☆ 4.7 Review

The versatile roles of testrapanins in cancer from intracellular signaling to cell-cell communication: cell membrane proteins without ligands

CELL AND BIOSCIENCE (2023)

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Article Biochemistry & Molecular Biology

Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network

Zihan Yang et al.

Summary: In this study, LH1 was found to promote the confined migration and metastasis of cancer cells by stabilizing SEPT2 and facilitating actin polymerization. These findings provide new insights into the migration and metastasis mechanisms of tumor cells.

MOLECULAR CANCER (2023)

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Article Oncology

Transcriptional regulation of NDUFA4L2 by NFIB induces sorafenib resistance by decreasing reactive oxygen species in hepatocellular carcinoma

Li Zhou et al.

Summary: The study reveals that NFIB promotes drug resistance in HCC cells by transcriptionally upregulating NDUFA4L2, which reduces the induction of reactive oxygen species. High expression of NFIB is associated with aggressive tumor characteristics and poor prognosis.

CANCER SCIENCE (2023)

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Review Biochemistry & Molecular Biology

TSPAN1, a novel tetraspanin member highly involved in carcinogenesis and chemoresistance

Yoelsis Garcia-Mayea et al.

Summary: This review summarizes the physiological mechanisms of TSPANs in cancer, with a focus on the role of TSPAN1 in regulating resistance to chemotherapy. It proposes a model of TSPAN1 action and discusses the potential of targeting TSPAN1 in anticancer therapeutic strategies.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2022)

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Article Cell Biology

EGFR signaling promotes nuclear translocation of plasma membrane protein TSPAN8 to enhance tumor progression via STAT3-mediated transcription

Xiaoqing Lu et al.

Summary: This study reveals the unconventional function of TSPAN8 and uncovers the molecular mechanisms underlying its nuclear translocation. It demonstrates the role of TSPAN8 in regulating transcription of cancer-promoting genes and identifies it as a potential therapeutic target for refractory cancers.

CELL RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

Chen Zhang et al.

Summary: Ferroptosis, an iron-dependent form of cell death, plays a crucial role in tumor suppression and has the potential to reverse cancer therapy resistance.

MOLECULAR CANCER (2022)

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Article Biochemistry & Molecular Biology

TSPAN6 is a suppressor of Ras-driven cancer

Patrick O. Humbert et al.

Summary: This study identifies TSPAN6 as a tumor suppressor receptor that controls the initiation and progression of RAS-driven epithelial cancer. TSPAN6 suppresses tumor growth and metastasis by blocking EGFR-induced RAS activation.

ONCOGENE (2022)

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Editorial Material Cell Biology

Tetraspanins in cell stemness and cancer initiation: markers or active players?

Felipe Vences-Catalan et al.

Summary: This article discusses the role of tetraspanins in marking stem cells and tumor initiating cells. Recent studies focusing on adipose development, intestinal crypt remodeling, and muscle stem cells reveal the active contribution of tetraspanins and their associated partners in determining cell fate.

TRENDS IN CELL BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

CD63 acts as a functional marker in maintaining hematopoietic stem cell quiescence through supporting TGFβ signaling in mice

Mengjia Hu et al.

Summary: The study identifies CD63 as a novel functional marker of HSCs in mice, showing that high CD63 expression is associated with more quiescent HSCs with robust self-renewal and myeloid differentiation abilities. CD63 deficiency leads to reduced HSC numbers, impaired quiescence, and increased sensitivity to irradiation and 5-fluorouracil treatment. Further investigations reveal that CD63 interacts with TGF beta receptors to sustain TGF beta signaling activity and regulate HSC quiescence.

CELL DEATH AND DIFFERENTIATION (2022)

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Article Oncology

Tetraspanin 7 promotes osteosarcoma cell invasion and metastasis by inducing EMT and activating the FAK-Src-Ras-ERK1/2 signaling pathway

Shijie Shao et al.

Summary: This study demonstrates that Tspan7 promotes osteosarcoma (OS) metastasis by interacting with beta 1 integrin and activating the FAK-Src-Ras-ERK1/2 pathway. Tspan7 is highly expressed in primary OS tumors and cell lines, and downregulation of Tspan7 suppresses OS growth, metastasis, and epithelial-mesenchymal transition (EMT). This study provides a potential therapeutic strategy for OS.

CANCER CELL INTERNATIONAL (2022)

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Article Oncology

Overexpression of Tetraspanin31 contributes to malignant potential and poor outcomes in gastric cancer

Yusuke Takashima et al.

Summary: The overexpression of TSPAN31 is significantly associated with tumor invasion and worse prognosis in gastric cancer (GC). TSPAN31 plays a role in promoting cell proliferation and epithelial-mesenchymal transition in GC cells. Knockdown of TSPAN31 improves chemosensitivity to cisplatin.

CANCER SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Migrasome biogenesis and functions

Shunbang Yu et al.

Summary: Migrasomes are newly discovered organelles produced by migrating cells, and their main functions include releasing signaling molecules, carrying damaged mitochondria, and lateral transfer of mRNA or proteins.

FEBS JOURNAL (2022)

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Review Pharmacology & Pharmacy

Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications

Ritama Paul et al.

Summary: Cancer stem cells (CSCs) play a crucial role in cancer progression, metastasis, relapse, and therapy resistance. They maintain their self-renewal capability and resist the tumor microenvironment and treatments through mechanisms such as cellular plasticity, senescence, and quiescence. Understanding these mechanisms is important for future therapeutic implications.

PHARMACOLOGY & THERAPEUTICS (2022)

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Article Cell Biology

Assembly of Tetraspanin-enriched macrodomains contains membrane damage to facilitate repair

Yuwei Huang et al.

Summary: The assembly of Tetraspanin-enriched macrodomains creates a physical barrier to contain membrane damage, facilitating membrane repair by restricting the spread of the damage and preventing membrane disintegration.

NATURE CELL BIOLOGY (2022)

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Article Oncology

TSPAN31 regulates the proliferation, migration, and apoptosis of gastric cancer cells through the METTL1/CCT2 pathway

Xiang Ma et al.

Summary: This study found that TSPAN31 was highly expressed in gastric cancer tissues and was associated with poor prognosis in patients with gastric cancer. TSPAN31 can regulate the proliferation, migration, and apoptosis of gastric cancer cells. This regulation may be achieved through co-expression with METTL1 and CCT2.

TRANSLATIONAL ONCOLOGY (2022)

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Article Microbiology

The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication

Lisa Lasswitz et al.

Summary: In this study, CD81 is identified as a host factor for the globally emerging chikungunya virus and related alphaviruses, promoting viral genome replication in human and mouse cells while being dispensable for virus entry. The cholesterol-binding ability of CD81 is crucial for its function as an alphavirus host factor, broadening our understanding of the alphavirus replication process by reprogramming cells into virus replication factories.

MBIO (2022)

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Article Oncology

AQP5 complements LGR5 to determine the fates of gastric cancer stem cells through regulating ULK1 ubiquitination

Rou Zhao et al.

Summary: This study identifies AQP5 as a specific surface marker for GC-CSCs and reveals its molecular mechanism in promoting tumorigenesis. The study also highlights the importance of targeting both AQP5 and LGR5 as a promising approach for the treatment of gastric cancer.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Tetraspanin-29 activates Notch signaling by interacting with ADAM10 to enhance its activity in colorectal cancer

Shijie Yuan et al.

Summary: The tetraspanin-29/ADAM10/Notch pathway plays an important role in colorectal cancer, with tetraspanin-29 regulating ADAM10 and Notch signaling.

BIOCHEMISTRY AND CELL BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Aberrant TIMP-1 overexpression in tumor-associated fibroblasts drives tumor progression through CD63 in lung adenocarcinoma

Paula Duch et al.

Summary: This study analyzed the expression of TIMP-1 and its cell surface receptor CD63 in lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC). The researchers found that TIMP-1 was aberrantly overexpressed in ADC-associated fibroblasts and promoted the growth and invasion of ADC cancer cells. The study suggests that the TIMP-1/CD63 interaction could be a potential therapeutic target in lung cancer.

MATRIX BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness

Jeremy Nigri et al.

Summary: In pancreatic ductal adenocarcinoma (PDAC), signaling from stromal cells through extracellular vesicles (EVs) is involved in metastatic progression. This study identified CD9 as a key component of EVs derived from cancer-associated stromal fibroblasts (CAFs), which mediate the cross-talk between tumor cells and the stroma. Blocking CD9 impaired the uptake of EVs into PDAC cells, and CD9(+) EVs induced MAPK pathway activation, cell migration, and EMT. Inhibiting CD9 or p38 MAPK signaling impaired EV-induced cell migration and EMT. Bioinformatic analysis showed that CD9 abundance is an independent prognostic marker for poor prognosis in PDAC patients.

SCIENCE SIGNALING (2022)

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Article Cell Biology

Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function

Vera-Marie E. Dunlock et al.

Summary: T cells rely on the phosphatase CD45 and its partner CD53 for optimal signaling and activation, with CD53 controlling CD45 function and stability on the cell membrane. Understanding the mechanisms of CD45 regulation and CD53-mediated T cell immunity is crucial for advancing our knowledge of immune responses.

CELL REPORTS (2022)

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Article Multidisciplinary Sciences

Tetraspanin CD82 restrains phagocyte migration but supports macrophage activation

Erin N. S. McGowan et al.

Summary: CD82 plays an important role in restraining excessive phagocyte migration and mediating their differentiation in response to stimulatory cues. Deficiency of CD82 can lead to impaired control of infection.

ISCIENCE (2022)

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Review Pharmacology & Pharmacy

Tetraspanin-enriched Microdomain Containing CD151, CD9, and TSPAN 8-Potential Mediators of Entry and Exit Mechanisms in Respiratory Viruses Including SARS-CoV-2

RamaRao Malla et al.

Summary: This article updates recent advances in structural proteins of SARS-CoV-2, their epitopes, and putative receptors, as well as their regulation by proteases associated with TEMs. It also furnishes recent updates on the role of CD151 in the pathophysiology of SARS-CoV-2, and the role of CD9 and TSPAN8 in the entry and exit mechanism of coronaviruses.

CURRENT PHARMACEUTICAL DESIGN (2022)

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Article Multidisciplinary Sciences

Tetraspanin-5-mediated MHC class I clustering is required for optimal CD8 T cell activation

Jeff D. Colbert et al.

Summary: This study reveals a molecular association between Tspan5 and MHC I molecules that is critical for the formation of MHC I nanoclusters and optimal T cell responses to antigens.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Multidisciplinary Sciences

Transmembrane proteins tetraspanin 4 and CD9 sense membrane curvature

Raviv Dharan et al.

Summary: This study uncovers the mechanisms by which tetraspanin4 and CD9, two tetraspanin proteins, prefer positive membrane curvature and play important roles in migrasome formation and oocyte microvilli shaping. These findings shed light on the membrane remodeling processes and provide insights into the functions of tetraspanin proteins.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Multidisciplinary Sciences

Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by tetraspanin CD37

Rens Peeters et al.

Summary: This study identifies CD37 as a crucial membrane protein that inhibits fatty acid metabolism in aggressive B-cell lymphoma. Deletion of CD37 leads to increased fatty acid oxidation and depletion of palmitate from serum. CD37 interacts with the fatty acid transporter FATP1 to inhibit the uptake of palmitate. Inhibition of CD37 results in the uptake and processing of exogenous palmitate into energy and essential building blocks for proliferation. Patients with CD37-negative lymphomas exhibit large lipid deposits and intracellular lipid droplets. Inhibition of carnitine palmitoyl transferase 1 A compromises viability and proliferation of CD37-deficient lymphomas.

NATURE COMMUNICATIONS (2022)

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Article Biochemistry & Molecular Biology

Inhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity

Hongsheng Wang et al.

Summary: This study reveals that CD151 regulates sphingolipid metabolism in osteosarcoma and can be targeted for therapy. CD151 enhances sphingolipid synthesis through SPTCL1 and inhibition of sphingolipid synthesis suppresses clonogenic growth of CD151-overexpression cells. Furthermore, myriocin, an SPTLC1 inhibitor, selectively inhibits tumor growth in CD151-high expression tumors.

CELL AND BIOSCIENCE (2022)

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Article Biology

Machine learning-assisted elucidation of CD81-CD44 interactions in promoting cancer stemness and extracellular vesicle integrity

Erika K. Ramos et al.

Summary: In this study, CD81 was identified as a newly discovered driver of breast cancer stemness and metastasis using a combination of machine learning and experimental investigation. It was found that CD81 interacts with CD44 to promote tumor cell cluster formation and lung metastasis. Further analysis revealed that CD81 and CD44 play a role in endocytosis-related pathways and are involved in the secretion of extracellular vesicles and the promotion of stemness. The coexpression of CD81 and CD44 in human circulating tumor cells suggests their clinical significance in patient outcomes.

ELIFE (2022)

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Article Cell Biology

Single vesicle analysis of CD47 association with integrins and tetraspanins on extracellular vesicles released by T lymphoblast and prostate carcinoma cells

Sukhbir Kaur et al.

Summary: CD47 regulates the trafficking of specific coding and noncoding RNAs into extracellular vesicles (EVs), and the RNA contents of CD47(+) EVs differ from that of CD63(+) EVs released by the same cells. CD47 colocalizes with integrins and CD81 on EVs, but not with CD63 and CD9.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Article Biochemistry & Molecular Biology

Enhanced pentose phosphate pathway activity promotes pancreatic ductal adenocarcinoma progression via activating YAP/MMP1 axis under chronic acidosis

Siyuan Chen et al.

Summary: Acidic microenvironment promotes proliferation and metastasis of pancreatic cancer cells by inhibiting AMPK/Hippo signaling and upregulating MMP1 expression.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Article Cell Biology

TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer

Cefan Zhou et al.

Summary: Pancreatic cancer is characterized by poor prognosis and limited therapeutic options, driving the urgent need for new therapeutic targets. This study identified TSPAN1 as an upregulated gene in pancreatic cancer, correlated with poor patient survival, and demonstrated its role in regulating autophagy. Additionally, the study revealed that TSPAN1 is regulated by MIR454-FAM83A and plays a role in the proliferation of pancreatic cancer cells.

AUTOPHAGY (2021)

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Review Pharmacology & Pharmacy

Anticancer drug resistance: An update and perspective

Ruth Nussinov et al.

Summary: Driver mutations play a critical role in cancer initiation and progression, with drug resistance being a common challenge in pharmacological treatment. The emergence of drug resistance can be attributed to a variety of mechanisms, such as mutations occurring in the same or different proteins, and in the same or parallel pathways. The complexity of genetic alterations and tumor microenvironment changes poses challenges in predicting drug resistance and requires further research in precision medicine.

DRUG RESISTANCE UPDATES (2021)

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Article Cell & Tissue Engineering

CD9, a potential leukemia stem cell marker, regulates drug resistance and leukemia development in acute myeloid leukemia

Yongliang Liu et al.

Summary: CD9 has been identified as a new biomarker for AML LSCs, showing promise as a therapeutic target. CD9(+) cells exhibit higher resistance to chemotherapy drugs and migration potential, with the ability to reconstitute human AML and promote leukemia growth. Additionally, A2M plays a crucial role in maintaining CD9(+) LSC stemness, as knocking down A2M impairs drug resistance and migration of CD9(+) cells.

STEM CELL RESEARCH & THERAPY (2021)

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Article Oncology

TSPAN7 Exerts Anti-Tumor Effects in Bladder Cancer Through the PTEN/PI3K/AKT Pathway

Xi Yu et al.

Summary: This study revealed that downregulation of TSPAN7 in bladder cancer is associated with tumor progression and poor prognosis, and demonstrated the inhibitory effects of TSPAN7 on cancer cell proliferation and migration through multiple experiments. TSPAN7 inhibits bladder cancer cell growth by activating Bax, cleaved caspase-3, and PTEN pathways.

FRONTIERS IN ONCOLOGY (2021)

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Letter Biochemistry & Molecular Biology

Tetraspanin8 expression predicts an increased metastatic risk and is associated with cancer-related death in human cutaneous melanoma

Odile Berthier-Vergnes et al.

MOLECULAR CANCER (2021)

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Article Biotechnology & Applied Microbiology

Tetraspanin 1 (TSPAN1) promotes growth and transferation of breast cancer cells via mediating PI3K/Akt pathway

Yange Wu et al.

Summary: The study revealed that TSPAN1 is highly expressed in breast cancer tumor samples and cell lines, and plays a role in regulating growth and motility through EMT and the PI3K/Akt pathway. Depletion of TSPAN1 suppressed tumor growth in breast cancer in mice, suggesting it could be a potential target for treatment.

BIOENGINEERED (2021)

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Article Cell Biology

High TSPAN8 expression in epithelial cancer cell-derived small extracellular vesicles promote confined diffusion and pronounced uptake

Teng Wang et al.

Summary: sEVs play a key role in intercellular communication, with TSPAN8-sEV promoting interaction with target cells through forced confined diffusion. TSPAN8 holds potential as an important therapeutic target.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Oncology

CD81 Enhances Radioresistance of Glioblastoma by Promoting Nuclear Translocation of Rad51

Wang Zheng et al.

Summary: CD81 is highly expressed in glioblastoma (GBM) and plays a vital role in DNA repair and radioresistance, making it a potential target for GBM therapy.

CANCERS (2021)

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Letter Cell Biology

Nuclear translocation of the 4-pass transmembrane protein Tspan8

Yuwei Huang et al.

CELL RESEARCH (2021)

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Article Oncology

CD151 drives cancer progression depending on integrin α3β1 through EGFR signaling in non-small cell lung cancer

Jianjie Zhu et al.

Summary: The study demonstrated that high expression of CD151 in NSCLC tissues and cell lines is associated with poor prognosis, and its overexpression promotes tumor proliferation, migration, and invasion. CD151 regulates downstream signaling pathways and affects the sensitivity of NSCLC cells to anti-cancer drugs by interacting with integrins and activating the EGFR/ErbB2 signaling pathway.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology

SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer

Junjian Li et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer due to early metastasis and lack of effective therapeutic drugs. Upregulation of TSPAN8 expression in PDAC promotes metastasis, with SOX9 as a key regulator. High levels of SOX9 and TSPAN8 in PDAC are associated with poor prognosis and survival, suggesting TSPAN8 as a potential therapeutic target.

ONCOGENE (2021)

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Article Multidisciplinary Sciences

Tetraspanin 6 is a regulator of carcinogenesis in colorectal cancer

Regina Andrijes et al.

Summary: Tspan6 has been identified as a regulator of CRC development and a potential predictive marker for EGFR-targeted therapies. Studies have shown that the deletion of Tspan6 leads to activation of EGF-dependent signaling pathways, and patients with high Tspan6 levels have better responses to Cetuximab therapy.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Multidisciplinary Sciences

Targeting the tetraspanin CD81 reduces cancer invasion and metastasis

Felipe Vences-Catalan et al.

Summary: Tetraspanins are a family of proteins that play important roles in cell physiology, with studies showing that CD81 antibody can effectively halt invasion of TNBC cell lines. In vivo experiments further confirmed the inhibitory effect of this antibody on metastases.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Cell Biology

Mechanical Control of Cell Migration by the Metastasis Suppressor Tetraspanin CD82/KAI1

Laura Ordas et al.

Summary: The plasma membrane plays a crucial role in controlling cell migration, with caveolae constituents like caveolin-1 initiating mechanotransduction loops and Tetraspanin CD82 regulating membrane tension and YAP nuclear translocation. CD82 acts as a metastasis suppressor by controlling persistent 2D cell migration through caveolin and the YAP pathway.

CELLS (2021)

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Review Oncology

Role of Tetraspanins in Hepatocellular Carcinoma

Sicheng Cai et al.

Summary: HCC is characterized by high prevalence, morbidity, and mortality, with tetraspanins playing important roles in its lifecycle. Some tetraspanins such as CD9, TSPAN15, and TSPAN31 can promote HCC cell proliferation or suppress apoptosis, while CD63, CD151, and TSPAN8 can facilitate HCC metastasis. TSPAN1, TSPAN8, and CD151 act as prognosis indicators and are inversely correlated to the overall survival rate of HCC patients.

FRONTIERS IN ONCOLOGY (2021)

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Article Biochemical Research Methods

Proteomic Landscape of Exosomes Reveals the Functional Contributions of CD151 in Triple-Negative Breast Cancer

Sipeng Li et al.

Summary: This study revealed the proteomic landscape of TNBC-derived exosomes and discovered that CD151 levels in TNBC-derived exosomes were significantly higher than those in exosomes from healthy subjects. CD151 may be a potential therapeutic target for TNBC.

MOLECULAR & CELLULAR PROTEOMICS (2021)

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Article Cell & Tissue Engineering

Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient

Neil McCarthy et al.

CELL STEM CELL (2020)

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Review Biochemistry & Molecular Biology

Amino acid transporters as tetraspanin TM4SF5 binding partners

Jae Woo Jung et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Tetraspanin 33 (TSPAN33) regulates endocytosis and migration of human B lymphocytes by affecting the tension of the plasma membrane

Itze C. Navarro-Hernandez et al.

FEBS JOURNAL (2020)

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Article Biochemistry & Molecular Biology

The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex

Chek Ziu Koo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Article Medicine, Research & Experimental

LncRNA KCNQ1OT1 contributes to the progression and chemoresistance in acute myeloid leukemia by modulating Tspan3 through suppressing miR-193a-3p

Huifang Sun et al.

LIFE SCIENCES (2020)

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Article Medicine, Research & Experimental

TSPAN8 promotes colorectal cancer cell growth and migration in LSD1-dependent manner

Hong-Sheng Zhang et al.

LIFE SCIENCES (2020)

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Article Multidisciplinary Sciences

miR-196b-5p-mediated downregulation of TSPAN12 and GATA6 promotes tumor progression in non-small cell lung cancer

Guang Liang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Multidisciplinary Sciences

Tetraspanin-6 negatively regulates exosome production

Rania Ghossoub et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Cell Biology

Tspan8-Tumor Extracellular Vesicle-Induced Endothelial Cell and Fibroblast Remodeling Relies on the Target Cell-Selective Response

Wei Mu et al.

CELLS (2020)

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Article Cell Biology

LncRNA-LALR1 upregulates small nucleolar RNA SNORD72 to promote growth and invasion of hepatocellular carcinoma

Lin-Hong Mao et al.

AGING-US (2020)

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Review Oncology

Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance

Andriy Marusyk et al.

CANCER CELL (2020)

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Article Biochemistry & Molecular Biology

TSPAN31 suppresses cell proliferation in human cervical cancer through down-regulation of its antisense pairing with CDK4

Yingjie Xia et al.

CELL BIOCHEMISTRY AND FUNCTION (2020)

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Article Multidisciplinary Sciences

Structural insights into tetraspanin CD9 function

Rie Umeda et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Extracellular vesicle tetraspanin-8 level predicts distant metastasis in non-small cell lung cancer after concurrent chemoradiation

Yang Liu et al.

SCIENCE ADVANCES (2020)

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Article Oncology

Tetraspanin CD9 is Regulated by miR-518f-5p and Functions in Breast Cell Migration and In Vivo Tumor Growth

Danielle R. Bond et al.

CANCERS (2020)

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Article Oncology

Tspan8 Drives Melanoma Dermal Invasion by Promoting ProMMP-9 Activation and Basement Membrane Proteolysis in a Keratinocyte-Dependent Manner

Manale El Kharbili et al.

CANCERS (2020)

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Article Biochemistry & Molecular Biology

Tetraspanin CD82 drives acute myeloid leukemia chemoresistance by modulating protein kinase C alpha and β1 integrin activation

Muskan Floren et al.

ONCOGENE (2020)

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Article Hematology

CD81 knockout promotes chemosensitivity and disrupts in vivo homing and engraftment in acute lymphoblastic leukemia

Anthony Quagliano et al.

BLOOD ADVANCES (2020)

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Article Oncology

TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance

Yoelsis Garcia-Mayea et al.

CANCERS (2020)

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Review Oncology

Cancer progression and the invisible phase of metastatic colonization

Christoph A. Klein

NATURE REVIEWS CANCER (2020)

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Article Medicine, Research & Experimental

MGAT3-mediated glycosylation of tetraspanin CD82 at asparagine 157 suppresses ovarian cancer metastasis by inhibiting the integrin signaling pathway

Jun Li et al.

THERANOSTICS (2020)

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Review Biochemistry & Molecular Biology

Molecular principles of metastasis: a hallmark of cancer revisited

Jawad Fares et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Biochemistry & Molecular Biology

Tspan8-β-catenin positive feedback loop promotes melanoma invasion

Manale El Kharbili et al.

ONCOGENE (2019)

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Review Oncology

Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029

Mathilde Bonnet et al.

CANCERS (2019)

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Article Oncology

Tspan8 is expressed in breast cancer and regulates E-cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles

Maren Voglstaetter et al.

JOURNAL OF PATHOLOGY (2019)

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Article Multidisciplinary Sciences

TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling

Rongxuan Zhu et al.

NATURE COMMUNICATIONS (2019)

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Article Oncology

Tspan15 plays a crucial role in metastasis in oral squamous cell carcinoma

Kazuya Hiroshima et al.

EXPERIMENTAL CELL RESEARCH (2019)

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Article Cell Biology

Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains

Yuwei Huang et al.

NATURE CELL BIOLOGY (2019)

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Article Biochemical Research Methods

Tspan15 Is a New Stemness-Related Marker in Hepatocellular Carcinoma

Nazha Sidahmed-Adrar et al.

PROTEOMICS (2019)

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Article Cell Biology

CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth

Victoria M. -Y. Wang et al.

NATURE CELL BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

hTERT promotes tumor progression by enhancing TSPAN13 expression in osteosarcoma cells

Rishi K. Jaiswal et al.

MOLECULAR CARCINOGENESIS (2018)

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Review Cell Biology

Shedding light on the cell biology of extracellular vesicles

Guillaume van Niel et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Article Biotechnology & Applied Microbiology

TSPAN12 is overexpressed in NSCLC via p53 inhibition and promotes NSCLC cell growth in vitro and in vivo

Zhongwu Hu et al.

ONCOTARGETS AND THERAPY (2018)

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Article Multidisciplinary Sciences

TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling

Baozhu Zhang et al.

NATURE COMMUNICATIONS (2018)

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Review Immunology

Tetraspanins as Organizers of Antigen-Presenting Cell Function

Maria Laura Saiz et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Tetraspanin Assemblies in Virus Infection

Luise Florin et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Pharmacology & Pharmacy

Stabilization of the CD81 Large Extracellular Loop with De Novo Disulfide Bonds Improves Its Amenability for Peptide Grafting

Stefan Vogt et al.

PHARMACEUTICS (2018)

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Article Oncology

Discovery of a diagnostic biomarker for colon cancer through proteomic profiling of small extracellular vesicles

Chan-Hyeong Lee et al.

BMC CANCER (2018)

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Article Oncology

Tetraspanin 1 promotes epithelial-to-mesenchymal transition and metastasis of cholangiocarcinoma via PI3K/AKT signaling

Yan Wang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

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Article Biochemistry & Molecular Biology

TSPAN31 is a critical regulator on transduction of survival and apoptotic signals in hepatocellular carcinoma cells

Jianglin Wang et al.

FEBS LETTERS (2017)

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Article Biochemistry & Molecular Biology

CD9 Regulates Major Histocompatibility Complex Class II Trafficking in Monocyte-Derived Dendritic Cells

Vera Rocha-Perugini et al.

MOLECULAR AND CELLULAR BIOLOGY (2017)

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Review Biochemistry & Molecular Biology

Intra-tumor heterogeneity from a cancer stem cell perspective

Pramudita R. Prasetyanti et al.

MOLECULAR CANCER (2017)

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Article Neurosciences

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

Francesc X. Guix et al.

MOLECULAR NEURODEGENERATION (2017)

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Article Multidisciplinary Sciences

The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration

Jennifer Munkley et al.

SCIENTIFIC REPORTS (2017)

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Article Biochemistry & Molecular Biology

TSPAN12 promotes chemoresistance and proliferation of SCLC under the regulation of miR-495

Minting Ye et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Article Hematology

Assessment of CD37 B-cell antigen and cell-of-origin significantly improves risk prediction in diffuse large B-cell lymphoma

Z. Y. Xu-Monette et al.

BLOOD (2016)

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Article Medicine, Research & Experimental

Tetraspanin CD37 protects against the development of B cell lymphoma

Charlotte M. de Winde et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Immunology

Dendritic Cell Migration and Antigen Presentation Are Coordinated by the Opposing Functions of the Tetraspanins CD82 and CD37

Eleanor L. Jones et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Oncology

Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1

Jun Rao et al.

CANCER LETTERS (2015)

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Article Cell & Tissue Engineering

Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia

Hyog Young Kwon et al.

CELL STEM CELL (2015)

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Article Oncology

Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo

Chee Man Cheong et al.

EXPERIMENTAL CELL RESEARCH (2015)

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Article Biochemistry & Molecular Biology

TSPAN1 functions as an oncogene in gastric cancer and is downregulated by miR-573

Zhengmao Lu et al.

FEBS LETTERS (2015)

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Article Cell Biology

Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration

Liang Ma et al.

CELL RESEARCH (2015)

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Article Oncology

The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding

Shijing Yue et al.

ONCOTARGET (2015)

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Review Cell Biology

Biological properties of extracellular vesicles and their physiological functions

Maria Yanez-Mo et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Review Cell Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Marina Colombo et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

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Article Biochemistry & Molecular Biology

Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation

Konstantin Knoblich et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2014)

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Article Oncology

CD82 regulates STAT5/IL-10 and supports survival of acute myelogenous leukemia cells

Chie Nishioka et al.

INTERNATIONAL JOURNAL OF CANCER (2014)

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Article Dermatology

CD63 Tetraspanin Is a Negative Driver of Epithelial-to-Mesenchymal Transition in Human Melanoma Cells

Antonella Lupia et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

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Article Biochemistry & Molecular Biology

RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy

Naoomi Tominaga et al.

MOLECULAR CANCER (2014)

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Article Oncology

The Nuclear Pool of Tetraspanin CD9 Contributes to Mitotic Processes in Human Breast Carcinoma

Germana Rappa et al.

MOLECULAR CANCER RESEARCH (2014)

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Article Multidisciplinary Sciences

The Tetraspanin CD53 Modulates Responses from Activating NK Cell Receptors, Promoting LFA-1 Activation and Dampening NK Cell Effector Functions

Izabela Todros-Dawda et al.

PLOS ONE (2014)

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Review Immunology

Re-examining class-I presentation and the DRiP hypothesis

Kenneth L. Rock et al.

TRENDS IN IMMUNOLOGY (2014)

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Review Oncology

Tetraspanin proteins promote multiple cancer stages

Martin E. Hemler

NATURE REVIEWS CANCER (2014)

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Review Oncology

Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy

Pierre G. Coulie et al.

NATURE REVIEWS CANCER (2014)

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Review Immunology

Pathways of Antigen Processing

Janice S. Blum et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

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Article Oncology

Tspan8 and CD151 promote metastasis by distinct mechanisms

Shijing Yue et al.

EUROPEAN JOURNAL OF CANCER (2013)

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Article Immunology

Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration

Kate H. Gartlan et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2013)

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Article Biochemistry & Molecular Biology

Tetraspanin CD151 Stimulates Adhesion-dependent Activation of Ras, Rac, and Cdc42 by Facilitating Molecular Association between β1 Integrins and Small GTPases

In-Kee Hong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

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Article Gastroenterology & Hepatology

Tspan-1 interacts with the thiamine transporter-1 in human intestinal epithelial cells and modulates its stability

Svetlana M. Nabokina et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2011)

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Article Hematology

CD81 is essential for the formation of membrane protrusions and regulates Rac1-activation in adhesion-dependent immune cell migration

Thomas Quast et al.

BLOOD (2011)

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Article Oncology

Tetraspanin CD151 is a novel prognostic marker in poor outcome endometrial cancer

M. A. Voss et al.

BRITISH JOURNAL OF CANCER (2011)

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Article Immunology

The role of tetraspanin CD63 in antigen presentation via MHC class II

Sven H. Petersen et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2011)

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Article Oncology

Cell Surface Tetraspanin CD9 Mediates Chemoresistance in Small Cell Lung Cancer

Satoshi Kohmo et al.

CANCER RESEARCH (2010)

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Article Immunology

A Complementary Role for the Tetraspanins CD37 and Tssc6 in Cellular Immunity

Kate H. Gartlan et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Oncology

Suppression of TSPAN1 by RNA interference inhibits proliferation and invasion of colon cancer cells in vitro

Li Chen et al.

TUMORI JOURNAL (2010)

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Article Oncology

Tspan-1 is a tetraspanin preferentially expressed by mucinous and endometrioid subtypes of human ovarian carcinomas

Claus-Juergen Scholz et al.

CANCER LETTERS (2009)

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Article Immunology

Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC

Kuo-Ching Sheng et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2009)

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Article Gastroenterology & Hepatology

Role of Overexpression of CD151 and/or c-Met in Predicting Prognosis of Hepatocellular Carcinoma

Ai-Wu Ke et al.

HEPATOLOGY (2009)

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Article Immunology

Tetraspanin CD9 Negatively Regulates Lipopolysaccharide-Induced Macrophage Activation and Lung Inflammation

Mayumi Suzuki et al.

JOURNAL OF IMMUNOLOGY (2009)

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Article Biochemistry & Molecular Biology

Glycosylation of Tetraspanin Tspan-1 at Four Distinct Sites Promotes Its Transition Through the Endoplasmic Reticulum

Claus-Juergen Scholz et al.

PROTEIN AND PEPTIDE LETTERS (2009)

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Article Oncology

CD151 accelerates breast cancer by regulating α6 integrin function, signaling, and molecular organization

Xiuwei H. Yang et al.

CANCER RESEARCH (2008)

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Article Multidisciplinary Sciences

The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface

Julia J. Unternaehrer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Review Cell Biology

Tetraspanin functions and associated microdomains

ME Hemler

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

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Article Biochemistry & Molecular Biology

The CD81 tetraspanin facilitates instantaneous leukocyte VLA-4 adhesion strengthening to vascular cell adhesion molecule 1 (VCAM-1) under shear flow

SW Feigelson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Multidisciplinary Sciences

Tetraspanin CD151 regulates α6β1 integrin adhesion strengthening

J Lammerding et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Article Biochemistry & Molecular Biology

Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1

E Odintsova et al.

CURRENT BIOLOGY (2000)

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Article Cell Biology

The tetraspanin CD9 associates with transmembrane TCF-α and regulates TGF-α-induced EGF receptor activation and cell proliferation

W Shi et al.

JOURNAL OF CELL BIOLOGY (2000)

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