4.7 Article

Regulation of PKR-dependent RNA translation inhibition by TRIM21 upon virus infection or other stress

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Cell Biology

Cellular origins of dsRNA, their recognition and consequences

Y. Grace Chen et al.

Summary: DSRNA, whether of viral origin or endogenous, can lead to immune disorders or be utilized for immunotherapy. Organisms have mechanisms to recognize and respond to dsRNA to minimize potential infections, with infected and dysregulated cells both triggering immune responses.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Article Biochemistry & Molecular Biology

Cell fate determined by the activation balance between PKR and SPHK1

Han Qiao et al.

Summary: This study reveals the crucial role of phosphorylation interplay between SPHK1 and PKR in regulating cell survival and death during cellular stress response.

CELL DEATH AND DIFFERENTIATION (2021)

Review Virology

TRIMming Type I Interferon-Mediated Innate Immune Response in Antiviral and Antitumor Defense

Ling Wang et al.

Summary: The TRIM family comprises at least 80 members in humans, with most having ubiquitin or SUMO E3 ligase activity conferred by their N-terminal RING domain. TRIMs play important roles in regulating a wide range of biological processes such as viral infections, autophagy, cell cycle, etc., with their E3 ligase activities being attractive targets for developing specific immunotherapeutic strategies.

VIRUSES-BASEL (2021)

Article Biochemistry & Molecular Biology

MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria

Mansoor Hussain et al.

Summary: Mutations in Pol gamma A gene lead to PEO, which can be negatively regulated by ubiquitylation by MITOL, causing impaired mitochondrial entry. Some PEO patients' Pol gamma A variants are heavily ubiquitylated, preventing mitochondrial entry.

PLOS BIOLOGY (2021)

Review Immunology

Interplay Between Non-Canonical NF-κB Signaling and Hepatitis B Virus Infection

Xinyu Lu et al.

Summary: The non-canonical NF-kappa B signaling pathway is crucial in HBV infection, influencing host immune responses, viral replication, and liver damage. Understanding the interaction between HBV and this pathway may lead to the discovery of potential therapeutic targets and drugs for treating HBV infection.

FRONTIERS IN IMMUNOLOGY (2021)

Article Pharmacology & Pharmacy

E3 ubiquitin ligase TRIM21 restricts hepatitis B virus replication by targeting HBx for proteasomal degradation

Yahui Song et al.

Summary: TRIM21 restricts HBV replication by targeting the HBx-Smc5/6 pathway, leading to impaired HBx-mediated degradation of Smc6 and suppression of HBV replication. Over-expression or knocking-out of TRIM21 shows an in vivo therapeutic effect in HBV-infected models.

ANTIVIRAL RESEARCH (2021)

Review Immunology

TRIM21/Ro52-Roles in Innate Immunity and Autoimmune Disease

Esther L. Jones et al.

Summary: TRIM21 is an E3 ubiquitin ligase with crucial roles in immune host defence, signal transduction, and potentially cell cycle regulation. It is also a target of autoantibodies in Sjogren's syndrome, systemic lupus erythematosus, and other rheumatic autoimmune diseases.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

RIG-I-like receptors: their regulation and roles in RNA sensing

Jan Rehwinkel et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Biochemistry & Molecular Biology

Visualizing ubiquitination in mammalian cells

Sjoerd J. L. van Wijk et al.

EMBO REPORTS (2019)

Article Biochemistry & Molecular Biology

PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs

Yoosik Kim et al.

MOLECULAR CELL (2018)

Article Oncology

Successful Treatment of HIV-Associated Kaposi Sarcoma with Immune Checkpoint Blockade

Natalie Galanina et al.

CANCER IMMUNOLOGY RESEARCH (2018)

Article Microbiology

The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry

Tomas Doyle et al.

NATURE MICROBIOLOGY (2018)

Article Microbiology

KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation

Nishi R. Sharma et al.

PLOS PATHOGENS (2017)

Article Biochemistry & Molecular Biology

Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA

Alexandre Dalet et al.

EMBO JOURNAL (2017)

Review Biochemistry & Molecular Biology

The integrated stress response

Karolina Pakos-Zebrucka et al.

EMBO REPORTS (2016)

Review Immunology

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

Jiaxi Wu et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

Article Biochemistry & Molecular Biology

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

Thomas M. Durcan et al.

EMBO JOURNAL (2014)

Article Virology

Epstein-Barr Virus Essential Antigen EBNA3C Attenuates H2AX Expression

Hem C. Jha et al.

JOURNAL OF VIROLOGY (2014)

Review Biochemistry & Molecular Biology

New insights into ubiquitin E3 ligase mechanism

Christopher E. Berndsen et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

Complete replication of hepatitis B virus and hepatitis C virus in a newly developed hepatoma cell line

Darong Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA

Megumi Tatematsu et al.

NATURE COMMUNICATIONS (2013)

Article Multidisciplinary Sciences

Novel role of PKR in inflammasome activation and HMGB1 release

Ben Lu et al.

NATURE (2012)

Article Multidisciplinary Sciences

AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization

Felix Hauler et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits

Nicolas Chevrier et al.

Review Biochemistry & Molecular Biology

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

Goekhan S. Hotamisligil

Review Virology

Activation of the Antiviral Kinase PKR and Viral Countermeasures

Bianca Dauber et al.

VIRUSES-BASEL (2009)

Article Multidisciplinary Sciences

Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway

Z Tallóczy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)