All-cause mortality of hospitalised patients with suspected COVID-19 in Sierra Leone: a prospective cohort study

ObjectivesTo study the mortality of patients with COVID-19 in Sierra Leone, to explore the factors associated with mortality during the COVID-19 pandemic and to highlight the complexities of treating patients with a novel epidemic disease in a fragile health system.Study designA prospective single-centre cohort study. Data were extracted from paper medical records and transferred onto an electronic database. Specific indicators were compared between survivors and non-survivors, using descriptive statistics in Stata V.17.Study settingThe infectious diseases unit (IDU) at Connaught Hospital in Freetown, Sierra LeoneParticipantsParticipants were all patients admitted to the IDU between March and July 2020.Aims of studyThe primary outcome of the study was to examine the all-cause mortality of hospitalised patients with suspected COVID-19 in Sierra Leone and the secondary outcome measures were to examine factors associated with mortality in patients positive for COVID-19.Results261 participants were included in the study. Overall, 41.3% of those admitted to the IDU died, compared with prepandemic in-hospital mortality of 23.8%. Factors contributing to the higher mortality were COVID-19 infection (aOR 5.61, 95% CI 1.19 to 26.30, p=0.02) and hypertension (aOR 9.30, 95% CI 1.18 to 73.27, p=0.03)ConclusionsThis study explores the multiple factors underpinning a doubling in facility mortality rate during the COVID-19 pandemic in Sierra Leone . It provides an insight into the realities of providing front-line healthcare during a pandemic in a fragile health system.

Automated summary

This study aims to study the mortality of patients with COVID-19 in Sierra Leone, explore the factors associated with mortality during the COVID-19 pandemic, and highlight the complexities of treating patients with a novel epidemic disease in a fragile health system. The study found that the in-hospital mortality rate of COVID-19 patients in Sierra Leone was 41.3%, compared to the pre-pandemic rate of 23.8%. Factors contributing to the higher mortality were COVID-19 infection and hypertension.