The development of functional connectivity within the dorsal striatum from early childhood to adulthood

Dorsal striatum, principally comprising of caudate and putamen, is well-known to support motor function but also various higher-order cognitive functions. This is enabled by developing short- and long-range connections to distributed cortical regions throughout the life span, but few studies have examined developmental changes from young children to adults in the same cohort. Here we investigated the development of dorsal-striatal network in a large (n = 476), single-site sample of healthy subjects 3-42 years of age in three groups (children, adolescence, adults). The results showed that the connectivity within the striatum and to sensorimotor regions was established at an early stage of life and remained strong in adolescence, supporting that sensory-seeking behaviours and habit formation are important learning mechanisms during the developmental periods. This connectivity diminished with age, as many behaviours become more efficient and automated. Adolescence demonstrated a remarkable transition phase where the connectivity to dorsolateral prefrontal cortex emerged but connectivity to the dorsomedial prefrontal and posterior brain, which belong to the ventral attentional and default mode networks, was only seen in adults. This prolonged maturation in between-network integration may explain the behavioural characteristics of adolescents in that they exhibit elaborated cognitive performance but also demonstrate high risk-taking behaviours.

Automated summary

This study investigated the developmental changes in the dorsal striatal network from childhood to adulthood. The results showed that connectivity within the striatum and to sensorimotor regions was established early in life and remained strong during adolescence. However, this connectivity diminished with age as behaviors became more efficient and automated. Adolescence was characterized by a transition phase where connectivity to the dorsolateral prefrontal cortex emerged, but connectivity to other brain regions only appeared in adults. This prolonged maturation in between-network integration may explain the cognitive and risk-taking behaviors observed in adolescence.