期刊
BMJ OPEN
卷 13, 期 5, 页码 -出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/bmjopen-2022-071014
关键词
tuberculosis; epidemiology; public health; infectious diseases; health services administration & management
This study examined the impact of interventions on tuberculosis case detection in mining and pastoralist districts in southeastern Ethiopia over a 10-year period. The interventions included training, active case finding, and improving treatment outcomes. The results showed a significant increase in TB case notification in the early post-intervention period and a significant decrease in the late post-intervention period, suggesting the effectiveness of the interventions in reducing the burden of tuberculosis.
ObjectiveTo demonstrate the impact of interventions on tuberculosis (TB) case detection in mining and pastoralist districts in southeastern Ethiopia over a 10-year period. DesignLongitudinal quasi-experimental study. SettingHealth centres and hospitals in six mining districts implemented interventions and seven nearby districts functioned as controls. ParticipantsData from the national District Health Information System (DHIS-2) were used for this study; therefore, people did not participate in this study. InterventionsDirected at training, active case finding and improving treatment outcomes. Primary and secondary outcome measuresPrimarily, trends in TB case notification and percentage of bacteriologically confirmed TB-as collected by DHIS-2-between pre-intervention (2012-2015) and post-intervention (2016-2021) were analysed. Secondarily, post-intervention was split into early post-intervention (2016-2018) and late post-intervention (2019-2021) to also study the long-term effects of the intervention. ResultsFor all forms of TB, case notification significantly increased between pre-intervention and early post-intervention (incidence rate ratio (IRR): 1.21, 95% CI: 1.13, 1.31; p<0.001) and significantly decreased between pre-intervention/early post-intervention and late post-intervention (IRR: 0.82, 95% CI: 0.76, 0.89; p<0.001 and IRR: 0.67, 95% CI: 0.62, 0.73; p<0.001). For bacteriologically confirmed cases, we found a significant decrease between pre-intervention/early post-intervention and late post-intervention (IRR: 0.88, 95% CI: 0.81, 0.97; p<0.001 and IRR: 0.81, 95% CI: 0.74, 0.89; p<0.001). The percentage of bacteriologically confirmed cases was significantly lower in the intervention districts during pre-intervention (B: -14.24 percentage points, 95% CI: -19.27, -9.21) and early post-intervention (B: -7.78, 95% CI: -15.46, -0.010; p=0.047). From early post-intervention to late post-intervention, we found a significant increase (B: 9.12, 95% CI: 0.92 to 17.33; p=0.032). ConclusionsThe decrease in TB notifications in intervention districts during late post-intervention is possibly due to a decline in actual TB burden as a result of the interventions. The unabated increase in case notification in control districts may be due to continued TB transmission in the community.
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