☆ 4.5 Review

Diacerein versus non-steroidal anti-inflammatory drugs in the treatment of knee osteoarthritis: a meta-analysis

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2023)

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Summary: This year's review summarizes key research highlights in osteoarthritis (OA) rehabilitation from April 1, 2021, to March 18, 2022. Studies were identified through electronic database searches and categorized into topics such as core OA rehabilitation treatments, adjunctive treatments, novel treatments or research methods, and translation of evidence into practice. Headline findings include the positive role of technology in remote delivery of core OA rehabilitation, the importance of combining educational interventions with exercise, controversy over the mechanisms of action of exercise, and the increasing research on blood flow restriction training. It is emphasized that future research should be large-scale and robust to address important remaining questions in OA rehabilitation.

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Summary: The GRADE methods are widely used in clinical practice guidelines to evaluate the quality of evidence and make recommendations. This essay summarized the use of GRADE methods in traditional, complementary, and integrative medicine clinical practice guidelines, highlighting some challenges.

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Review Clinical Neurology

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Summary: OA is a leading cause of disability among older adults worldwide, and the goal of treatment is to alleviate inflammatory pain and improve physical function. When selecting NSAIDs, factors such as patient age, comorbidities, polypharmacy, and benefit/risk balance need to be considered to reduce the risk of adverse events. The safety profiles of different NSAIDs are not straightforward, and a multidisciplinary approach is recommended to maximize therapy efficacy while minimizing untoward effects.

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Review Nutrition & Dietetics

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Review Immunology

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OSTEOARTHRITIS AND CARTILAGE (2010)

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Review Rheumatology

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Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling

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Article Medicine, General & Internal

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Role of interleukin-1 and tumor necrosis factor a in matrix degradation of human osteoarthritic cartilage

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ARTHRITIS AND RHEUMATISM (2005)

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Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis

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OSTEOARTHRITIS AND CARTILAGE (2004)

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Article Orthopedics

Diacerhein and rhein reduce the ICE-induced IL-1β and IL-18 activation in human osteoarthritic cartilage

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OSTEOARTHRITIS AND CARTILAGE (2000)

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