Ketone bodies promote stroke recovery via GAT-1-dependent cortical network remodeling

Article Biochemistry & Molecular Biology

Inhibition of HDAC3 and ATXN3 by miR-25 prevents neuronal loss and ameliorates neurological recovery in cerebral stroke experimental rats

Xiaomei Zhou et al.

Summary: This study investigated the role of miR-25 in regulating HDAC3-induced neuronal injury and identified miR-25 as an important predictive biomarker for acute ischemic stroke.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2022)

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Review Biochemistry & Molecular Biology

Overview of Acute Ischemic Stroke Evaluation and Management

Tasneem F. Hasan et al.

Summary: Stroke is a major cause of death and disability globally. Rapid treatment to restore cerebral blood flow and salvage ischemic brain tissue is crucial in acute ischemic stroke management.

BIOMEDICINES (2021)

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Article Clinical Neurology

Common molecular mechanisms of SLC6A1 variant-mediated neurodevelopmental disorders in astrocytes and neurons

Felicia Mermer et al.

Summary: SLC6A1 gene variants are associated with a spectrum of epilepsy syndromes and neurodevelopmental disorders. The major disease mechanism appears to be impaired transporter protein trafficking and surface expression, leading to reduced GABA uptake. Abnormal subcellular localization, endoplasmic reticulum retention, and decreased cell surface expression of variant GAT-1 proteins are common findings, suggesting that boosting transporter function could be beneficial for therapeutic development.

BRAIN (2021)

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Editorial Material Biochemistry & Molecular Biology

Neurobiology: Resetting the axon's batteries

Jeffery L. Twiss et al.

Summary: Neuronal injury can lead to mitochondrial damage, affecting energy production and Ca2+ storage while increasing reactive oxygen species. A new study has identified a mechanism to promote neuroprotection and axon regeneration by facilitating axonal transport of mitochondria and replacing damaged ones with functional ones.

CURRENT BIOLOGY (2021)

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Review Neurosciences

Ketone Bodies in the Brain Beyond Fuel Metabolism: From Excitability to Gene Expression and Cell Signaling

Dario Garcia-Rodriguez et al.

Summary: Ketone bodies are metabolites that can replace glucose as the main fuel of the brain in glucose scarcity situations. Apart from being an alternative fuel, they also have effects on neuronal physiology and gene expression, regulating neuronal excitability and responding to oxidative stress. In addition, they can act as signaling molecules in brain cells.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

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Review Cell Biology

Axonal remodeling of the corticospinal tract during neurological recovery after stroke

Zhongwu Liu et al.

Summary: This review examines the effects of CST axonal damage, the role of CST axonal integrity and remodeling in neurological recovery, and therapeutic approaches aimed at enhancing CST axonal remodeling after stroke. The insights from both preclinical and clinical studies may lead to the development of more targeted therapies to promote axonal rewiring for corticospinal innervation.

NEURAL REGENERATION RESEARCH (2021)

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Review Neurosciences

Encouraging an excitable brain state: mechanisms of brain repair in stroke

Mary T. Joy et al.

Summary: Stroke induces a plastic state in the brain, leading to the formation of new axons, synapses, and remapping of sensory-motor functions, facilitating motor recovery. The period of increased plasticity after stroke is driven by molecular systems related to learning and memory, resulting in changes in neuronal excitability. Understanding the mechanisms behind these changes is crucial for promoting functional recovery after stroke.

NATURE REVIEWS NEUROSCIENCE (2021)

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Article Medicine, Research & Experimental

Environmental enrichment implies GAT-1 as a potential therapeutic target for stroke recovery

Yuhui Lin et al.

Summary: The study revealed that environmental enrichment promotes stroke recovery by regulating GAT-1 to enhance network excitability. GAT-1 plays a crucial role in the network plasticity and functional recovery from stroke induced by environmental enrichment.

THERANOSTICS (2021)

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Article Biochemistry & Molecular Biology

HDAC2 (Histone deacetylase 2): A critical factor in environmental enrichment-mediated stroke recovery

Yu-Hui Lin et al.

JOURNAL OF NEUROCHEMISTRY (2020)

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Article Neurosciences

Neurochemical balance and inhibition at the subacute stage after stroke

John Cirillo et al.

JOURNAL OF NEUROPHYSIOLOGY (2020)

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Review Nutrition & Dietetics

Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States

Arkadiusz Dabek et al.

NUTRIENTS (2020)

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Review Biotechnology & Applied Microbiology

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Stephen C. Cunnane et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Article Clinical Neurology

β-Oscillations Reflect Recovery of the Paretic Upper Limb in Subacute Stroke

Chih-Wei Tang et al.

NEUROREHABILITATION AND NEURAL REPAIR (2020)

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Article Biochemistry & Molecular Biology

CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury

Mary T. Joy et al.

CELL (2019)

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Article Clinical Neurology

Dissociating nNOS (Neuronal NO Synthase)-CAPON (Carboxy-Terminal Postsynaptic Density-95/Discs Large/Zona Occludens-1 Ligand of nNOS) Interaction Promotes Functional Recovery After Stroke via Enhanced Structural Neuroplasticity

Huan-Yu Ni et al.

STROKE (2019)

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Article Biochemistry & Molecular Biology

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet

Chia-Wei Cheng et al.

CELL (2019)

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Article Oncology

Dissociation of nNOS from PSD-95 promotes functional recovery after cerebral ischaemia in mice through reducing excessive tonic GABA release from reactive astrocytes

Yu-Hui Lin et al.

JOURNAL OF PATHOLOGY (2018)

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Article Clinical Neurology

Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man

Rhiannon S. Morris et al.

BRAIN (2018)

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Review Neurosciences

Do ketone bodies mediate the anti-seizure effects of the ketogenic diet?

Timothy A. Simeone et al.

NEUROPHARMACOLOGY (2018)

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Article Clinical Neurology

Imaging the Effects of beta-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism

Paolo Bazzigaluppi et al.

STROKE (2018)

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Article Neurosciences

Opening a New Time Window for Treatment of Stroke by Targeting HDAC2

Yu-Hui Lin et al.

JOURNAL OF NEUROSCIENCE (2017)

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Article Clinical Neurology

Disability Trajectories Before and After Stroke and Myocardial Infarction The Cardiovascular Health Study

Mandip S. Dhamoon et al.

JAMA NEUROLOGY (2017)

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Review Cell Biology

Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics

Patrycja Puchalska et al.

CELL METABOLISM (2017)

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Article Clinical Neurology

Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target

Takeshi Hiu et al.

BRAIN (2016)

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Effects of beta-hydroxybutyrate on brain vascular permeability in rats with traumatic brain injury

Nurcan Orhan et al.

BRAIN RESEARCH (2016)

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Article Biology

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

Sama F. Sleiman et al.

ELIFE (2016)

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Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits

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CELL (2015)

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Novel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical Treatments

Paul M. George et al.

NEURON (2015)

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Article Multidisciplinary Sciences

Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity

Leonid Savtchenko et al.

NATURE COMMUNICATIONS (2015)

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Review Endocrinology & Metabolism

β-hydroxybutyrate: Much more than a metabolite

John C. Newman et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2014)

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Review Clinical Neurology

Modulation of brain plasticity in stroke: a novel model for neurorehabilitation

Giovanni Di Pino et al.

NATURE REVIEWS NEUROLOGY (2014)

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Article Multidisciplinary Sciences

Optogenetic neuronal stimulation promotes functional recovery after stroke

Michelle Y. Cheng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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NEURONAL REPAIR Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke

A. S. Wahl et al.

SCIENCE (2014)

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Article Multidisciplinary Sciences

The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages

Mahbubur Rahman et al.

NATURE COMMUNICATIONS (2014)

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Review Clinical Neurology

The interaction between training and plasticity in the poststroke brain

Steven R. Zeiler et al.

CURRENT OPINION IN NEUROLOGY (2013)

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Molecular logic of neocortical projection neuron specification, development and diversity

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Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

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An epigenetic blockade of cognitive functions in the neurodegenerating brain

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Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity

Raluca Reitmeir et al.

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Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke

Andrew N. Clarkson et al.

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Plasticity during stroke recovery: from synapse to behaviour

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GAT-1 regulates both tonic and phasic GABAA receptor-mediated inhibition in the cerebral cortex

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Recovery of learning and memory is associated with chromatin remodelling

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On the human sensorimotor-cortex beta rhythm: Sources and modeling

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Growth-associated gene expression after stroke: Evidence for a growth-promoting region in peri-infarct cortex

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EXPERIMENTAL NEUROLOGY (2005)

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Variations on an inhibitory theme:: Phasic and tonic activation of GABAA receptors

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GABA transporter-1 (GAT1)-Deficient mice:: Differential tonic activation of GABAA versus GABAB receptors in the hippocampus

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Ketone bodies promote stroke recovery via GAT-1-dependent cortical network remodeling

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