相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。The hallmarks of cancer metabolism: Still emerging
Natalya N. Pavlova et al.
CELL METABOLISM (2022)
Membrane-Initiated Estrogen, Androgen, and Progesterone Receptor Signaling in Health and Disease
Franck Mauvais-Jarvis et al.
ENDOCRINE REVIEWS (2022)
DOC2b Enhances β-Cell Function via a Novel Tyrosine Phosphorylation-Dependent Mechanism
Diti Chatterjee Bhowmick et al.
DIABETES (2022)
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10)
Makoto Fushimi et al.
ACS MEDICINAL CHEMISTRY LETTERS (2021)
Emerging Roles of Small GTPases in Islet β-Cell Function
Rajakrishnan Veluthakal et al.
CELLS (2021)
Lactate activation of α-cell KATP channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca2+ entry
Karolina E. Zaborska et al.
MOLECULAR METABOLISM (2020)
Intracrine Testosterone Activation in Human Pancreatic β-Cells Stimulates Insulin Secretion
Weiwei Xu et al.
DIABETES (2020)
Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial
Gary Wittert et al.
Lancet Diabetes & Endocrinology (2020)
Testosterone Therapy in Men With Hypogonadism Prevents Progression From Prediabetes to Type 2 Diabetes: Eight-Year Data From a Registry Study
Aksam Yassin et al.
DIABETES CARE (2019)
Emerging role of testosterone in pancreatic β cell function and insulin secretion
Weiwei Xu et al.
JOURNAL OF ENDOCRINOLOGY (2019)
Illuminating G-Protein-Coupling Selectivity of GPCRs
Asuka Inoue et al.
CELL (2019)
Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression
Christoph Hafemeister et al.
GENOME BIOLOGY (2019)
cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes
Timothy B. Johnstone et al.
MOLECULAR PHARMACOLOGY (2018)
Targeting GLP-1 receptor trafficking to improve agonist efficacy
Ben Jones et al.
NATURE COMMUNICATIONS (2018)
Clustering trees: a visualization for evaluating clusterings at multiple resolutions
Luke Zappia et al.
GIGASCIENCE (2018)
Localization of mTORC2 activity inside cells
Michael Ebner et al.
JOURNAL OF CELL BIOLOGY (2017)
Androgen receptor-deficient islet β-cells exhibit alteration in genetic markers of insulin secretion and inflammation. A transcriptome analysis in the male mouse
Weiwei Xu et al.
JOURNAL OF DIABETES AND ITS COMPLICATIONS (2017)
Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma
Angelica Benavides-Serrato et al.
PLOS ONE (2017)
Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
Manuel Blandino-Rosano et al.
NATURE COMMUNICATIONS (2017)
Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not -Cell Mass
Emilyn U. Alejandro et al.
DIABETES (2017)
The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice
Adam Chambers et al.
CELL METABOLISM (2017)
Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male
Guadalupe Navarro et al.
CELL METABOLISM (2016)
Soluble adenylyl cyclase is essential for proper lysosomal acidification
Nawreen Rahman et al.
JOURNAL OF GENERAL PHYSIOLOGY (2016)
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase
Lavoisier Ramos-Espiritu et al.
NATURE CHEMICAL BIOLOGY (2016)
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
Maxim V. Kuleshov et al.
NUCLEIC ACIDS RESEARCH (2016)
Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone
Daniel Oropeza et al.
DIABETES (2015)
The Role of Androgens in Metabolism, Obesity, and Diabetes in Males and Females
Guadalupe Navarro et al.
OBESITY (2015)
ADCY5 Couples Glucose to Insulin Secretion in Human Islets
David J. Hodson et al.
DIABETES (2014)
Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake in Skeletal Muscle
Masaaki Sato et al.
DIABETES (2014)
Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation
Jessica M. Olsen et al.
JOURNAL OF CELL BIOLOGY (2014)
Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis
Nikoleta G. Tsvetanova et al.
NATURE CHEMICAL BIOLOGY (2014)
Adverse health effects of testosterone deficiency (TD) in men
Abdulmaged M. Traish
STEROIDS (2014)
Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic β-cells
Ramya S. Kuna et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)
STAR: ultrafast universal RNA-seq aligner
Alexander Dobin et al.
BIOINFORMATICS (2013)
High-Throughput Tyrosine Kinase Activity Profiling Identifies FAK as a Candidate Therapeutic Target in Ewing Sarcoma
Brian D. Crompton et al.
CANCER RESEARCH (2013)
CO2/HCO3-- and Calcium-regulated Soluble Adenylyl Cyclase as a Physiological ATP Sensor
Jonathan H. Zippin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Testosterone: a metabolic hormone in health and disease
Daniel M. Kelly et al.
JOURNAL OF ENDOCRINOLOGY (2013)
Mechanically Activated Fyn Utilizes mTORC2 to Regulate RhoA and Adipogenesis in Mesenchymal Stem Cells
William R. Thompson et al.
STEM CELLS (2013)
The Cortical Acto-Myosin Network: From Diffusion Barrier to Functional Gateway in the Transport of Neurosecretory Vesicles to the Plasma Membrane
Andreas Papadopulos et al.
Frontiers in Endocrinology (2013)
Pharmacological Distinction between Soluble and Transmembrane Adenylyl Cyclases
Jacob L. Bitterman et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells
Michael A. Kalwat et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2013)
Multivesicular exocytosis in rat pancreatic beta cells
M. B. Hoppa et al.
DIABETOLOGIA (2012)
Novel Mechanistic Link between Focal Adhesion Remodeling and Glucose-stimulated Insulin Secretion
Dieter Rondas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
A Small Novel A-Kinase Anchoring Protein (AKAP) That Localizes Specifically Protein Kinase A-Regulatory Subunit I (PKA-RI) to the Plasma Membrane
Pepijn P. Burgers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Gelsolin Associates with the N Terminus of Syntaxin 4 to Regulate Insulin Granule Exocytosis
Michael A. Kalwat et al.
MOLECULAR ENDOCRINOLOGY (2012)
Stimulus-induced S-Nitrosylation of Syntaxin 4 Impacts Insulin Granule Exocytosis
Dean A. Wiseman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes
Joseph P. Tiano et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
A mTurquoise-Based cAMP Sensor for Both FLIM and Ratiometric Read-Out Has Improved Dynamic Range
Jeffrey B. Klarenbeek et al.
PLOS ONE (2011)
Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer
Matthew T. Burger et al.
ACS MEDICINAL CHEMISTRY LETTERS (2011)
mTORC2 Regulates Neutrophil Chemotaxis in a cAMP- and RhoA-Dependent Fashion
Lunhua Liu et al.
DEVELOPMENTAL CELL (2010)
Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis
Winifred P. S. Wong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design
Seungil Han et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins
Zhanxiang Wang et al.
JOURNAL OF CELL SCIENCE (2009)
Nonsteroidal Selective Androgen Receptor Modulators (SARMs): Dissociating the Anabolic and Androgenic Activities of the Androgen Receptor for Therapeutic Benefit
Michael L. Mohler et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Testosterone deficiency, insulin resistance and the metabolic syndrome
Michael Zitzmann
NATURE REVIEWS ENDOCRINOLOGY (2009)
S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart
FF-T Ch'en et al.
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
C. Florian Bentzinger et al.
CELL METABOLISM (2008)
The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
Adrian J. Folkes et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic β-cells
Matthew J. Merrins et al.
JOURNAL OF PHYSIOLOGY-LONDON (2008)
8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes
Matthias Eckhardt et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Cellular characterization of a novel focal adhesion kinase inhibitor
Jill K. Slack-Davis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Molecular details of cAMP generation in mammalian cells: A tale of two systems
Margarita Kamenetsky et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Glucose acutely decreases pH of secretory granules in mouse pancreatic islets - Mechanisms and influence on insulin secretion
Patrick Stiernet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Islet β cell failure in type 2 diabetes
Marc Prentki et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Regulation of pancreatic β-cell insulin secretion by actin cytoskeleton remodelling:: role of gelsolin and cooperation with the MAPK signalling pathway
A Tomas et al.
JOURNAL OF CELL SCIENCE (2006)
RIP-Cre revisited, evidence for impairments of pancreatic β-cell function
JY Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Syntaxin 4 facilitates biphasic glucose-stimulated insulin secretion from pancreatic beta-cells
BA Spurlin et al.
MOLECULAR ENDOCRINOLOGY (2006)
Regulation of CFTR channels by HCO3--sensitive soluble adenylyl cyclase in human airway epithelial cells
Y Wang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2005)
Bicarbonate-responsive soluble adenylyl cyclase defines a nuclear cAMP microdomain
JH Zippin et al.
JOURNAL OF CELL BIOLOGY (2004)
A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis
K De Gendt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker
A Taddei et al.
FEBS LETTERS (2004)
Seven-transmembrane receptors
KL Pierce et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Steroid-induced androgen receptor-oestradiol receptor β-Src complex triggers prostate cancer cell proliferation
A Migliaccio et al.
EMBO JOURNAL (2000)
Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion
HE Hohmeier et al.
DIABETES (2000)