry, Multidisciplinary

Electrospinning for drug delivery applications: A review

Andrea Luraghi et al.

Summary: Drug delivery devices are promising in maximizing therapeutic effects and minimizing undesired side effects. Electrospun nanofibers have unique features like biocompatibility and flexibility, making them efficient in delivering active principles for a wide range of drugs. The technique of electrospinning allows for easy tuning and endless combinations, potentially leading to personalized medicine.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Microbiology

Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives

Natalia Vaou et al.

Summary: The increasing incidence of drug-resistant pathogens has led to a need for identifying new bioactive compounds from medicinal plants. Plant-derived compounds offer potential in combating pathogenic bacteria, but faces challenges in extraction, testing, and characterization. Research on mechanisms of action, pharmacokinetics, and pharmacodynamics of medicinal plant extracts is crucial for developing novel antimicrobial agents.

MICROORGANISMS (2021)

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Article Anatomy & Morphology

Green synthesized AgNPs from Periploca hydaspidis Falc. and its biological activities

Saima Ali et al.

Summary: Characterization of bio-synthesized silver nanoparticles using Periploca hydaspidis plant extract revealed their potential as antioxidant, antimicrobial, antifungal and anticancer agents.

MICROSCOPY RESEARCH AND TECHNIQUE (2021)

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Article Biochemistry & Molecular Biology

Biosynthesis of Zinc Oxide Nanoparticles from Acacia nilotica (L.) Extract to Overcome Carbapenem-Resistant Klebsiella Pneumoniae

Elsayim Rasha et al.

Summary: This study investigated the antibacterial activity of biosynthesized zinc oxide nanoparticles (ZnO-NPs) against carbapenem-resistant Klebsiella pneumoniae (KPC) in vitro and in vivo. The results showed that ZnO-NPs had low MIC and MBC against KPC compared to Imipenem and Meropenem antibiotics, and promoted better wound closure in rats compared to Imipenem ointment. The biosynthesized ZnO-NPs demonstrated potential for use against bacteria due to their small size, applicability, and low toxicity to human cells.

MOLECULES (2021)

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Article Nanoscience & Nanotechnology

Core-Shell Structured Antimicrobial Nanofiber Dressings Containing Herbal Extract and Antibiotics Combination for the Prevention of Biofilms and Promotion of Cutaneous Wound Healing

Raghavendra Ramalingam et al.

Summary: The study demonstrates that core-shell nanofibers containing plant extracts and antibiotic combinations possess superior antimicrobial properties and promote the spread and proliferation of skin cells, thereby improving the healing process of burn wounds.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Integrative & Complementary Medicine

Review on the Antibacterial Mechanism of Plant-Derived Compounds against Multidrug-Resistant Bacteria (MDR)

Najwan Jubair et al.

Summary: Microbial resistance is rapidly increasing and becoming a leading cause of death worldwide. Plant secondary metabolites are being explored as a potential resource to combat antibiotic-resistant bacteria.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Targeted Delivery of Drugs and Genes Using Polymer Nanocarriers for Cancer Therapy

Wentao Xia et al.

Summary: The application of nanotechnology in cancer therapy has led to significant advancements, with polymer nanoparticles emerging as an innovative non-invasive drug delivery method that improves drug tumor selectivity and reduces toxicity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Silver Nanoparticles and Their Antibacterial Applications

Tamara Bruna et al.

Summary: Silver nanoparticles have excellent antimicrobial properties against a wide range of bacteria, including drug-resistant strains. Research on the synergistic effects of silver nanoparticles with other antibacterial agents for medical applications is ongoing to effectively treat or prevent infections.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Veronika Mikusova et al.

Summary: Polymeric nanoparticles based on chitosan have significant potential as drug carriers due to their beneficial properties, and factors such as cross-linking, morphology, size, density, and drug properties play a crucial role in drug transport and release. Recent research focuses on enhancing chitosan properties and optimizing drug delivery in novel ways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Pharmacology & Pharmacy

Polymeric nanotherapeutics acting at special regions of body

Tivadar Feczko

Summary: Nanoparticulate drug delivery systems with biocompatible polymers as carriers can improve drug stability, activity, and reduce side effects, especially in non-invasive drug delivery routes.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Preparation and Antimicrobial Activity of Chitosan and Its Derivatives: A Concise Review

Luminita Georgeta Confederat et al.

Summary: Biodegradable biopolymers, such as chitosan, have gained significant attention for their environmentally friendly properties and wide range of applications in various economic sectors and medicine. Chitosan, with its biodegradability, biocompatibility, low cost, and multiple pharmacological properties, has sparked strong interest among researchers.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Polymeric Nanoparticles Active against Dual-Species Bacterial Biofilms

Jessa Marie V. Makabenta et al.

Summary: Biofilm infections are a global public health threat that lead to the development and spread of multidrug-resistant bacterial strains. The co-existence of different bacterial species in biofilms exacerbates therapeutic challenges and renders traditional antibiotics ineffective. Polymeric nanoparticles present a potential alternative antimicrobial approach with tunable physico-chemical properties.

MOLECULES (2021)

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Article Chemistry, Physical

Biosynthesis of Silver Nanoparticles Using Stenocereus queretaroensis Fruit Peel Extract: Study of Antimicrobial Activity

Eduardo Padilla-Camberos et al.

Summary: In this study, the phytochemical composition of pitaya peel was evaluated and silver nanoparticles (AgNPs) with potent antimicrobial activity were successfully synthesized using a environmentally friendly biological method. The AgNPs showed strong antimicrobial activity against a variety of bacteria and fungi, suggesting their potential use as disinfectants and in biofilm formulations for packaging products.

MATERIALS (2021)

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Review Microbiology

Fighting Antibiotic Resistance in Hospital-Acquired Infections: Current State and Emerging Technologies in Disease Prevention, Diagnostics and Therapy

Ekaterina Avershina et al.

Summary: Antibiotic resistance is a growing global threat that may result in more deaths than all cancers combined by 2050. Research is focused on the current state of antibiotic resistance, emerging technologies, and strategies for preventing the spread of infectious diseases.

FRONTIERS IN MICROBIOLOGY (2021)

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Review Chemistry, Multidisciplinary

Encapsulation of Pharmaceutical and Nutraceutical Active Ingredients Using Electrospinning Processes

Mina Zare et al.

Summary: Electrospinning is a cost-effective and powerful method for producing nanofibers using a polymer solution and strong electric field, with applications in diverse biological and medical fields. It is particularly promising for manufacturing drug delivery systems due to its large surface area, controllable properties, and high biocompatibility. Electrospinning can improve solubility, bioavailability, and drug targeting, and has also been successful in encapsulating nutraceuticals, such as probiotics.

NANOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

The Antimicrobial and Anti-Inflammatory Effects of Silver Nanoparticles Synthesised from Cotyledon orbiculata Aqueous Extract

Caroline Tyavambiza et al.

Summary: This study demonstrated that AgNPs synthesized from C. orbiculata possess strong antimicrobial and anti-inflammatory properties, especially showing the highest antimicrobial activity against P. aeruginosa.

NANOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

Systematic Evaluation of Antioxidant Efficiency and Antibacterial Mechanism of Bitter Gourd Extract Stabilized Silver Nanoparticles

Kavya Moorthy et al.

Summary: This study focuses on the facile and green synthesis of silver nanoparticles using bitter gourd fruit extract, which exhibit excellent antioxidant and antibacterial properties, showing significant inhibition against drug-resistant bacterial strains.

NANOMATERIALS (2021)

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Review Infectious Diseases

Phytochemicals: A Promising Weapon in the Arsenal against Antibiotic-Resistant Bacteria

Bahman Khameneh et al.

Summary: The widespread use of antibiotics and the rapid emergence of antimicrobial-resistant microbes are becoming major global public health issues. Various solutions have been proposed, including developing alternative compounds with antimicrobial activities, managing existing antimicrobials, and quickly detecting AMR pathogens. Using plant-derived compounds as alternatives appears to be an effective and safe strategy for combating these pathogens, with plenty of commercial products already available on the market.

ANTIBIOTICS-BASEL (2021)

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Article Engineering, Biomedical

Functionalized Antimicrobial Nanofibers: Design Criteria and Recent Advances

Nazirah Hamdan et al.

Summary: This review discusses the emergence of multifunctional polymeric nanofibers as a new tool to combat antibiotic resistance, focusing on design criteria and properties while also presenting progress in utilizing non-antibiotic agents for surface functionalization of antimicrobial nanofibers. Future trends and challenges for polymeric nanofibers are also considered.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2021)

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Proceedings Paper Materials Science, Multidisciplinary

High mobility and size dependent carrier concentration in CdTe nanoparticles synthesized by single injection hydrothermal method for device applications

Meera Ramachandra Gumaste et al.

Summary: In this study, high mobility CdTe nanoparticles were synthesized using the SIH method, with linear dependence between particle size and carrier concentration. Smaller CdTe NPs were found to have higher mobility, and with increasing synthesis duration, p-type conductivity transformed into n-type. The synthesis of CdTe NPs with tunable conductivity may hold promise for device fabrication such as photovoltaic cells.

MATERIALS TODAY-PROCEEDINGS (2021)

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Review Biochemistry & Molecular Biology

Antimicrobial Capacity of Plant Polyphenols against Gram-positive Bacteria: A Comprehensive Review

Francisco Javier Alvarez-Martinez et al.

CURRENT MEDICINAL CHEMISTRY (2020)

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Article Microbiology

Antibacterial, antibiofilm, and antiquorum sensing activities of phytosynthesized silver nanoparticles fabricated from Mespilus germanica extract against multidrug resistance of Klebsiella pneumoniae clinical strains

Fatemeh Foroohimanjili et al.

JOURNAL OF BASIC MICROBIOLOGY (2020)

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Article Biochemistry & Molecular Biology

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Poly(methyl methacrylate) (core) biosurfactant (shell) nanoparticles: Size controlled sub-100 nm synthesis, characterization, antibacterial activity, cytotoxicity and sustained drug release behavior

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Fabrication of Phaeodactylum tricornutum extract-loaded gelatin nanofibrous mats exhibiting antimicrobial activity

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New insights in mechanisms of bacterial inactivation by carvacrol

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Fabrication of pDMAEMA-coated silica nanoparticles and their enhanced antibacterial activity

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Phytochemical and Antibacterial Investigations of the Extracts and Fractions from the Stem Bark of Hymenaea stigonocarpa Mart. ex Hayne and Effect on Ultrastructure of Staphylococcus aureus Induced by Hydroalcoholic Extract

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Modulating Antimicrobial Activity by Synthesis: Dendritic Copolymers Based on Nonquaternized 2-(Dimethylamino)ethyl Methacrylate by Cu-Mediated ATRP

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Stability of Chitosan Nanoparticles Cross-Linked with Tripolyphosphate

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Highly dynamic biodegradable micelles capable of lysing Gram-positive and Gram-negative bacterial membrane

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The molecular mechanism of action of bactericidal gold nanoparticles on Escherichia coli

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Synthesis of metal nanoparticles in living plants

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Antibacterial effect of silver nanoparticles on Staphylococcus aureus

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Correction: Anti-Bacterial Effects of Poly-N-Acetyl-Glucosamine Nanofibers in Cutaneous Wound Healing: Requirement for Akt1

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PLoS One (2011)

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Polymer nanoparticles: Preparation techniques and size-control parameters

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Electrospinning of polysaccharides for regenerative medicine

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EFFECT OF CHARGE DENSITY ON THE TAYLOR CONE IN ELECTROSPINNING

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The battle against multi-resistant strains: Renaissance of antimicrobial essential oils as a promising force to fight hospital-acquired infections

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Effects of tannins and related polyphenols on methicillin-resistant Staphylococcus aureus

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PHYTOCHEMISTRY (2005)

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Bacterial mechanisms to overcome inhibitory effects of dietary tannins

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MICROBIAL ECOLOGY (2005)

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Influence of satellite groups on telechelic antimicrobial functions of polyoxazolines

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MACROMOLECULAR BIOSCIENCE (2005)

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