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Smart Dental Materials Intelligently Responding to Oral pH to Combat Caries: A Literature Review

POLYMERS (2023)

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Article Engineering, Biomedical

Dental plaque-inspired versatile nanosystem for caries prevention and tooth restoration

Yue Xu et al.

Summary: A stimuli-responsive multidrug delivery system has been developed in this study, which can prevent tooth decay and promote enamel restoration. The system can identify cariogenic conditions, intelligently release drugs, and restore the microarchitecture and mechanical properties of demineralized teeth.

BIOACTIVE MATERIALS (2023)

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Review Immunology

The application of mesoporous silica nanoparticles as a drug delivery vehicle in oral disease treatment

Lixin Fang et al.

Summary: Mesoporous silica nanoparticles (MSNs) show promise as safer and more effective medication delivery vehicles for treating oral disorders. They effectively combine with various medications to overcome systemic toxicity and low solubility issues. As a common nanoplatform, MSNs increase therapy effectiveness and have potential in combating antibiotic resistance.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2023)

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Article Engineering, Biomedical

Smart dental materials for antimicrobial applications

Carolina Montoya et al.

Summary: Smart biomaterials that can sense and react to physiological or external environmental stimuli have seen significant growth in the field of dentistry for antimicrobial applications. These biomaterial systems offer improved efficacy and controllable bio-functionalities to prevent infections and extend the lifespan of dental devices. This review article presents the current state-of-the-art and limitations of bioactive and stimuli-responsive dental materials, and discusses their antimicrobial mechanisms, applications, and potential obstacles in developing clinically relevant technologies.

BIOACTIVE MATERIALS (2023)

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Article Pharmacology & Pharmacy

Effect of pH-sensitive nanoparticles on inhibiting oral biofilms

Xinyu Peng et al.

Summary: Dental caries is a preventable infectious disease caused by interactions between oral bacteria and dietary sugars. pH-sensitive drug delivery systems have become innovative materials for caries prevention. In this study, a pH-sensitive carrier (poly(DMAEMA-co-HEMA)) was used to synthesize a nanomaterial loaded with chlorhexidine (p(DH)@CHX), which exhibited good pH sensitivity and sustained release of CHX in an acidic environment. It showed lower cytotoxicity than free CHX and had the same antibacterial effects on biofilms. In addition, it had the potential to alter oral microbiota composition and reduce caries risk.

DRUG DELIVERY (2022)

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Article Engineering, Biomedical

pH and lipase-responsive nanocarrier-mediated dual drug delivery system to treat periodontitis in diabetic rats

Lu Wang et al.

Summary: This study designed a novel dual responsive and dual drug-loading nanocarrier system for precise and controlled drug delivery to treat periodontitis in patients with diabetes. In vitro and in vivo studies confirmed the effectiveness of this nanocarrier, which can inhibit the formation of subgingival microbial colonies and promote osteogenic differentiation of cells, ameliorating periodontal bone resorption.

BIOACTIVE MATERIALS (2022)

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Article Dentistry, Oral Surgery & Medicine

Ion release and hydroxyapatite precipitation of resin composites functionalized with two types of bioactive glass

Matej Par et al.

Summary: The experimental composites containing bioactive glass and selected commercial materials demonstrated the potential for releasing multiple ion types and increasing pH, which is clinically significant for preventing demineralization and promoting remineralization.

JOURNAL OF DENTISTRY (2022)

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Article Immunology

Novel dental resin infiltrant containing smart monomer dodecylmethylaminoethyl methacrylate

Xiaoyu Huang et al.

Summary: By incorporating DMAEM into a resin infiltrant, white spot lesions can be effectively inhibited and enamel hardness can be improved, without increasing cytotoxicity. In addition, DMAEM has antibacterial effects, reducing biofilm metabolic activity and lactic acid production.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Fabrication of pH-Responsive Zn2+-Releasing Glass Particles for Smart Antibacterial Restoratives

Fan Deng et al.

Summary: This study fabricated pH-responsive Zn2+-releasing glass particles and evaluated their solubilities, ion-releasing characteristics, and antibacterial properties. The solubility and concentration of Zn2+ released in the medium increased with a decrease in medium pH. Glass particles with higher zinc content demonstrated higher concentrations of released Zn2+ and exhibited good antibacterial effects even under acidic conditions, which may contribute to the prevention of diseases with lower acid resistance.

MOLECULES (2022)

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Article Microbiology

Effects of a Novel, Intelligent, pH-Responsive Resin Adhesive on Cariogenic Biofilms In Vitro

Yangyang Shi et al.

Summary: The study found that DMAEM@RA had a pH-responsive antimicrobial effect on Streptococcus mutans and Candida albicans dual-species biofilms, preventing secondary caries and attenuating cariogenic virulence.

PATHOGENS (2022)

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Review Engineering, Biomedical

Application of bioactive glasses in various dental fields

Nazanin Jafari et al.

Summary: Bioactive glasses are bioceramic materials widely used in medicine and dentistry due to their high biocompatibility, antimicrobial features, and bioactivity. They are applied in various dental treatments and products, including dental implants. Marine sponges have been recently recognized as a rich source of bioactive glasses, thanks to their mineral contents and compounds with medicinal properties.

BIOMATERIALS RESEARCH (2022)

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Article Medicine, Research & Experimental

Dual-sensitive antibacterial peptide nanoparticles prevent dental caries

Peng Zhang et al.

Summary: This study reports dual-sensitive antibacterial peptide nanoparticles for the treatment of dental caries. The nanoparticles showed high efficacy in killing cariogenic bacteria in acidic environments without harming normal oral microbiota. In vivo experiments also demonstrated the superior anti-caries effect of the nanoparticles compared to clinical agents.

THERANOSTICS (2022)

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Article Engineering, Biomedical

Low-shrinkage-stress nanocomposite: An insight into shrinkage stress, antibacterial, and ion release properties

Ghalia Bhadila et al.

Summary: The study aimed to develop a novel bioactive nanocomposite with low shrinkage stress, strong antibiofilm activity, and high levels of ion release for remineralization, without compromising mechanical properties and degree of conversion.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2021)

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Article Dentistry, Oral Surgery & Medicine

Intelligent pH-responsive dental sealants to prevent long-term microleakage

Hao Li et al.

Summary: The DMAEM-modified sealants showed promising long-term antibacterial activities against oral microbial-aging and long-term microecosystem-regulating capabilities, resulting in a significant reduction in microleakage and potential prevention of dental caries without affecting the depth-of-cure values and cytotoxicity of the sealants.

DENTAL MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Mutanofactin promotes adhesion and biofilm formation of cariogenic Streptococcus mutans

Zhong-Rui Li et al.

Summary: The study identified a biosynthetic gene cluster in Cariogenic Streptococcus mutans that directly correlates with strong biofilm formation, leading to the discovery of a bioactive product mutanofactin-697. This product was found to increase bacterial hydrophobicity, promote bacterial adhesion, and enhance biofilm formation, highlighting the importance of microbial secondary metabolism in dental caries development processes.

NATURE CHEMICAL BIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

pH-dependent delivery of chlorhexidine from PGA grafted mesoporous silica nanoparticles at resin-dentin interface

Zohaib Akram et al.

Summary: The study synthesized and characterized chlorhexidine-loaded mesoporous silica nanoparticles grafted with poly-L-glycolic acid, and tested their in vitro drug release, cytotoxicity, and antimicrobial capacity in different pH environments. The experimental nanoparticles demonstrated low cytotoxicity and high antibacterial efficacy, showing potential for use in adhesive and restorative dentistry.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Microbiology

A New pH-Responsive Nano Micelle for Enhancing the Effect of a Hydrophobic Bactericidal Agent on Mature Streptococcus mutans Biofilm

Meng Zhang et al.

Summary: Nano drug-delivery materials play a crucial role in enhancing biofilm penetrability and drug bioavailability, showing great potential in preventing biofilm-related diseases such as periodontitis. The pH-responsive nano micelle synthesized in this study has the ability to deliver hydrophobic antibacterial agents effectively in acidic environments, with no cytotoxic effects on periodontal cells observed within 48 hours.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Chemistry, Multidisciplinary

pH-Sensitive Chitosan Nanoparticles for Salivary Protein Delivery

Yi Zhu et al.

Summary: Salivary proteins like histatins play important roles in tooth health. Chitosan nanoparticles show promise in protecting these proteins from enzymatic degradation in the oral environment, especially in acidic conditions. The results demonstrate their potential as carriers for oral applications.

NANOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Porous bioactive glass micro- and nanospheres with controlled morphology: developments, properties and emerging biomedical applications

Kai Zheng et al.

Summary: Porous bioactive glass micro/nanospheres (PBGSs) have emerged as attractive biomaterials in biomedical applications, with controllable particle size and pore structure critical for their functionality. Sol-gel processing is the primary method used for PBGSs synthesis, allowing for control over the chemical compositions and pore structures. Recent progress has been made in the synthesis of PBGSs with sophisticated pore structures, and their achievements in bone tissue regeneration, wound healing, drug delivery, bioimaging, and cancer therapy have been highlighted.

MATERIALS HORIZONS (2021)

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Review Chemistry, Physical

Commercially Available Fluoride-Releasing Restorative Materials: A Review and a Proposal for Classification

Philippe Francois et al.

MATERIALS (2020)

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Article Nanoscience & Nanotechnology

Zinc-Calcium-Fluoride Bioglass-Based Innovative Multifunctional Dental Adhesive with Thick Adhesive Resin Film Thickness

Chenmin Yao et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

Bioactive low-shrinkage-stress nanocomposite suppresses S. mutans biofilm and preserves tooth dentin hardness

Ghalia Bhadila et al.

ACTA BIOMATERIALIA (2020)

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Article Dentistry, Oral Surgery & Medicine

In vitro evaluation of composite containing DMAHDM and calcium phosphate nanoparticles on recurrent caries inhibition at bovine enamel-restoration margins

Wen Zhou et al.

DENTAL MATERIALS (2020)

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Article Biotechnology & Applied Microbiology

Farnesal-loaded pH-sensitive polymeric micelles provided effective prevention and treatment on dental caries

Youping Yi et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Article Dentistry, Oral Surgery & Medicine

pH-Responsive Antibacterial Resin Adhesives for Secondary Caries Inhibition

J. Liang et al.

JOURNAL OF DENTAL RESEARCH (2020)

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Article Dentistry, Oral Surgery & Medicine

Antibacterial and remineralizing nanocomposite inhibit root caries biofilms and protect root dentin hardness at the margins

Wen Zhou et al.

JOURNAL OF DENTISTRY (2020)

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Article Dentistry, Oral Surgery & Medicine

Novel low-shrinkage-stress nanocomposite with remineralization and antibacterial abilities to protect marginal enamel under biofilm

Ghalia Bhadila et al.

JOURNAL OF DENTISTRY (2020)

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Article Biochemistry & Molecular Biology

Novel Nanocomposite Inhibiting Caries at the Enamel Restoration Margins in an In Vitro Saliva-Derived Biofilm Secondary Caries Model

Wen Zhou et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Chemistry, Multidisciplinary

Novel Crown Cement Containing Antibacterial Monomer and Calcium Phosphate Nanoparticles

Rashed AlSahafi et al.

NANOMATERIALS (2020)

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Review Engineering, Biomedical

Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials

Leopoldo Torres et al.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2020)

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Review Dentistry, Oral Surgery & Medicine

Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles

Kunneng Liang et al.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2019)

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Article Chemistry, Physical

The importance of being amorphous: calcium and magnesium phosphates in the human body

Rita Gelli et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2019)

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Article Biophysics

An enzyme-responsive membrane for antibiotic drug release and local periodontal treatment

Ning Li et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Materials Science, Biomaterials

pH-Responsive polymeric nanocarriers for efficient killing of cariogenic bacteria in biofilms

Zhouxiang Zhao et al.

BIOMATERIALS SCIENCE (2019)

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Article Microbiology

The Biology of Streptococcus mutans

J. A. Lemos et al.

MICROBIOLOGY SPECTRUM (2019)

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Article Engineering, Biomedical

Responsive antimicrobial dental adhesive based on drug-silica co-assembled particles

Cameron A. Stewart et al.

ACTA BIOMATERIALIA (2018)

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Review Dentistry, Oral Surgery & Medicine

Antibacterial quaternary ammonium compounds in dental materials: A systematic review

Pooyan Makvandi et al.

DENTAL MATERIALS (2018)

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Article Dentistry, Oral Surgery & Medicine

Novel magnetic nanoparticle-containing adhesive with greater dentin bond strength and antibacterial and remineralizing capabilities

Yuncong Li et al.

DENTAL MATERIALS (2018)

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Article Dentistry, Oral Surgery & Medicine

Protein-repellent nanocomposite with rechargeable calcium and phosphate for long-term ion release

Yousif A. Al-Dulaijan et al.

DENTAL MATERIALS (2018)

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Article Dentistry, Oral Surgery & Medicine

Protein-repelling adhesive resin containing calcium phosphate nanoparticles with repeated ion-recharge and re-releases

Faisal D. al-Qarni et al.

JOURNAL OF DENTISTRY (2018)

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Article Nanoscience & Nanotechnology

Redox/pH dual-controlled release of chlorhexidine and silver ions from biodegradable mesoporous silica nanoparticles against oral biofilms

Meng-meng Lu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Review Cell & Tissue Engineering

Advanced smart biomaterials and constructs for hard tissue engineering and regeneration

Ke Zhang et al.

BONE RESEARCH (2018)

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Article Dentistry, Oral Surgery & Medicine

A new arginine-based dental adhesive system: formulation, mechanical and anti-caries properties

Saulo Geraldeli et al.

JOURNAL OF DENTISTRY (2017)

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Article Medicine, General & Internal

Dental caries

Nigel B. Pitts et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

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Article Dentistry, Oral Surgery & Medicine

Novel dental adhesive with triple benefits of calcium phosphate recharge, protein-repellent and antibacterial functions

Xianju Xie et al.

DENTAL MATERIALS (2017)

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Article Dentistry, Oral Surgery & Medicine

Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement

Xian-Ju Xie et al.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2017)

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Article Chemistry, Multidisciplinary

Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates

Leanna R. Staben et al.

NATURE CHEMISTRY (2016)

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Article Materials Science, Biomaterials

Characterization and optimization of pH-responsive polymer nanoparticles for drug delivery to oral biofilms

Jiayi Zhou et al.

JOURNAL OF MATERIALS CHEMISTRY B (2016)

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Article Dentistry, Oral Surgery & Medicine

Effects of quaternary ammonium chain length on the antibacterial and remineralizing effects of a calcium phosphate nanocomposite

Ke Zhang et al.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2016)

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Article Chemistry, Multidisciplinary

pH-Activated Nanoparticles for Controlled Topical Delivery of Farnesol To Disrupt Oral Biofilm Virulence

Benjamin Horev et al.

ACS NANO (2015)

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Article Dentistry, Oral Surgery & Medicine

Rechargeable dental adhesive with calcium phosphate nanoparticles for long-term ion release

Ling Zhang et al.

JOURNAL OF DENTISTRY (2015)

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Article Medicine, Research & Experimental

pH-Triggered Controllable Release of Silver-Indole-3 Acetic Acid Complexes from Mesoporous Silica Nanoparticles (IBN-4) for Effectively Killing Malignant Bacteria

Yaswanth Kuthati et al.

MOLECULAR PHARMACEUTICS (2015)

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Review Biochemistry & Molecular Biology

Solving the etiology of dental caries

Aurea Simon-Soro et al.

TRENDS IN MICROBIOLOGY (2015)

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Article Dentistry, Oral Surgery & Medicine

Functionalizing a dentin bonding resin to become bioactive

Tobias T. Taubock et al.

DENTAL MATERIALS (2014)

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Article Dentistry, Oral Surgery & Medicine

Nanocomposite containing CaF2 nanoparticles: Thermal cycling, wear and long-term water-aging

Michael D. Weir et al.

DENTAL MATERIALS (2012)

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Article Engineering, Biomedical

Long-term mechanical durability of dental nanocomposites containing amorphous calcium phosphate nanoparticles

Jennifer L. Moreau et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2012)

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Article Dentistry, Oral Surgery & Medicine

Smart materials in dentistry

J. F. McCabe et al.

AUSTRALIAN DENTAL JOURNAL (2011)

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Article Dentistry, Oral Surgery & Medicine

Nanocomposite containing amorphous calcium phosphate nanoparticles for caries inhibition

Hockin H. K. Xu et al.

DENTAL MATERIALS (2011)

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Article Engineering, Biomedical

Mechanical and acid neutralizing properties and bacteria inhibition of amorphous calcium phosphate dental nanocomposite

Jennifer L. Moreau et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2011)

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Review Engineering, Biomedical

Apatite-formation ability - Predictor of bioactivity?

Haobo Pan et al.

ACTA BIOMATERIALIA (2010)

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Article Dentistry, Oral Surgery & Medicine

Calcium and phosphate ion releasing composite: Effect of pH on release and mechanical properties

Hockin H. K. Xu et al.

DENTAL MATERIALS (2009)

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Article Dentistry, Oral Surgery & Medicine

Effect of pH on the wettability and fluoride release of an ion-releasing resin composite

F. M. Namen et al.

OPERATIVE DENTISTRY (2008)

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Article Engineering, Biomedical

Amorphous calcium phosphate/urethane methacrylate resin composites. I. Physicochemical characterization

William F. Regnault et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2008)

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Article Dentistry, Oral Surgery & Medicine

Mechanical properties and biochemical activity of remineralizing resin-based Ca-PO4 cements

SH Dickens et al.

DENTAL MATERIALS (2003)

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Article Dentistry, Oral Surgery & Medicine

The pH of dental plaque in its relation to early enamel caries and dental plaque flora in humans

P Lingström et al.

JOURNAL OF DENTAL RESEARCH (2000)

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