期刊
KOREAN JOURNAL OF CHEMICAL ENGINEERING
卷 33, 期 8, 页码 2253-2267出版社
KOREAN INSTITUTE CHEMICAL ENGINEERS
DOI: 10.1007/s11814-016-0114-6
关键词
Toxic Chemicals; Total Process System; Micro-total Envelopment System; Separator; Extraction Unit; Tube in Tube System; Dual Channel Microreactor; Silicon Nanowire Reactor; Diaze Compound; Azide; Carbon Monoxide; Ozone; Chloro Methyl Methyl Ether
资金
- National Research Foundation (NRF) of Korea grant - Korean government [NRF-2008-0061983, NRF-2014M1A8A1074940]
- National Research Foundation of Korea [2014M1A8A1074940] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The development and enlargement of toxic and hazardous chemicals are severely limited by health and safety concerns. We summarize studies on fully integrated micro-chemical systems and total processes to reduce accidental exposure to various regents that are toxic, explosive, or carcinogenic, which significantly improved the safety of work involving risky compounds. This review covers the leak-free continuous-flow processes of hazardous chemicals in fully integrated microfluidic systems, specially denoted as micro-total envelope systems (mu-TESs), that are conducting a serial process of the generation of hazardous reagents, in-situ purification and separation, subsequent reaction, and product isolation with improved efficiencies. These attempts suggest safe and efficient tools and processes of useful but hazardous chemicals for researchers and manufacturing workers in the field of pharmaceutic discovery, natural products, biology as well as materials synthesis.
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