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Contributions of blood-brain barrier imaging to neurovascular unit pathophysiology of Alzheimer's disease and related dementias

FRONTIERS IN AGING NEUROSCIENCE (2023)

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Quantification of blood-brain barrier water exchange and permeability with multidelay diffusion-weighted pseudo-continuous arterial spin labeling

Xingfeng Shao et al.

Summary: This study presents a pulse sequence and mathematical models for quantification of blood-brain barrier water exchange and permeability. The MCDW-pCASL sequence allows visualization of intravascular/extravascular ASL signals across multiple PLDs. The three-compartment SPA model provides a comprehensive measurement of blood-brain barrier water dynamics from group-averaged data, and a simplified LRL method was proposed for individual k(w) quantification.

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Longitudinal changes in brain oxygen extraction fraction (OEF) in older adults: Relationship to markers of vascular and Alzheimer's pathology

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Summary: The longitudinal change in oxygen extraction fraction (OEF) in older adults is primarily associated with vascular pathology, but not with markers of Alzheimer's disease (AD) pathology.

ALZHEIMERS & DEMENTIA (2023)

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Spatiotemporal Dynamics of Cerebral Vascular Permeability in Type 2 Diabetes-Related Cerebral Microangiopathy

Ying-Chen Chen et al.

Summary: This study found that cerebral microangiopathy with increased blood-brain barrier leakage occurs early in patients with type 2 diabetes mellitus (T2DM), before the appearance of cerebral small vessel disease (CSVD) on MRI. The involvement of white matter and gray matter is different in T2DM-related CSVD, and there are distinct features and mechanisms compared to other CSVDs.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Immunology

Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration

Kazuhisa Ishida et al.

Summary: This study reveals the role of aquaporin-4 (AQP4) in the clearance of extracellular tau from the brain to cerebrospinal fluid and deep cervical lymph nodes, with the deletion of AQP4 exacerbating tau deposition and neurodegeneration. The findings identify a novel regulatory mechanism of glymphatic clearance in the central nervous system for extracellular tau, which may contribute to tau aggregation and neurodegeneration.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

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Article Clinical Neurology

APOE ε4 dose associates with increased brain iron and β-amyloid via blood-brain barrier dysfunction

Yuto Uchida et al.

Summary: The study aimed to examine the effect of APOE ε4 dose on BBB clearance function and its correlation with brain iron and beta-amyloid accumulation. The results showed that increased APOE ε4 dose was associated with decreased effective brain-waste clearance through the BBB.

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Choroid Plexus Volume and Permeability at Brain MRI within the Alzheimer Disease Clinical Spectrum

Jong Duck Choi et al.

Summary: MRI evaluation revealed that larger choroid plexus volume in patients with cognitive impairment is associated with greater severity of cognitive impairment, with larger volume being linked to poorer memory, executive function, and global cognition.

RADIOLOGY (2022)

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Quantitative Water Permeability Mapping of Blood-Brain-Barrier Dysfunction in Aging

Jeremy N. Ford et al.

Summary: Blood-brain-barrier (BBB) dysfunction is a key feature of aging and aging-related disorders. A study found that BBB water exchange rate (k(W)) differs in various brain regions, with higher values in the cerebral cortex compared to cerebral white matter. This difference is also observed in cerebral blood flow (CBF). Age was found to be statistically significant in relation to k(W) and CBF. Furthermore, there were moderate negative correlations between k(W) and white matter hyperintensity (WMH) volume. This research provides insights into the relationship between BBB water exchange and aging, and has implications for potential BBB-targeted therapies for aging-related brain disorders.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Cerebral small vessel disease alters neurovascular unit regulation of microcirculation integrity involved in vascular cognitive impairment

Qin Yang et al.

Summary: Growing evidence suggests a significant association between altered neurovascular unit functioning and the pathophysiology of vascular cognitive impairment (VCI) caused by cerebral small vessel disease (CSVD). NVU dysregulation may lead to the entry of pathogens from the blood into the cerebral parenchyma by altering the blood-brain barrier (BBB), resulting in VCI. Additionally, the coupling of neural activity with cerebral blood flow and the clearance of metabolic byproducts may also be affected by NVU dysregulation.

NEUROBIOLOGY OF DISEASE (2022)

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Neel H. Mehta et al.

Summary: Cerebrospinal fluid (CSF) is a key protective mechanism of the central nervous system (CNS), playing roles in physical cushioning, nutrient delivery, and protein clearance. CSF volume and flow dynamics are crucial for regulating intracranial pressure and diagnosing disorders. CSF's ability to clear normal and pathological proteins implicates its production, circulation, and composition in neuropathologies. Neuroimaging techniques have been developed to study CSF flow and its relationship to anatomy and clinical conditions. Understanding CSF flow has implications for pathophysiology, new biomarkers, and treatments of neurological diseases.

NEUROBIOLOGY OF DISEASE (2022)

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Quantitative susceptibility mapping as an imaging biomarker for Alzheimer's disease: The expectations and limitations

Yuto Uchida et al.

Summary: This review summarizes the latest advances in the diagnosis and pathological mechanisms of Alzheimer's disease, including the closer association of tau pathology rather than beta-amyloid pathology with the onset and progression of Alzheimer's symptoms, as well as the pathomechanism of altered iron metabolism interacting with abnormal proteins related to AD pathology. The study also investigates the association of cerebral susceptibility values with other pathological biomarkers for AD.

FRONTIERS IN NEUROSCIENCE (2022)

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Associations of quantitative susceptibility mapping with Alzheimer's disease clinical and imaging markers

Petrice M. Cogswell et al.

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NEUROIMAGE (2021)

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Evaluation of Cerebral Blood Flow Measured by 3D PCASL as Biomarker of Vascular Cognitive Impairment and Dementia (VCID) in a Cohort of Elderly Latinx Subjects at Risk of Small Vessel Disease

Kay Jann et al.

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FRONTIERS IN NEUROSCIENCE (2021)

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Water exchange rate across the blood-brain barrier is associated with CSF amyloid-β 42 in healthy older adults

Brian T. Gold et al.

Summary: The water exchange rate across the blood-brain barrier (BBB), estimated with MRI, was positively associated with CSF amyloid beta (A beta)42 concentration levels in multiple brain regions, but only moderately associated with neuropsychological performance. This suggests that the water exchange rate may be a promising indicator of BBB A beta clearance functions.

ALZHEIMERS & DEMENTIA (2021)

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Article Clinical Neurology

Increase of blood-brain barrier leakage is related to cognitive decline in vascular mild cognitive impairment

Man Li et al.

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Sources of systematic error in DCE-MRI estimation of low-level blood-brain barrier leakage

Cameron Manning et al.

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MAGNETIC RESONANCE IN MEDICINE (2021)

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Magnetic Resonance Imaging of Blood-Brain Barrier permeability in Dementia

Audrey Chagnot et al.

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Relationship Between Amyloid-β Deposition and Blood-Brain Barrier Dysfunction in Alzheimer's Disease

Dong Wang et al.

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FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed

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APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline

Axel Montagne et al.

NATURE (2020)

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Restricted Effect of Cerebral Microbleeds on Regional Magnetic Susceptibility

Amir Fazlollahi et al.

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Dengrong Jiang et al.

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Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment

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Higher blood-brain barrier permeability is associated with higher white matter hyperintensities burden

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Recombinant Tissue Plasminogen Activator Increases Blood-Brain Barrier Disruption in Acute Ischemic Stroke: An MR Imaging Permeability Study

A. Kassner et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2009)

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Article Clinical Neurology

Lacunar Stroke Is Associated with Diffuse Blood-Brain Barrier Dysfunction

Joanna M. Wardlaw et al.

ANNALS OF NEUROLOGY (2009)

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Review Biochemistry & Molecular Biology

The blood-brain barrier in brain homeostasis and neurological diseases

Nicolas Weiss et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2009)

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Article Radiology, Nuclear Medicine & Medical Imaging

Tumour enhancing fraction (EnF) in glioma: relationship to tumour grade

Samantha J. Mills et al.

EUROPEAN RADIOLOGY (2009)

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Article Endocrinology & Metabolism

Characterizing the origin of the arterial spin labelling signal in MRI using a multiecho acquisition approach

Jack A. Wells et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2009)

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Article Radiology, Nuclear Medicine & Medical Imaging

Quantitative permeability magnetic resonance imaging in acute ischemic stroke: how long do we need to scan?

Logi Vidarsson et al.

MAGNETIC RESONANCE IMAGING (2009)

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Review Geriatrics & Gerontology

Blood-brain barrier: Ageing and microvascular disease-systematic review and meta-analysis

Andrew J. Farrall et al.

NEUROBIOLOGY OF AGING (2009)

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Review Clinical Neurology

Vascular risk factors and dementia How to move forward?

Anand Viswanathan et al.

NEUROLOGY (2009)

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Article Clinical Neurology

Blood-brain barrier permeability in Alzheimer's disease: a case-control MRI study

John M. Starr et al.

PSYCHIATRY RESEARCH-NEUROIMAGING (2009)

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Review Immunology

The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction

Britta Engelhardt et al.

SEMINARS IN IMMUNOPATHOLOGY (2009)

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Article Radiology, Nuclear Medicine & Medical Imaging

Quantitative evaluation of oxygenation in venous vessels using T2-Relaxation-Under-Spin-Tagging MRI

Hanzhang Lu et al.

MAGNETIC RESONANCE IN MEDICINE (2008)

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Article Clinical Neurology

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

R. O. Carare et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2008)

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Article Clinical Neurology

Changes in background blood-brain barrier integrity between lacunar and cortical ischemic stroke subtypes

Joanna M. Wardlaw et al.

STROKE (2008)

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Article Radiology, Nuclear Medicine & Medical Imaging

Quantification of physiological and hemodynamic indices using T1 dynamic contrast-enhanced MRI in intracranial mass lesions

Anup Singh et al.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2007)

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Article Radiology, Nuclear Medicine & Medical Imaging

Correlation of relative permeability and relative cerebral blood volume in high-grade cerebral neoplasms

James M. Provenzale et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2006)

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Article Radiology, Nuclear Medicine & Medical Imaging

Comparative study of the physicochemical properties of six clinical low molecular weight gadolinium contrast agents

Sophie Laurent et al.

CONTRAST MEDIA & MOLECULAR IMAGING (2006)

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Article Neurosciences

Modeling the hemodynamic response to brain activation

RB Buxton et al.

NEUROIMAGE (2004)

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Article Radiology, Nuclear Medicine & Medical Imaging

Coomparative study of methods for determining vascular permeability and blood volume in human gliomas

JU Harrer et al.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2004)

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Review Neurosciences

The blood-brain barrier: an overview - Structure, regulation, and clinical implications

P Ballabh et al.

NEUROBIOLOGY OF DISEASE (2004)

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Article Cell Biology

Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice

T Nitta et al.

JOURNAL OF CELL BIOLOGY (2003)

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Article Clinical Neurology

Increased blood-brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging

JM Starr et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2003)

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