4.5 Article

Expanded Access Program Pralsetinib in Advanced Non-Small Cell Lung Cancer with Rearranged during Transfection (RET) Gene Rearrangement

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Chemistry, Medicinal

Pralsetinib: chemical and therapeutic development with FDA authorization for the management of RET fusion-positive non-small-cell lung cancers

Faraat Ali et al.

Summary: This review article summarizes the development, chemistry, characteristics, and treatment mechanism of Pralsetinib (PRL), as well as its application in the treatment of various solid tumors.

ARCHIVES OF PHARMACAL RESEARCH (2022)

Review Chemistry, Medicinal

Pralsetinib: chemical and therapeutic development with FDA authorization for the management of RET fusion-positive non-small-cell lung cancers

Faraat Ali et al.

Summary: Pralsetinib (PRL) is a novel RET inhibitor used for treatment of specific types of cancers, which has been approved in the United States and Europe. This review article summarizes key information on the development, chemistry, mechanism, pharmacokinetics, and pharmacodynamics of PRL.

ARCHIVES OF PHARMACAL RESEARCH (2022)

Article Oncology

Extrapulmonary tuberculosis in patients with RET fusion-positive non-small cell lung cancer treated with pralsetinib: A Korean single-centre compassionate use experience

Yong-Pyo Lee et al.

Summary: The study presented two cases of extrapulmonary tuberculosis developing during pralsetinib therapy, while demonstrating clinical efficacy in RET fusion-positive non-small cell lung cancer patients. Most adverse events were mild and manageable, but further research is needed to establish the relationship between pralsetinib use and tuberculosis.

EUROPEAN JOURNAL OF CANCER (2021)

Review Medicine, General & Internal

Non-Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment

Narjust Duma et al.

MAYO CLINIC PROCEEDINGS (2019)

Article Biochemistry & Molecular Biology

Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies

Doron Lipson et al.

NATURE MEDICINE (2012)

Article Biochemistry & Molecular Biology

RET, ROS1 and ALK fusions in lung cancer

Kengo Takeuchi et al.

NATURE MEDICINE (2012)