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Article
Biotechnology & Applied Microbiology
Yuanwen Jiang et al.
Summary: Smart bandages based on multimodal wearable devices have the potential to monitor and intervene in the healing process of chronic wounds. However, the integration of sensors and stimulators in current smart bandage technologies is limited. In this study, a flexible bioelectronic system with wireless power, closed-loop sensing and stimulation circuits, and skin-interfacing hydrogel electrodes with switchable adhesion was developed to address these challenges. The wound care system showed improved healing and tissue regeneration in preclinical wound models.
NATURE BIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Qiankun Zeng et al.
Summary: This article reviews the importance of wound dressings based on nanomaterials in wound treatment and highlights their functional advantages and smart development trends. It also explores the challenges and opportunities associated with nanomaterial-based wound dressings in clinical practice.
Article
Chemistry, Multidisciplinary
Gang Li et al.
Summary: Conducting polymer hydrogels have great potential in soft bioelectronics due to their tissue-like mechanical properties and electrical interaction with tissues. However, balancing electrical conductivity and mechanical stretchability is challenging. This study addresses the issue by concentrating a poorly crosslinked precursor hydrogel with a high content ratio of the conducting polymer, resulting in a densified double-network hydrogel with high electrical conductivity and large fracture strain. The hydrogel also exhibits high biocompatibility, tissue-like softness, low swelling ratio, and desired electrochemical properties for bioelectronics. Surface grafting is used to form an adhesive layer on the conducting hydrogel, enabling robust bonding on tissues. The proposed hydrogel is applied for physiological signal recording and electrical stimulation with an in vivo rat model, showing high quality and reliability. This method provides an ideal strategy for rapid and reliable tissue-device integration with high-quality electrical communications.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Ning Tang et al.
Summary: The study introduces a novel self-healing, antibacterial, and multifunctional wound dressing for sutureless wound closure and real-time monitoring. The dressing features high mechanical toughness, biocompatibility, and outstanding antibacterial activity, effectively inhibiting bacterial growth and accelerating healing. In vivo tests demonstrate that the dressing can help in wound closure and deposition of collagen, while the integrated sensor array provides real-time monitoring of temperature, pH, and glucose levels in the wound area. Ultimately, this multifunctional dressing would be valuable for personalized monitoring and treatment approaches in wound healing management.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Mengzhuan Lin et al.
Summary: A hydrogen bond cross-linked network based on XSBR and SS non-covalently modified CNTs has been designed and fabricated into multi-functional sensors, with high stretchability, strength, and sensitivity, as well as the ability to measure body temperature.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Huanhuan Chen et al.
Summary: The hydrogen-producing hydrogel made of living Chlorella and bacteria within a cell-impermeable casing can continuously produce hydrogen for 60 hours, selectively reduce highly toxic ·OH and ONOO- species, and reduce inflammation. Studies have shown that the microbe-hydrogel dressing can promote cell proliferation and diabetic wound healing by almost 50% at day 3. This symbiotic algae-bacteria hydrogel demonstrates excellent biocompatibility and reactive oxygen species scavenging capabilities, suggesting great promise for clinical use.
Review
Nanoscience & Nanotechnology
Rui Yu et al.
Summary: This review summarizes the design and application of conductive biomaterials for wound healing and skin tissue engineering. Conductive biomaterials with various structural forms, such as films, nanofibers, membranes, hydrogels, sponges, foams, and acellular dermal matrix, play important roles in electrotherapy, wound dressing, and wound assessment, and possess promising applications in the field.
NANO-MICRO LETTERS
(2022)
Article
Multidisciplinary Sciences
Foad Vashahi et al.
Summary: Researchers have developed an injectable hydrogel material with softness and firmness that matches tissue, making it suitable for biomedical applications.
Article
Chemistry, Multidisciplinary
Yang Li et al.
Summary: This study develops an injectable hydrogel based on MXene nanosheets for diabetic wound healing. The hydrogel utilizes oxyhemoglobin to release oxygen controllably and MXene to scavenge reactive oxygen species and bacteria. The hydrogel also benefits from the regulation of macrophage polarization. Overall, it effectively promotes the healing of infected diabetic wounds.
Article
Chemistry, Multidisciplinary
Qi Lei et al.
Summary: In this study, a functional microneedle based on hyaluronic acid was developed for concurrent tumor photothermal therapy and skin tissue regeneration to address the problem of delayed wound healing after skin tumor resection. Natural melanin nanoparticles derived from cuttlefish ink were used to scavenge ROS and implement photothermal therapy, and these nanoparticles were encapsulated within an amorphous silica shell to stimulate skin tissue regeneration. The functional microneedle exhibited high biocompatibility and feasibility, making it a promising supplementary therapy for skin tumor resection.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yuna Qian et al.
Summary: A novel glycyrrhizic acid-based hybrid hydrogel dressing with intrinsic immunoregulatory properties is developed to promote rapid diabetic wound healing.
ADVANCED MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Wentao Cao et al.
Summary: This paper presents a bioinspired user-interactive electronic skin that can convert mechanical stimuli into digital electrical response and optical visualization. The e-skin has a simple structure and reliable operation, enabling it to monitor human activities in a more intuitive and accurate way.
NANO-MICRO LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Li-Wei Lo et al.
Summary: This article introduces an elastomeric sponge electrode that significantly reduces electrode-skin contact impedance and improves signal-to-noise ratio (SNR), making it ideal for long-term and motion-artifact-tolerant recording of high-quality biopotential signals. The sponge electrode is made from a porous polydimethylsiloxane sponge and coated with a conductive polymer, and it shows great potential for wearable health monitoring applications.
Article
Chemistry, Multidisciplinary
Jing Liu et al.
Summary: In this study, a multimodal hydrogel sensor with excellent comprehensive performance was developed for monitoring respiration and diagnosing obstructive sleep apnea syndrome (OSAS). The hydrogel sensor exhibited good mechanical properties and extreme temperature tolerance, enabling independent monitoring of mechanical variation and thermal change. This sensor provides a new and practical way for real-time respiratory monitoring and preventing the occurrence of sleep-related diseases.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Polymer Science
Xiaoliang Qi et al.
Summary: This study reports the facile synthesis of a polyphenol/polysaccharide hydrogel for the treatment of diabetic wounds by scavenging ROS. The hydrogel showed antioxidant properties and could be strengthened by local photothermal heating, providing enhanced protection against oxidative damage.
Article
Nanoscience & Nanotechnology
Junshi Li et al.
Summary: The researchers have developed a flexible MNA electrode that can fit a curved body surface, penetrate the skin without fracture, and be mass-produced with a simplified process. The electrode is compatible with wearable wireless systems and has a short preparation time, improving the comfort and convenience of electrophysiological recording.
NANO-MICRO LETTERS
(2022)
Article
Multidisciplinary Sciences
Wenshuai Liu et al.
Summary: A glycopeptide hybrid hydrogel with antibacterial and tissue environment-responsive properties was developed for chronic wound healing. The hydrogel can promote cell proliferation and macrophage polarization, and has potent antibacterial effects. It accelerated the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic and scalding skin by promoting M2-type macrophages, reducing inflammation, and promoting angiogenesis.
Article
Chemistry, Multidisciplinary
Hao Tang et al.
Summary: This study proposes in situ forming hydrogel electrodes or electronics (ISF-HEs) that can establish conformal interfaces on biological surfaces, allowing accurate monitoring of human motions and physiological signals with reduced motion artifact interference.
Article
Nanoscience & Nanotechnology
Yuqing Liang et al.
Summary: This article introduces a multifunctional hydrogel adhesive prepared by a bioinspired dynamic bond cross-linking method, which can be used for seamless wound closure and wound healing. The hydrogel has sufficient mechanical and adhesive strength, as well as injectability and self-healing capacity, which can effectively close wounds and repeatedly close reopened wounds. In addition, it also has good biocompatibility, antibacterial activity, and hemostatic effect.
NANO-MICRO LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Qiankun Zeng et al.
Summary: A multifunctional bilayer wound patch is developed by integrating a debonding-on-demand polymeric tissue adhesive with an ionic conducting elastomer. The patch has temperature-triggered adhesion and non-forced detachment properties, preventing blood infiltration and clot formation, and providing a reliable treatment method.
Article
Chemistry, Multidisciplinary
Mengting Yin et al.
Summary: The MN-MOF-GO-Ag microneedle patch combines magnesium organic frameworks with graphene oxide-silver nanocomposites for diabetic wound healing, promoting cell migration and antioxidation by releasing magnesium ions and gallic acid, as well as providing excellent antibacterial effects.
Review
Chemistry, Multidisciplinary
Aziz Maleki et al.
Summary: Light-based photothermal therapy (PTT) and photo-dynamic therapy (PDT) have great potential in wound healing and infection prevention. Multifunctional photoresponsive hydrogels (MPRHs) combining light and hydrogel advantages are increasingly used in biomedicine, particularly in wound repair. The modulation of bacterial microenvironments to inhibit infection through PTT, PDT, and photothermal/photodynamic synergistic therapy has been discussed.
Review
Agriculture, Multidisciplinary
Shuxin Ye et al.
Summary: This review discusses the application of konjac glucomannan (KGM) in the food industry, including its sources, production, purification process, and regulatory requirements in different countries. The study explores the structural information, gelation mechanisms, degraded derivatives, cryoprotection effect, and nutritional value of KGM, providing theoretical guidance for designing KGM-based products.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Zhanrong Jia et al.
Summary: Conductive silk microfibers were fabricated using a bioinspired method in this study, which were then used to make a conductive flexible silk fibroin patch for monitoring physiological signals and promoting chronic diabetic wound healing with excellent performance.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Hui Zhang et al.
Summary: In this study, Gel-DA was used as a biotemplate to synthesize Gel-DA@Ag NPs with antioxidant activity and NIR laser irradiation synergistic antibacterial behavior for the first time. These NPs were then incorporated into guar gum based hydrogels to achieve remolding, injectable, and self-healing properties. The multifunctional hydrogels demonstrated the ability to completely cover irregular wound shapes and accelerate wound healing under NIR, with the appearance of skin appendages like hair follicles and blood vessels.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Yongping Liang et al.
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Article
Chemistry, Multidisciplinary
Xin Peng et al.
Summary: The PEI/PAA/QCS powder is an ultrafast self-gelling and wet adhesive hemostatic material that can quickly absorb blood and form a pressure-resistant physical barrier to stop bleeding effectively. It has been demonstrated to work well on various irregularly shaped, high-pressure bleeding wounds and can also promote wound healing.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Biomedical
Ning Tang et al.
Summary: Smart wound dressings integrated with multifunctional materials, wearable sensors, and drug delivery systems can monitor wounds and provide timely diagnosis and treatment, but there are still challenges to be addressed in their development and application.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Jin Zhou et al.
Summary: This study proposes a new strategy for cardiac repair using melanin nanoparticles/alginate hydrogels, which possess antioxidant properties and promote macrophage polarization. The experiments in an MI rat model demonstrate that the hydrogel has good antioxidant, anti-inflammatory, and proangiogenesis effects.
Article
Engineering, Biomedical
Qiankun Zeng et al.
Summary: A nanocomposite hydrogel XKP was developed for skin wound healing, featuring high elasticity and tunable water content to adapt to wound shape. The embedded PDA NPs act as photothermal transduction agents to trigger bacterial death, accelerating wound healing significantly by reducing inflammation and promoting vascular reconstruction.
BIOACTIVE MATERIALS
(2021)
Review
Engineering, Environmental
Mahmoud H. Abu Elella et al.
Summary: Xanthan gum, a naturally occurring microbial exopolysaccharide, has shown significant potential in various applications. To overcome its limitations, efforts have been made to modify xanthan gum through diverse approaches, aiming to enhance its physicochemical properties for drug delivery, tissue engineering, and environmental applications.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Gang Ge et al.
Article
Polymer Science
Andreia Alves et al.
Article
Chemistry, Multidisciplinary
Qian Pang et al.
Article
Multidisciplinary Sciences
Tengfei Liu et al.
NATURE COMMUNICATIONS
(2020)
Review
Food Science & Technology
Yiping Cao et al.
Article
Engineering, Biomedical
He Zhao et al.
Article
Chemistry, Multidisciplinary
Haibin Wu et al.
ACS CENTRAL SCIENCE
(2019)
Article
Chemistry, Multidisciplinary
Min Gong et al.
ADVANCED FUNCTIONAL MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Rong-Hui Deng et al.
Article
Chemistry, Applied
Xi Yang et al.
CARBOHYDRATE POLYMERS
(2019)
Article
Engineering, Biomedical
Qin Jiang et al.
Review
Multidisciplinary Sciences
Bryan K. Sun et al.
Review
Biochemistry & Molecular Biology
Michael Potente et al.
Review
Multidisciplinary Sciences
Geoffrey C. Gurtner et al.
