期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2023.1122364
关键词
pain; disability; epigenetic aging; hand grip strength; physical function
Chronic pain is a leading cause of disability and can accelerate biological aging and reduce physical function. Epigenetic clocks can estimate the aging process and predict health outcomes like physical function. Grip strength, a measure of muscle quality, is influenced by self-reported pain. This study explored the associations among chronic pain, grip strength, and epigenetic aging.
IntroductionChronic pain is one of the leading causes of disability that may accelerate biological aging and reduce physical function. Epigenetic clocks provide an estimate of how the system ages and can predict health outcomes such as physical function. Physical function declines may be attributed to decreases in muscle quality due to disuse that can be measured quickly and noninvasively using grip strength. The purpose of this study was to explore the associations among self-reported pain, grip strength, and epigenetic aging in those with chronic pain. MethodsParticipants (57.91 +/- 8.04 years) completed pain questionnaires, a blood draw and hand grip strength task. We used an epigenetic clock previously associated with knee pain (DNAmGrimAge), and used the subsequent difference of predicted epigenetic age from chronological age (DNAmGrimAge-Difference). ResultsExploratory pathway analyses revealed that pain intensity mediated the association between DNAmGrimAge-difference and handgrip strength in males only (beta = -0.1115; CI [-0.2929, -0.0008]) and pain interference mediated the association between DNAmGrimAge-difference and handgrip strength in males beta = -0.1401; CI [-0.3400, -0.0222]), and females (beta = -0.024; CI [-0.2918, -0.0020]). DiscussionChronic knee pain may accelerate epigenetic aging processes that may influence handgrip strength in older age adults. Chronic pain could be a symptom of the aging body thus contributing to declines in musculoskeletal function in later life.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据