New prolonged opioid consumption after major surgery in Sweden: a population-based retrospective cohort study

Objective Given that long-term opioid usage is an important problem worldwide and postsurgical pain is a common indication for opioid prescription, our primary objective was to describe the frequency of new prolonged opioid consumption after major surgery in Sweden and, second, to evaluate potential associated risk factors. Design Cohort study including data from 1 January 2007 to 31 December 2014. Data regarding surgical procedures, baseline characteristics and outcomes was retrieved from the Orbit surgical planning system, the Swedish national patient register and the Swedish cause of death register. Setting Observational multicentre cohort study with data from 23 Swedish hospitals. Participants We included 216 877 patients aged >= 18 years, undergoing non-cardiac surgery, not exposed to opioids 180 days before and alive 12 months after surgery. Primary and secondary outcome measures The primary endpoint was collection of at least three opioid prescriptions during the first postoperative year; within 90 days, day 91-180 and 181-365 after surgery in a previously opioid-naive patient. Second, multivariable logistic regression analysis was conducted to explore potential risk factors associated with prolonged opioid use. Results Of the 216 877 patients identified to undergo analysis, 15 081 (7.0%) developed new prolonged opioid consumption. Several risk factors were identified. Having a history of psychiatric disease was identified as the strongest risk factor (adjusted odds ratio: 1.94; 95% CI: 1.87 to 2.00). Conclusion In a large Swedish cohort of surgical patients, 7% developed new prolonged opioid consumption after major surgery. Our data on susceptible patients could help clinicians reduce the number of prolonged opioid users by adapting their analgesic and preventative strategies.

Automated summary

This cohort study aimed to describe the frequency of new prolonged opioid consumption after major surgery in Sweden and identify associated risk factors. The study included data from 216,877 patients from 23 Swedish hospitals. The results showed that 7% of patients developed new prolonged opioid consumption after major surgery, with a history of psychiatric disease being the strongest risk factor.