Ensembles code for associative learning in the primate lateral prefrontal cortex

The lateral prefrontal cortex (LPFC) of primates is thought to play a role in associative learning. However, it remains unclear how LPFC neuronal ensembles dynamically encode and store memories for arbitrary stimulus-response associations. We recorded the activity of neurons in LPFC of two macaques during an associative learning task using multielectrode arrays. During task trials, the color of a symbolic cue indicated the location of one of two possible targets for a saccade. During a trial block, multiple randomly chosen associations were learned by the subjects. A state-space analysis indicated that LPFC neuronal ensembles rapidly learn new stimulus-response associations mirroring the animals' learning. Multiple associations acquired during training are stored in a neuronal subspace and can be retrieved hours after learning. Finally, knowledge of old associations facilitates learning new, similar associations. These results indicate that neuronal ensembles in the primate LPFC provide a flexible and dynamic substrate for associative learning.

Automated summary

The neuronal ensembles in the lateral prefrontal cortex of non-human primates can dynamically encode and store arbitrary stimulus-response associations. These ensembles rapidly learn new associations and can retrieve multiple previously learned associations from a neuronal subspace. Additionally, knowledge of old associations facilitates the learning of new, similar associations.