4.7 Article

Secondary Structure in Overcoming Photosensitizers' Aggregation: α-Helical Polypeptides for Enhanced Photodynamic Therapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

A Photosensitizer Discretely Loaded Nanoaggregate with Robust Photodynamic Effect for Local Treatment Triggers Systemic Antitumor Responses

Hao Zhao et al.

Summary: This study demonstrates a strategy to enhance the efficacy of photodynamic therapy (PDT) by optimizing the aggregation degree of indocyanine green (ICG) nanoaggregates. The improved PDT efficacy promotes immunogenic cell death (ICD) and systemic antitumor responses via local treatment.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Tailoring Aggregation Extent of Photosensitizers to Boost Phototherapy Potency for Eliciting Systemic Antitumor Immunity

Hao Zhao et al.

Summary: A discretely integrated nanofabrication (DIN) platform has been developed to optimize phototherapy efficacy and enhance antitumor immunity.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Aggregation-Enhanced Sonodynamic Activity of Phthalocyanine-Artesunate Conjugates

Peng-Hui Zhao et al.

Summary: The study designed a novel sonosensitizer ZnPcT(4)A, which exhibited significantly enhanced sonodynamic activity in its aggregated state. This enhancement effect may be attributed to the boosted ultrasonic cavitation of nanostructures, and the level of this effect depends on the aggregation ability of sonosensitizer molecules and the particle size of their aggregates. Additionally, biological experiments demonstrated that ZnPcT(4)A has high anticancer activity and biosafety.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Article Engineering, Biomedical

Cationization to boost both type I and type II ROS generation for photodynamic therapy

Yuewen Yu et al.

Summary: In this study, a cationization molecular engineering strategy was used to enhance the generation of reactive oxygen species (ROS) for efficient photodynamic therapy (PDT). The cationization process improved the aggregation-induced emission (AIE) feature, promoted intersystem crossing (ISC) processes, and increased charge transfer and separation ability, leading to the efficient production of ROS, particularly hydroxyl and superoxide radicals. Additionally, the cationic AIE photosensitizers also exhibited specific cancer cell mitochondrial targeting capability, which further improved the efficacy of PDT.

BIOMATERIALS (2022)

Article Chemistry, Multidisciplinary

Enhancing Intersystem Crossing by Intermolecular Dimer-Stacking of Cyanine as Photosensitizer for Cancer Therapy

Haiqiao Huang et al.

Summary: The development of new photosensitizers with high singlet oxygen quantum yield and minimal side effects is important in photodynamic therapy. In this study, a simple strategy was demonstrated to significantly improve photosensitization by connecting two pentamethine dyes with varying alkyl chains, resulting in a series of cyanine dimers. The dimers showed enhanced absorption, better singlet oxygen quantum yield, and longer triplet-state lifetime compared to the monomer, making them excellent candidates for triplet photosensitizers. In vivo experiments confirmed that one of the dimers successfully suppressed tumor growth after PDT treatment.

CCS CHEMISTRY (2022)

Review Chemistry, Multidisciplinary

Emerging Designs of Aggregation-Induced Emission Agents for Enhanced Phototherapy Applications

Rui Qu et al.

Summary: This review summarizes the recent advances in the development of aggregation-induced emission (AIE) phototherapy agents for enhanced photodynamic therapy (PDT) and photothermal therapy (PTT) performances in biomedical applications. It discusses the design strategies of AIE agents to boost reactive oxygen species (ROS) generation or regulate ROS types, as well as the designs and examples of AIE agents that enhance PTT performances through molecular motions.

CCS CHEMISTRY (2022)

Article Chemistry, Multidisciplinary

Cationization-Enhanced Type I and Type II ROS Generation for Photodynamic Treatment of Drug-Resistant Bacteria

Shanshan Liu et al.

Summary: This article introduces a molecular cationization approach to enhance the generation of reactive oxygen species (ROS) by aggregation-induced emission (AIE) photosensitizers, especially type I ROS, for photodynamic treatment of drug-resistant bacteria.

ACS NANO (2022)

Article Engineering, Environmental

Glutathione depletion and photosensitizer activation augments efficacy of tumor photodynamic immunotherapy

Yuchen Du et al.

Summary: Photodynamic therapy (PDT) is a promising clinical therapy that activates anti-tumor immunity by inducing immunogenicity of tumor cells. However, its effectiveness is limited by the high concentration of glutathione (GSH) in tumor cells and the quenching effect of photosensitizers. This study developed a drug delivery system, PSSP, which effectively depleted GSH and activated photosensitizers, leading to more efficient immunogenic cell death and tumor elimination.

CHEMICAL ENGINEERING JOURNAL (2022)

Review Chemistry, Inorganic & Nuclear

Strategies to construct efficient singlet oxygen-generating photosensitizers

E. Pang et al.

Summary: This article systematically summarizes various strategies to improve the generation efficiency of singlet oxygen (O-1(2)) in photosensitizers (PS) and discusses their advantages, disadvantages, and challenges.

COORDINATION CHEMISTRY REVIEWS (2022)

Article Chemistry, Multidisciplinary

Confining isolated photosensitizers to relieve self-aggregation and potentiate photodynamic efficacy for synergistic cancer therapy

Gang Liu et al.

Summary: In this study, a new insight into alleviating ACQ by precisely tailoring the aggregation extent of photosensitizers is revealed through the concise and facile coordination co-assembly fabrication of Pt/TCPP NCPs. By optimizing the aggregation extent, outstanding PDT efficacy for robustly synergistic cancer PDT/chemotherapy is achieved.

CHEMICAL COMMUNICATIONS (2022)

Article Nanoscience & Nanotechnology

BOPHY-Based Aggregation-Induced-Emission Nanoparticle Photosensitizers for Photodynamic Therapy

Fangyuan Lv et al.

Summary: Photosensitizer BOPHY-2TPA, with a donor-acceptor-donor structure, showed excellent O-1(2) generation capabilities and avoided the ACQ effect due to its twisted TPAs structure, resulting in high PDT antitumor efficiency when encapsulated with Pluronic P123 in aqueous solution.

ACS APPLIED NANO MATERIALS (2021)

Review Pharmacology & Pharmacy

Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation

Yunjiang Jiang et al.

Summary: AMPs and SMAMPs have attracted significant enthusiasm in the past thirty years due to their unique membrane-active antimicrobial mechanism and broad-spectrum antimicrobial activity. Despite challenges inherent to current design strategies slowing down the clinical translational development of AMPs and SMAMPs, these challenges have triggered efforts to redesign and repurpose AMPs.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Chemistry, Multidisciplinary

Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Thanh Chung Pham et al.

Summary: This review presents a robust strategy for designing photosensitizers for different species, highlighting the importance of organic PSs in photodynamic therapy. While previous studies have focused on nanomaterials and traditional PSs, this review sets out to report recent innovative strategies for developing organic photosensitizers for enhanced PDT, providing detailed examples to offer intuitive and specific insights to readers.

CHEMICAL REVIEWS (2021)

Article Chemistry, Multidisciplinary

An acid-triggered porphyrin-based block copolymer for enhanced photodynamic antibacterial efficacy

Fan Yu et al.

Summary: Researchers developed an acid-triggered nanoplatform to enhance photodynamic antibacterial activity by reducing the aggregation of photosensitizers in bacterial acidic microenvironment. The nanoparticles, formed by self-assembly, could rapidly acquire positive charge in acidic bacterial media, effectively adhering to negatively charged bacterial cell membranes.

SCIENCE CHINA-CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Nanoscale Metal-Organic Layer Isolates Phthalocyanines for Efficient Mitochondria-Targeted Photodynamic Therapy

Geoffrey T. Nash et al.

Summary: A new nanoscale metal-organic layer assembly, ZnOPPc@nMOL, has been designed for photodynamic therapy (PDT), which shows exceptional efficacy in inhibiting tumor growth and curing colon cancer in mouse models. The assembly efficiently sensitizes the formation of singlet oxygen by preventing aggregation-induced self-quenching of ZnOPPc excited states. With intrinsic mitochondria-targeting capability, ZnOPPc@nMOL displays strong potential for clinical applications in PDT.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Review Engineering, Biomedical

Polypeptides-Drug Conjugates for Anticancer Therapy

Yu Zhang et al.

Summary: Polypeptides are important biodegradable polymers widely used in drug delivery for cancer treatment. Conjugating anticancer drugs with polypeptides offers advantages in improving pharmacokinetics, enhancing targeting, and controlling drug release, contributing to enhanced therapeutic outcomes with reduced side effects.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Nanoscience & Nanotechnology

Cationic Polyporphyrins as siRNA Delivery Vectors for Photodynamic and Gene Synergistic Anticancer Therapy

Nan Zheng et al.

Summary: This study introduces a library of polymerized and cationic photosensitive drugs (pPSs) with HIF-1 alpha siRNA delivery capability for gene therapy. By using a ROS-cleavable linker, successful segregation of PS monomers was achieved, enhancing the PDT effect. The drug exhibited desired siRNA delivery and gene silencing both in vitro and in vivo.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Engineering, Biomedical

Mitochondria-targeting and ROS-sensitive smart nanoscale supramolecular organic framework for combinational amplified photodynamic therapy and chemotherapy

Jia Tian et al.

Summary: A smart SOF platform has been proposed for enhanced photodynamic therapy, targeting mitochondria and releasing photosensitizers and DOX autonomously for high anti-cancer activity. The unique supramolecular framework solves aggregation-caused quenching of photosensitizers and enhances their water-solubility, showing potential for versatile agents in combined therapies.

ACTA BIOMATERIALIA (2021)

Article Chemistry, Multidisciplinary

A Bifunctional Zwitterion-Modified Porphyrin for Photodynamic Nondestructive Tooth Whitening and Biofilm Eradication

Hao Zhang et al.

Summary: A bifunctional photodynamic dental therapy (PDDT) strategy based on ZMP has been developed for tooth whitening and biofilm eradication, showing superior ROS output and ability to disintegrate extracellular polymeric substances compared to PP. This new approach highlights the potential of ZMP as a photosensitizer for clinical dentistry in addressing tooth whitening and biofilm-induced dental diseases.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Engineering, Biomedical

Polypeptide-based drug delivery systems for programmed release

Xu Wang et al.

Summary: Recent years have witnessed increasing interest in using ring-opening polymerization of NCAs to prepare synthetic polypeptides for various biomedical applications. Polypeptides, with their rich side-chain functionalities, diverse hydrophilicity/hydrophobicity profiles, and stable secondary structures, can assemble into well-organized nano-structures that offer unique advantages in drug delivery and controlled release. This review focuses on the design and use of polypeptide-based drug delivery systems derived from NCA chemistry, discussing their potential to change the landscape of next-generation therapeutics and diagnosis.

BIOMATERIALS (2021)

Article Chemistry, Multidisciplinary

Self-assembly of amphiphilic peptides to construct activatable nanophotosensitizers for theranostic photodynamic therapy

Shuang Chen et al.

Summary: Novel acid-activatable self-assembled nanophotosensitizers based on an amphiphilic peptide derivative have been developed, showing specific tumor cell entry and disassembly inside lysosomes, with fluorescence turn-on and photodynamic therapy effect. These smart nanophotosensitizers offer new opportunities for cancer theranostics.

CHINESE CHEMICAL LETTERS (2021)

Review Chemistry, Inorganic & Nuclear

Photodynamic therapy for hypoxic tumors: Advances and perspectives

Li Huang et al.

Summary: Photodynamic therapy (PDT) is a preferred clinical technology for treating tumors, but the hypoxic tumor microenvironment weakens its efficiency. Strategies for improving PDT efficacy in hypoxic tumors include increasing oxygen concentration, disregarding hypoxia, and exploiting hypoxia. Combining PDT with other therapeutics can also enhance treatment outcomes.

COORDINATION CHEMISTRY REVIEWS (2021)

Review Chemistry, Multidisciplinary

Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies

Jianlei Xie et al.

Summary: Photodynamic therapy (PDT) has shown great potential in tumor treatment due to its non-invasiveness, spatiotemporal selectivity, lower side-effects, and immune activation ability. However, the clinical application of PDT is restricted by various factors such as traditional photosensitizer limitations, light penetration issues, tumor resistance, and pain induction. Recent advancements in using nanomaterials as photosensitizers or carriers, combined with optimized therapy strategies, have shown promising results in overcoming these barriers and improving the effectiveness of PDT in cancer treatment.

CHEMICAL SOCIETY REVIEWS (2021)

Article Materials Science, Biomaterials

Linear and high-molecular-weight poly-porphyrins for efficient photodynamic therapy†

Nan Zheng et al.

Summary: This study developed a linear polymeric porphyrin with structure defects to overcome the aggregation caused quenching (ACQ) effect in photosensitizers. Poly-porphyrins demonstrated enhanced singlet oxygen generation ability compared to porphyrin monomers, with the singlet oxygen quantum yield increasing with the molecular weight of the poly-porphyrins.

BIOMATERIALS SCIENCE (2021)

Article Chemistry, Multidisciplinary

Enhancing Intersystem Crossing by Intermolecular Dimer-Stacking of Cyanine as Photosensitizer for Cancer Therapy

Haiqiao Huang et al.

Summary: This study demonstrates a facile strategy to significantly improve photosensitization by connecting two pentamethine dyes to form a series of cyanine dimers. The dimers exhibit enhanced photophysical properties, with higher near-infrared absorption, better singlet oxygen quantum yield, and longer triplet-state lifetime compared to monomers, showing potential for tumor growth inhibition in PDT treatment.

CCS CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Self-Amplified Photodynamic Therapy through the 1O2-Mediated Internalization of Photosensitizers from a Ppa-Bearing Block Copolymer

Zhiyong Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Semiconducting Polymer Dots with Dual-Enhanced NIR-IIa Fluorescence for Through-Skull Mouse-Brain Imaging

Zhe Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Switching the Photoluminescence and Electrochemiluminescence of Liposoluble Porphyrin in Aqueous Phase by Molecular Regulation

Yinpan Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Review Chemistry, Inorganic & Nuclear

Recent advances of multi-dimensional porphyrin-based functional materials in photodynamic therapy

Jia Tian et al.

COORDINATION CHEMISTRY REVIEWS (2020)

Article Chemistry, Multidisciplinary

Porphyrin Nanocage-Embedded Single-Molecular Nanoparticles for Cancer Nanotheranostics

Guocan Yu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Engineering, Biomedical

Photosensitizers for Photodynamic Therapy

Minhuan Lan et al.

ADVANCED HEALTHCARE MATERIALS (2019)

Article Nanoscience & Nanotechnology

Acid-Triggered Nanoexpansion Polymeric Micelles for Enhanced Photodynamic Therapy

Sheng Zhong et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Article Nanoscience & Nanotechnology

NIR-Triggered OFF/ON Photodynamic Therapy through a Upper Critical Solution Temperature Block Copolymer

Dawei Jiang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Article Chemistry, Multidisciplinary

Polymerization-Enhanced Photosensitization

Wenbo Wu et al.

Article Chemistry, Multidisciplinary

Enhancing the Efficacy of Photodynamic Therapy through a Porphyrin/POSS Alternating Copolymer

Jiangui Jin et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Review Chemistry, Physical

Advances in Stimuli-Responsive Polypeptide Nanogels

Zhongyu Jiang et al.

SMALL METHODS (2018)

Review Chemistry, Multidisciplinary

Advancing porphyrin's biomedical utility via supramolecular chemistry

M. A. Rajora et al.

CHEMICAL SOCIETY REVIEWS (2017)

Article Chemistry, Multidisciplinary

Sequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors

Jinjin Chen et al.

ADVANCED MATERIALS (2017)

Article Nanoscience & Nanotechnology

Spatiotemporal Control of Supramolecular Self-Assembly and Function

Jie Zhan et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Article Chemistry, Multidisciplinary

Anaerobe-Inspired Anticancer Nanovesicles

Chenggen Qian et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Review Chemistry, Multidisciplinary

Synthesis of Side-Chain Modified Polypeptides

Timothy J. Deming

CHEMICAL REVIEWS (2016)

Article Nanoscience & Nanotechnology

Synthesis and Biological Properties of Porphyrin-Containing Polymeric Micelles with Different Sizes

Jialiang Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Review Chemistry, Multidisciplinary

Overcoming the Achilles' heel of photodynamic therapy

Wenpei Fan et al.

CHEMICAL SOCIETY REVIEWS (2016)

Review Chemistry, Multidisciplinary

Porphyrin-loaded nanoparticles for cancer theranostics

Yiming Zhou et al.

NANOSCALE (2016)

Article Polymer Science

Porphyrin-containing amphiphilic block copolymers for photodynamic therapy

Lei Xu et al.

POLYMER CHEMISTRY (2015)

Article Multidisciplinary Sciences

Helical antimicrobial polypeptides with radial amphiphilicity

Menghua Xiong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Pharmacology & Pharmacy

Design and development of dendrimer photosensitizer-incorporated polymeric micelles for enhanced photodynamic therapy

Nobuhiro Nishiyama et al.

ADVANCED DRUG DELIVERY REVIEWS (2009)

Article Chemistry, Physical

GROMACS 4: Algorithms for highly efficient, load-balanced, and scalable molecular simulation

Berk Hess et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2008)

Article Chemistry, Multidisciplinary

Factors influencing self-aggregation tendencies of cationic porphyrins in aqueous solution

K Kano et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)