期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2023.1117068
关键词
subjective cognitive decline (SCD); Parkinson's disease; cognitive impairment; objective cognitive function; mild cognitive impairment
Cognitive impairment in Parkinson's disease worsens prognosis and causes burdens for caregivers and economic consequences. Subjective cognitive decline (SCD) has been regarded as an at-risk state for mild cognitive impairment (MCI) and a prodromal stage for dementia in Alzheimer's disease (AD). However, there is a lack of consensus on the definition and evaluation of SCD in Parkinson's disease (PD). This review found an association between PD-SCD and objective cognitive function, suggesting the importance of establishing a guideline for defining and evaluating SCD in PD.
Cognitive impairment in patients with Parkinson's disease (PD) worsens the prognosis of PD and increases caregivers' burden and economic consequences. Recently, subjective cognitive decline (SCD), which refers to self-reported cognitive decline without detectable objective cognitive dysfunction, has been regarded as an at-risk state of mild cognitive impairment (MCI) and a prodromal stage for dementia in Alzheimer's disease (AD). However, studies on PD-SCD have thus far been scarce, and at present there is no consensus regarding the definition of SCD nor a gold standard as an evaluation tool. The present review aimed to look for an association between PD-SCD and objective cognitive function and found that PD with SCD occurred with brain metabolic changes, which were consistent with early aberrant pathological changes in PD. Moreover, PD patients with SCD were likely to progress to future cognitive impairment. It is necessary to establish a guideline for the definition and evaluation of SCD in PD. A larger sample size and more longitudinal investigations are needed to verify the predictive effectiveness of PD-SCD and to detect earlier subtle cognitive decline before MCI.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据