4.8 Article

Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Cell-Intrinsic Mechanisms of Drug Tolerance to Systemic Therapies in Cancer

Camille Leonce et al.

Summary: In patients with metastatic cancer, complete tumor response to systemic therapies is rare due to early molecular adaptation in cancer cells, resulting in residual lesions. Evidence suggests that drug-tolerant persister cells, characterized by reduced drug sensitivity and cell proliferation, play a role in maintaining residual disease and may contribute to resistant phenotypes.

MOLECULAR CANCER RESEARCH (2022)

Article Multidisciplinary Sciences

Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma

Lorey K. Smith et al.

Summary: This study investigates the impact of BRAF inhibition on metabolism in melanoma cells. Through a genome-wide RNA interference screen and gene expression profiling, the researchers found that BRAF inhibition can regulate metabolism through selective mRNA transport and translation. They discovered that U2AF homology motif kinase 1 (UHMK1) associates with mRNAs encoding metabolism proteins and controls their transport and translation during adaptation to BRAF-targeted therapy. Inactivation of UHMK1 leads to cell death and delays resistance to BRAF and MEK combination therapy.

NATURE COMMUNICATIONS (2022)

Article Biochemistry & Molecular Biology

Optogenetic actuator - ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics

Coralie Dessauges et al.

Summary: Combining single-cell measurements of ERK activity dynamics with perturbations provides insights into the MAPK network topology. The study found that the MAPK network is robust against most node perturbations and that the ERK-RAF and ERK-RSK2-SOS negative feedback operate simultaneously to regulate ERK dynamics. Additionally, bypassing the RSK2-mediated feedback enhances the sensitivity of ERK dynamics to perturbations and targeting this feedback improves the efficiency of MAPK inhibitors in a cancer signaling model.

MOLECULAR SYSTEMS BIOLOGY (2022)

Article Cell Biology

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

Bas Ponsioen et al.

Summary: The study illustrates how EGFR activity enhances signal transduction efficiency in KRAS or BRAF mutant MAPK pathways, revealing a potential mechanism for using EGFR inhibitors in colorectal cancer with KRAS and BRAF mutations.

NATURE CELL BIOLOGY (2021)

Article Multidisciplinary Sciences

Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling

Chen Yang et al.

Summary: Despite the increasing number of effective anti-cancer therapies, drug resistance remains a major challenge in successful cancer treatment. This study tracks the responses of single melanoma cells to BRAF inhibitors and identifies a subset of cells that quickly evade drug action through non-genetic mechanisms, leading to DNA damage.

NATURE COMMUNICATIONS (2021)

Review Oncology

Mechanisms of Resistance to KRASG12C-Targeted Therapy

Neal S. Akhave et al.

Summary: KRAS mutations drive cancer growth, but the development of resistance to targeted therapies remains a challenge. Understanding the mechanisms of resistance and developing combination strategies are crucial for long-term disease control.

CANCER DISCOVERY (2021)

Review Biochemistry & Molecular Biology

Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment

D. Lucas Kerr et al.

Summary: SHP2, a nonreceptor protein tyrosine phosphatase, was considered 'undruggable' for decades, but has now become a potential target with the advent of allosteric inhibitors. These inhibitors show promise in preclinical cancer models and may also have immunomodulatory effects in certain tumor microenvironment cells. Clinical evaluation of the first generation of allosteric inhibitors will determine their safety, tolerability management, and antitumor efficacy for future applications.

CURRENT OPINION IN CHEMICAL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Targeting Son of Sevenless 1: The pacemaker of KRAS

Dirk Kessler et al.

Summary: Son of Sevenless (SOS) is a guanine nucleotide exchange factor that plays a key role in activating the important cell signaling switch KRAS. Inhibition of SOS1 with potent inhibitors like BI-3406 has shown promising antiproliferative effects against various oncogenic KRAS mutants. The first SOS1 inhibitor has entered clinical trials for KRAS-mutated cancers, highlighting the potential therapeutic significance of targeting this pathway.

CURRENT OPINION IN CHEMICAL BIOLOGY (2021)

Article Cell Biology

Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival

Paolo Armando Gagliardi et al.

Summary: Cell death events are essential for eliminating old or damaged cells, but how apoptotic events are organized spatially and temporally to maintain epithelial homeostasis is still unclear. Research has shown that waves of ERK/Akt activity pulses originating from apoptotic cells can act as spatial survival signals, protecting nearby cells from apoptosis for a period of 3-4 hours. At the population level, these waves help maintain epithelial homeostasis in response to environmental insults.

DEVELOPMENTAL CELL (2021)

Article Biochemistry & Molecular Biology

Targeting mTOR signaling overcomes acquired resistance to combined BRAF and MEK inhibition in BRAF-mutant melanoma

Beike Wang et al.

Summary: The study focuses on utilizing a combination of BRAF and MEK inhibitors to target the MAPK pathway in treating melanoma, with findings showing the crucial role of the mTORC1 signaling pathway in mediating drug resistance. Interestingly, some resistant melanoma cells are sensitive to mTORC1 inhibition, indicating the importance of mTOR activation in melanoma resistance to MAPK inhibitors.

ONCOGENE (2021)

Letter Dermatology

E2F1/IGF-1R Loop Contributes to BRAF Inhibitor Resistance in Melanoma

Xiao Liu et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

Article Biochemistry & Molecular Biology

Kinetics of receptor tyrosine kinase activation define ERK signaling dynamics

Anatoly Kiyatkin et al.

SCIENCE SIGNALING (2020)

Review Oncology

Non-genetic mechanisms of therapeutic resistance in cancer

Jean-Christophe Marine et al.

NATURE REVIEWS CANCER (2020)

Review Pharmacology & Pharmacy

ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway

Andrew M. Kidger et al.

PHARMACOLOGY & THERAPEUTICS (2018)

Article Medicine, Research & Experimental

VEGF blockade enhances the antitumor effect of BRAFV600E inhibition

Valentina Comunanza et al.

EMBO MOLECULAR MEDICINE (2017)

Article Multidisciplinary Sciences

Rare cell variability and drug- induced reprogramming as a mode of cancer drug resistance

Sydney M. Shaffer et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

Genomic Classification of Cutaneous Melanoma

Rehan Akbani et al.

Article Biochemistry & Molecular Biology

High-Sensitivity Measurements of Multiple Kinase Activities in Live Single Cells

Sergi Regot et al.

Article Biochemistry & Molecular Biology

Spatiotemporal Control of Fibroblast Growth Factor Receptor Signals by Blue Light

Nury Kim et al.

CHEMISTRY & BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanoma

Amanda Lassen et al.

MOLECULAR CANCER (2014)

Article Medicine, General & Internal

Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma

G. V. Long et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Oncology

The Cell-Cycle Regulator CDK4: An Emerging Therapeutic Target in Melanoma

Karen E. Sheppard et al.

CLINICAL CANCER RESEARCH (2013)

Article Medicine, Research & Experimental

Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3

Ethan V. Abel et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Oncology

Receptor tyrosine kinases and their activation in melanoma

David J. Easty et al.

PIGMENT CELL & MELANOMA RESEARCH (2011)

Article Multidisciplinary Sciences

Melanomas acquire resistance toB-RAF(V600E) inhibition by RTK or N-RAS upregulation

Ramin Nazarian et al.

NATURE (2010)

Review Oncology

Oncogene addiction

I. Bernard Weinstein et al.

CANCER RESEARCH (2008)

Article Biochemistry & Molecular Biology

Visualizing spatiotemporal dynamics of multicellular cell-cycle progression

Asako Sakaue-Sawano et al.