相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。
Article
Chemistry, Multidisciplinary
Lin Huang et al.
Summary: This study proposes a strategy of limited-space controlled aggregation to enhance the drug loading capability of magnetic resonance imaging contrast agents (MRI CAs). By utilizing exceedingly small gadolinium oxide nanoparticles (GO) and Gd poly(acrylic acid) macrochelate (GP) as MRI CAs, the drug doxorubicin (D) is successfully loaded into the hollow core of hollow mesoporous organosilica nanoparticles (HMONs), resulting in higher drug loading contents. The degradation of HMONs triggered by glutathione (GSH) in the tumor microenvironment and controlled drug release behaviors enhance the chemotherapy efficacy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Bin Liu et al.
Summary: A hyaluronic acid modified calcium and copper peroxides nanocomposite has been synthesized in this study, which can release abundant Ca2+, Cu2+, and H2O2 in the tumor microenvironment, enhancing the antitumor efficiency through different pathways.
Article
Chemistry, Multidisciplinary
Sagang Koo et al.
Summary: The study presents a heterogeneous chemodynamic therapy (CDT) system based on copper-iron peroxide nanoparticles for synergistic therapy in the tumor microenvironment (TME). The system demonstrates excellent tumor therapeutic efficacy by enhancing hydroxyl radical production through a highly efficient catalytic loop. It also generates O-2 and exhibits TME-responsive T-1 magnetic resonance imaging contrast enhancement.
Article
Chemistry, Multidisciplinary
Ke Li et al.
Summary: A Cu-TCPP(Fe) MOF-based nanosystem incorporating Au nanoparticles and RSL3 is reported in this study, which can universally suppress the antiferroptotic pathway in tumor cells and amplify ferroptotic damage. The nanosystem exhibits enzyme-like activities and can inhibit the antioxidant mechanisms involved in ferroptosis.
Article
Chemistry, Multidisciplinary
Yuanyuan Ma et al.
Summary: This study achieved targeted delivery of cisplatin using biocompatible and biodegradable hollow mesoporous organosilica (HMOS) nanoparticles by blocking the pores with a bimetallic Zn2+/Cu2+ co-doped metal-organic framework (MOF). The MOF decomposes in the acidic tumor microenvironment to release cisplatin for chemotherapy, while the released Cu2+ depletes intracellular glutathione (GSH) and catalyzes the decomposition of intratumoral H2O2 into highly toxic •OH for chemodynamic therapy. The reduced GSH also protects the •OH from scavenging, enhancing the chemodynamic therapy effect.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xuxian Su et al.
Summary: The designed CA-Re photosensitizer can efficiently perform photodynamic therapy under hypoxic conditions and improve tumor immunogenicity through pyroptotic cell death, activating immune cells to ultimately eliminate tumors.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Biomedical
Si-Yuan Peng et al.
Summary: The Fe/Se-CaP nanohybrid is developed to trigger a ROS storm in cancer cells by catalyzing the decomposition of GSH to O-2(center dot-) and center dot OH. The therapy induces apoptosis of cancer cells and suppresses tumor progression by elevating oxidative stress and destroying the antioxidant system. In addition, Fe/Se-CaP can catalyze the conversion of H2O2 to center dot OH. This study provides an innovative approach for ROS-involved anti-tumor therapies.
Article
Chemistry, Multidisciplinary
Songtao Zhang et al.
Summary: This paper describes the synthesis of a novel nanotheranostic agent that is responsive to tumor microenvironments and can achieve synergistic cancer therapy focused on the mitochondria under magnetic resonance imaging guidance.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Guoqiang Guan et al.
Summary: Researchers have developed a novel nanoplatform for ferroptosis therapy and can monitor the process in real-time using high-field MRI.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Renye Yue et al.
Summary: A tumor-microenvironment-targeted and co-activated catalytic nanoplatform (CACN) has been developed for specific ferroptosis treatment of cancer cells or tumors. The catalytic activity of CACN can be turned on by dual stimuli of ATP and slight acidity in the tumor microenvironment. The switchable MRI signal of CACN is correlated with reactive oxygen species generation and drug release, allowing for monitoring the therapeutic process.
Article
Chemistry, Multidisciplinary
Shuai Guo et al.
Article
Engineering, Biomedical
Ju-E Cun et al.
Summary: This study reports on an IR-780 decorated nanocomposite, IFM, which achieves photo-enhanced tumor catalytic therapy by integrating the excellent peroxidase-like activity of IFM, selective upregulation of tumoral H2O2 by beta-lapachone, and localized hyperthermia by near infrared light irradiation. The therapy shows potent antitumor efficacy by generating highly cytotoxic center dot OH radicals and depleting glutathione in cancer cells, leading to redox dyshomeostasis and cell death. In vivo investigations demonstrate a high tumor inhibition rate of 96.4% with photoacoustic and fluorescence imaging-guided combinational therapy.
Article
Multidisciplinary Sciences
Shiqi Wu et al.
Summary: This study reveals the mechanism of GPD2 in defense against ferroptosis, suppressing mitochondrial ferroptosis by generating ubiquinol. This finding provides a new avenue for targeting ferroptosis in disease treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Huimin Zhou et al.
Summary: This study proposes a new concept of cycloacceleration of reactive oxygen species (ROS) generation in tumor cells to achieve high-performance ferroptosis therapy (FT) for tumors. By preparing a magnetic resonance imaging (MRI) contrast agent and loading a drug, the hybrid nanoparticles can work with the tumor microenvironment and generate cyclic reactions in tumor cells, resulting in specific cycloacceleration of ROS generation for high-performance FT. Additionally, these nanoparticles can be used for MRI-guided tumor therapy.
Article
Chemistry, Multidisciplinary
Zhe Dong et al.
Summary: In this study, a novel nanoplatform was designed to enhance the effectiveness of ferroptosis-based cancer therapy. The nanoplatform successfully overcame the hypoxia-induced resistance of ferroptosis by providing oxygen supply and breaking down lipid droplets. The results showed that the nanoplatform induced higher levels of oxidative stress, lipid peroxidation, and GSH depletion, leading to effective inhibition of tumor growth. Furthermore, the release of manganese from the nanoplatform could be monitored using imaging techniques.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Medicine, Research & Experimental
Lingling Lei et al.
Summary: In this study, zinc-fluorouracil metallodrug networks (Zn-Fu MNs) were designed to enhance immune activity and ROS production. Zn-Fu MNs were found to respond to acidity and ATP, releasing fluorouracil and zinc ions to induce ferroptosis in cancer cells. The synergistic effect of DNA damage and ferroptosis promoted immunogenic cell death and immune cell activation.
Article
Chemistry, Multidisciplinary
Peng Wang et al.
Summary: A new click-activated prodrug, CA4V, and a bioorthogonal nanoreactor, CA4V/ZIF-90@TzCOF@Apt, are reported. The nanoreactor, consisting of a ZIF-90 core, COF shells, and an aptamer polymer coating, induces a nanoconfined bioorthogonal reaction, enhancing the activation efficiency of CA4V and its therapeutic effects in vivo.
CHEMICAL COMMUNICATIONS
(2022)
Review
Oncology
Guang Lei et al.
Summary: This article provides an overview of the importance and potential of ferroptosis in cancer research, summarizes the mechanisms of ferroptosis induction and defense, analyzes its roles and mechanisms in tumor suppression and tumor immunity, and explores therapeutic strategies targeting ferroptosis in cancer.
NATURE REVIEWS CANCER
(2022)
Article
Nanoscience & Nanotechnology
Wenbao Zuo et al.
Summary: Fe-based nanomaterials with Fenton reaction activity show promise for tumor-specific chemodynamic therapy (CDT). However, low catalytic efficiency and high tumor intracellular pH have limited their clinical application. In this study, macrophage membrane-camouflaged hollow mesoporous ferric oxide (HMFe) nanocatalysts loaded with a carbonic anhydrase IX inhibitor (CAI) were developed to remodel the tumor microenvironment and enhance CDT. The HMFe acted as a Fenton agent with high active-atom exposure, while also providing a hollow cavity for CAI loading. The macrophage membrane-camouflaging improved immune evasion and tumor-specific accumulation, enabling self-amplified CDT and inhibition of tumor metastasis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Yuedong Guo et al.
Summary: This study focuses on using endogenous copper ions as a source of Fenton-like agents in cancer treatment, to disrupt the intrinsic protection pathway of cancer cells and induce apoptosis through catalytic oxidative damage reactions. The nanocatalyst shows excellent biosafety and enhanced therapeutic efficacy by simultaneously targeting cancer cell self-protection mechanisms and inducing oxidative damage.
Review
Chemistry, Multidisciplinary
Yaofeng Zhou et al.
Summary: Various strategies have been developed to increase the efficiency of the intratumoral Fenton reaction in chemodynamic therapy (CDT), enhancing the therapeutic efficacy. The introduction of reinforcement strategies can improve treatment efficiency and promote the development of enhanced CDT-based multimodal anticancer therapies.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Lian-Hua Fu et al.
Summary: Chemodynamic therapy (CDT) is a promising method for killing cancer cells by converting intracellular hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals ((OH)-O-center dot). An intelligent nanocatalytic theranostics, PGC-DOX, was developed to address the limitations of endogenous H2O2 and high GSH levels in tumor cells, leading to efficient cancer therapy. The system combines H2O2 self-supply, GSH-elimination, and DOX-induced chemotherapy to effectively inhibit tumor growth with minimal side effects in vivo.
ADVANCED MATERIALS
(2021)
Review
Cell Biology
Xuejun Jiang et al.
Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Linan Shi et al.
Summary: A novel nanoplatform was developed in this study, which can achieve high-efficient tumor-specific catalytic anticancer treatment in acidic tumor microenvironments through a cyclic amplification strategy, leading to enhanced Fenton-like reaction. Ultimately, this smart nanoplatform enables self-boosting generation of reactive oxygen species (ROS), inducing strong intracellular oxidative stress, and resulting in substantial anticancer outcomes in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Mengyu Chang et al.
Summary: Photothermal therapy (PTT) is a promising tumor therapeutic modality, but minimizing damage to healthy tissues while maximizing efficiency is crucial. Utilizing a single-atom nanozyme (SAzyme) can improve the effectiveness of mild PTT by promoting ferroptosis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Huan Liang et al.
Summary: This study synthesized ultrasmall single-crystal Fe nanoparticles that showed high activity in inducing tumor cell ferroptosis and immunogenetic cell death in the tumor microenvironment at a low concentration. These nanoparticles effectively suppressed tumor growth, promoted dendritic cell maturation, and triggered T cell response in animal models, and when combined with immune checkpoint blockade therapy, they greatly enhanced the immune response and developed strong immune memory. Furthermore, the nanoparticles were quickly excreted in the kidneys without side effects in normal tissues.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Multidisciplinary Sciences
Chenyao Wu et al.
Summary: This study introduces a non-ferrous ferroptosis-like strategy based on a hybrid CoMoO4-phosphomolybdic acid nanosheet (CPMNS), which achieves efficient anticancer efficacy through specific mechanisms. The high feasibility of this approach in nanocatalytic medicine is expected to advance cancer therapeutic regimens in the future.
Article
Multidisciplinary Sciences
Shawn C. Chafe et al.
Summary: The study identified a redox homeostasis network involving the iron-sulfur cluster enzyme NFS1 in the survival mechanisms governed by the tumor hypoxia-induced pH regulator CAIX. Targeting CAIX while depleting NFS1 or blocking cyst(e)ine availability enhanced ferroptosis and inhibited tumor growth significantly. Altering intracellular pH and iron homeostasis through inhibiting CAIX activity may lead to the development of innovative therapeutic strategies for solid tumors to overcome hypoxia- and acidosis-mediated tumor progression and therapeutic resistance.
Article
Chemistry, Multidisciplinary
Xiaoyan Chen et al.
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Ling Li et al.
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Cell Biology
Hyemin Lee et al.
NATURE CELL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Chen-Cheng Xue et al.
Article
Chemistry, Multidisciplinary
Qian Cao et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Review
Oncology
Shen-Han Lee et al.
Article
Chemistry, Multidisciplinary
Sheng Wang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Chemistry, Multidisciplinary
Shanshan Gao et al.
Article
Chemistry, Multidisciplinary
Hadi Ranji-Burachaloo et al.
Article
Chemistry, Multidisciplinary
Di-Wei Zheng et al.
Article
Chemistry, Multidisciplinary
Ping Huang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Chemistry, Multidisciplinary
Hyo Sung Jung et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Chemistry, Multidisciplinary
Mingzhou Ye et al.
ADVANCED MATERIALS
(2017)
Article
Multidisciplinary Sciences
E. Bourseau-Guilmain et al.
NATURE COMMUNICATIONS
(2016)
Article
Oncology
Yuanmei Lou et al.
