Salt-Triggered Adaptive Dissociation Coating with Dual Effect of Antibacteria and Anti-Multiple Encrustations in Urological Devices

Bacterial infections and multiple encrustations are life-threatening complications in patients implanted with urological devices. Limited by time-consuming procedures and substrate dependence, it is difficult to simultaneously prevent the aforementioned complications. Herein, is reported the design of a salt-triggered chondroitin sulfate complex (CS/Si-N+) coating with adaptive dissociation, which realizes the dual functions of antibacterial and anti-multiple encrustations in urological devices with arbitrary shapes. The existence of covalent interactions between the complex and the interface ensures the formation of a robust coating, especially in harsh environments. Benefiting from the adaptive dissociation of the ion pairs in the CS/Si-N+ coating in urine electrolytes, the exposed ion groups and enhanced hydrophilicity are more conducive to the inhibition of bacterial infection and multiple encrustations simultaneously. The coating exhibits broad-spectrum bactericidal effects. As a proof of concept, in a simulated metabolic encrustation model, the coating exhibits significant advantages in resisting calcium oxalate encrustation, with a reduction in the calcium content by over 90%. In addition, this non-leachable all-in-one coating shows good biocompatibility in a pig in vivo model. Such a coating strategy is expected to be a practical approach for preventing urological medical device-related complications.

Automated summary

A salt-triggered chondroitin sulfate complex (CS/Si-N+) coating with adaptive dissociation has been designed to prevent bacterial infections and multiple encrustations in urological devices. The coating has covalent interactions with the interface, making it robust even in harsh environments. The adaptive dissociation of ion pairs in the coating enhances its antibacterial and anti-encrustation properties. The coating shows broad-spectrum bactericidal effects and significant advantages in resisting calcium oxalate encrustation.