Safety and efficacy of hydroxychloroquine as prophylactic against COVID-19 in healthcare workers: a meta-analysis of randomised clinical trials

Article Infectious Diseases

Hydroxychloroquine for pre-exposure prophylaxis of COVID-19 in health care workers: a randomized, multicenter, placebo-controlled trial Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine (HERO-HCQ)

Susanna Naggie et al.

Summary: In a trial conducted between April and November 2020, it was found that oral HCQ taken as prescribed did not significantly reduce the risk of COVID-19 infection among healthcare workers.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2023)

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Article Infectious Diseases

Daily tenofovir disoproxil fumarate/emtricitabine and hydroxychloroquine for pre-exposure prophylaxis of COVID-19: a double-blind placebo-controlled randomized trial in healthcare workers

Rosa Polo et al.

Summary: This study evaluated the effectiveness of hydroxychloroquine (HCQ) and Tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) as pre-exposure prophylaxis for COVID-19. The results suggest that the use of TDF/FTC and HCQ may have both benefits and risks in preventing COVID-19.

CLINICAL MICROBIOLOGY AND INFECTION (2023)

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Article Biology

Hydroxychloroquine to prevent SARS-CoV-2 infection among healthcare workers: early termination of a phase 3, randomised, open-label, controlled clinical trial

Alejandro Llanos-Cuentas et al.

Summary: This study aimed to evaluate the effectiveness and safety of hydroxychloroquine (HCQ) prophylaxis in preventing SARS-CoV-2 infection in healthcare workers (HCWs) on duty during the COVID-19 pandemic. The results showed no significant difference in the incidence of SARS-CoV-2 infections between the HCQ and control groups. The study had a low statistical power for the primary outcome due to poor participant accrual.

BMC RESEARCH NOTES (2023)

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Article Multidisciplinary Sciences

Hydroxychloroquine for prophylaxis of COVID-19 in health workers: A randomized clinical trial

Jorge Rojas-Serrano et al.

Summary: This study aimed to evaluate the efficacy and safety of hydroxychloroquine for prophylaxis of COVID-19 in health care workers. The results showed that hydroxychloroquine had a slightly higher effect size than placebo in preventing symptomatic COVID-19 infection, but this was not statistically significant.

PLOS ONE (2022)

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Article Infectious Diseases

Safety and tolerability of hydroxychloroquine in health care workers and first responders for the prevention of COVID-19: WHIP COVID-19 Study

John E. McKinnon et al.

Summary: This study demonstrated the safety of using HCQ for chemoprophylaxis against COVID-19 in high-risk populations through a randomized placebo-controlled trial, with no hospitalizations or interventions required for participants.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

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Article Medicine, General & Internal

Hydroxychloroquine plus personal protective equipment versus personal protective equipment alone for the prevention of laboratory-confirmed COVID-19 infections among healthcare workers: a multicentre, parallel-group randomised controlled trial from India

Bharath Kumar Tirupakuzhi Vijayaraghavan et al.

Summary: The use of hydroxychloroquine with personal protective equipment was not found to reduce the proportion of laboratory-confirmed COVID-19 among healthcare workers compared to the use of personal protective equipment alone.

BMJ OPEN (2022)

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Review Medicine, Research & Experimental

Landscape of coronavirus disease 2019 clinical trials: New frontiers and challenges

Susan Halabi et al.

Summary: Researchers conducted a critical review of clinical trials designed during the COVID-19 pandemic, using the ClinicalTrials.gov database to survey trials registered between December 1, 2019 and April 11, 2021. The results showed that a majority of the studies were interventional and focused on hospitalized patients, with varying outcomes, disease severity, and comparators. The researchers emphasized the importance of global coordination and common platforms to achieve clinically meaningful results from clinical trials.

CLINICAL TRIALS (2022)

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Review Public, Environmental & Occupational Health

Systematic review and meta-analysis of randomized trials of hydroxychloroquine for the prevention of COVID-19

Xabier Garcia-Albeniz et al.

Summary: Based on a meta-analysis of randomized trials, hydroxychloroquine (HCQ) may be effective as a preventive measure for COVID-19. However, the misinterpretation of early trial results has caused delays in further research.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2022)

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Article Public, Environmental & Occupational Health

The global inequity in COVID-19 vaccination coverage among health and care workers

Maria Sarah Nabaggala et al.

Summary: This paper presents the global patterns of COVID-19 vaccination coverage among HCWs in 2021, revealing that more than a third of countries failed to achieve a 70% vaccination coverage for their HCWs by the end of the year. The study also highlights significant inequities, with low income countries lagging behind. Additionally, the availability of vaccine doses was identified as a critical factor in determining HCWs vaccination coverage.

INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH (2022)

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Article Infectious Diseases

Hydroxychloroquine in the COVID-19 pandemic era: in pursuit of a rational use for prophylaxis of SARS-CoV-2 infection

Marco Infante et al.

Summary: The clinical evidence suggests that hydroxychloroquine (HCQ) does not provide benefits for the treatment of hospitalized patients with COVID-19 and may even increase the risk of QT interval prolongation and ventricular arrhythmias. The FDA has revoked the Emergency Use Authorization for HCQ and chloroquine for treating COVID-19. The effectiveness of HCQ as a prophylactic measure against COVID-19 still needs to be further investigated.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2021)

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Article Immunology

Hydroxychloroquine as Pre-exposure Prophylaxis for Coronavirus Disease 2019 (COVID-19) in Healthcare Workers: A Randomized Trial

Radha Rajasingham et al.

Summary: A clinical trial investigating hydroxychloroquine prophylaxis for healthcare workers at high risk of exposure to SARS-CoV-2 found that once-weekly or twice-weekly dosing did not significantly reduce the incidence of laboratory-confirmed COVID-19 or COVID-19-compatible illness.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers A Randomized Clinical Trial

Benjamin S. Abella et al.

Summary: This study aimed to evaluate the effectiveness of hydroxychloroquine for preventing the transmission of COVID-19 among hospital-based healthcare workers, but it was terminated early and found no clinical benefit of hydroxychloroquine in this prophylactic strategy.

JAMA INTERNAL MEDICINE (2021)

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Article Medicine, Research & Experimental

Meta-analysis of rare adverse events in randomized clinical trials: Bayesian and frequentist methods

Hwanhee Hong et al.

Summary: In the evaluation of medical products' safety, meta-analysis plays a crucial role and outperforms single randomized controlled trials in estimating adverse event rates. Different meta-analysis models display varying performance, with the beta hyperprior method showing the best results in rare event settings. It is important to consider between-study heterogeneity and compare model performance to obtain reliable treatment effect estimates.

CLINICAL TRIALS (2021)

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Article Anesthesiology

Bayesian predictive probabilities: a good way to monitor clinical trials

David Ferreira et al.

Summary: By simulating a sequential analysis of a clinical trial, this paper illustrates the use of PredP in Bayesian methods. The results demonstrate that the equivalence determined by PredP is more accurate than that from frequentist analysis, allowing for early termination of the trial.

BRITISH JOURNAL OF ANAESTHESIA (2021)

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Article Medicine, Research & Experimental

Pre-exposure prophylaxis with hydroxychloroquine for COVID-19: a double-blind, placebo-controlled randomized clinical trial

Berta Grau-Pujol et al.

Summary: The efficacy and safety of using hydroxychloroquine as COVID-19 PrEP in high-risk healthcare workers have not been fully evaluated, but the study shows that PrEP with low-dose hydroxychloroquine is safe.

TRIALS (2021)

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Article Infectious Diseases

Positive impact of oral hydroxychloroquine and povidone-iodine throat spray for COVID-19 prophylaxis: An open-label randomized trial

Raymond Chee Seong Seet et al.

Summary: The study found that chemoprophylaxis with either oral hydroxychloroquine or povidone-iodine throat spray was superior to oral vitamin C in reducing SARS-CoV-2 infection in young and healthy men. Participants receiving zinc/vitamin C combination had the highest rate of interruptions due to side effects.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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News Item Multidisciplinary Sciences

COVID VACCINES WON'T REACH POOREST COUNTRIES BEFORE 2023

T. V. Padma

NATURE (2021)

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Article Medicine, General & Internal

Pre-exposure Prophylaxis With Various Doses of Hydroxychloroquine Among Healthcare Personnel With High-Risk Exposure to COVID-19: A Randomized Controlled Trial

Fibhaa Syed et al.

Summary: The study concludes that PrEP with HCQ does not significantly prevent COVID-19 among high-risk HCPs. Most participants reported exposure to COVID-19 cases, with a few experiencing mild treatment-related side effects. The use of personal protective equipment varied significantly among the exposed HCPs.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Letter Cell Biology