期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2023.1152626
关键词
ginseng; cognition; Alzheimer's disease; apolipoprotein epsilon 4; memory
This study examines the association between ginseng intake and AD-specific cognition in older adults and the moderating effect of APOE4 status. The results suggest that ginseng intake (with high duration and midlife onset) has a beneficial effect on AD-specific cognitive decline, specifically in delayed episodic memory. Furthermore, APOE4 status moderates the association between ginseng intake and AD-specific cognitive decline.
Background: The probable association among ginseng intake, Alzheimer's disease (AD)-specific cognition, and apolipoprotein e4 (APOE4) remains poorly investigated. Hence, we examined the association between ginseng intake and AD-specific cognition in older adults under the moderating effect of APOE4 status. Methods: This study enrolled 160 adults aged 65-90years without dementia. All participants underwent comprehensive dietary and clinical assessments including ginseng intake, AD-related cognition (i.e., delayed episodic memory, as the earliest cognitive change in AD), and non-memory cognition for comparative purposes. Results: Ginseng intake was associated with higher delayed episodic memory, but not non-memory cognition, compared to no ginseng intake. The interaction between ginseng intake and APOE4 status had a significant effect on delayed episodic memory. Subgroup analyses showed that ginseng intake was associated with higher delayed episodic memory in the APOE4-negative but not the APOE4positive subgroup. The benefits of ginseng intake on delayed episodic memory were prominent in the high duration (=5 years) and midlife onset (< 65years) groups. Conclusion: Our study of older adults with no dementia suggests that ginseng intake (with high duration and midlife onset) had a beneficial effect on ADspecific cognitive decline, i.e., the delayed episodic memory. In addition, APOE4 status moderates the association between ginseng intake status and AD-specific cognitive decline.
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