期刊
POLYMERS
卷 15, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/polym15071739
关键词
block copolymer; barium carbonate; hollow particles; drug delivery; micelles
A laboratory-synthesized triblock copolymer was used as a template to synthesize hollow BaCO3 nanoparticles. The formation of spherical micelles with a PEG corona, PAA shell, and PS core in an aqueous solution was confirmed. The controlled precipitation of BaCO3 around the polymeric micelles allowed for the synthesis of hollow BC-NPs with specific properties.
A laboratory-synthesized triblock copolymer poly(ethylene oxide-b-acrylic acid-b-styrene) (PEG-PAA-PS) was used as a template to synthesize hollow BaCO3 nanoparticles (BC-NPs). The triblock copolymer was synthesized using reversible addition-fragmentation chain transfer radical polymerization. The triblock copolymer has a molecular weight of 1.88 x 10(4) g/mol. Transmission electron microscopy measurements confirm the formation of spherical micelles with a PEG corona, PAA shell, and PS core in an aqueous solution. Furthermore, the dynamic light scattering experiment revealed the electrostatic interaction of Ba2+ ions with an anionic poly(acrylic acid) block of the micelles. The controlled precipitation of BaCO3 around spherical polymeric micelles followed by calcination allows for the synthesis of hollow BC-NPs with cavity diameters of 15 nm and a shell thickness of 5 nm. The encapsulation and release of methotrexate from hollow BC-NPs at pH 7.4 was studied. The cell viability experiments indicate the possibility of BC-NPs maintaining biocompatibility for a prolonged time.
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