期刊
PLOS COMPUTATIONAL BIOLOGY
卷 19, 期 3, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pcbi.1010920
关键词
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This study presents a multiagent-based model that captures the interactions between different types of cells with their microenvironment, and enables the analysis of the emergent global behavior during tissue regeneration and tumor development. By tuning the system with the characteristics of the individual patients, the model reproduces a variety of spatial patterns of tissue regeneration and tumor growth, resembling those found in clinical imaging or biopsies. In the clinical context, the model is able to predict the recurrence of a hepatocellular carcinoma after a 70% partial hepatectomy.
We present a multiagent-based model that captures the interactions between different types of cells with their microenvironment, and enables the analysis of the emergent global behavior during tissue regeneration and tumor development. Using this model, we are able to reproduce the temporal dynamics of regular healthy cells and cancer cells, as well as the evolution of their three-dimensional spatial distributions. By tuning the system with the characteristics of the individual patients, our model reproduces a variety of spatial patterns of tissue regeneration and tumor growth, resembling those found in clinical imaging or biopsies. In order to calibrate and validate our model we study the process of liver regeneration after surgical hepatectomy in different degrees. In the clinical context, our model is able to predict the recurrence of a hepatocellular carcinoma after a 70% partial hepatectomy. The outcomes of our simulations are in agreement with experimental and clinical observations. By fitting the model parameters to specific patient factors, it might well become a useful platform for hypotheses testing in treatments protocols. Author summaryWe introduce an off-lattice agent-based model to simulate tissue-scale features that emerge from basic biological and biophysical cell processes. In order to calibrate and validate our model, we have considered the liver regeneration response after a 30% partial hepatectomy in which the liver recovers its original volume due to the hypertrophy of the hepatocytes. Subsequently, we have modeled the same process but after a 70% partial hepatectomy, in which the liver recovers its original volume due to the hypertrophy and the proliferation of the hepatocytes. Unfortunately, the precise mechanisms of initiating, promoting and terminating regenerative responses remain unknown. As a consequence, we have proposed a modeling approach in which such processes are regulated by a hypothetical substrate that diffuses in the cell microenvironment. As a further test, we have, in one hand, implemented our model to predict the liver response after a 50% partial hepatectomy and, on the other hand, explored our model's ability to account for the recurrence of a hepatocellular carcinoma. The outcomes of our simulations agree with experimental data and clinical observations, which comes to underline the significant descriptive and predictive power of this computational approach. Even though our model needs to be further extended to incorporate patient specific clinical data, these results are a promising step in the direction of a personalized estimation of tissue dynamics from a limited number of measurements carried out at diagnosis.
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