4.7 Article

Rapid and Facile Light-Based Approach to Fabricate Protease-Degradable Poly(ethylene glycol)-norbornene Microgels for Cell Encapsulation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Materials Science, Biomaterials

Dissolvable microgel-templated macroporous hydrogels for controlled cell assembly

Zhongliang Jiang et al.

Summary: This study reports the fabrication of MSC-laden macroporous hydrogel scaffolds using rapidly dissolvable spherical cell-laden microgels. The method is cytocompatible and allows for the formation of solid or hollow cell spheroids by adjusting the stiffness and cell adhesiveness of the hydrogels. MSC solid spheroids formed in the macroporous hydrogels exhibit robust secretion of various proteins.

BIOMATERIALS ADVANCES (2022)

Article Engineering, Biomedical

High-Throughput On-Chip Human Mesenchymal Stromal Cell Potency Prediction

Rebecca S. Schneider et al.

Summary: Human mesenchymal stromal cells (hMSCs) are a promising source for regenerative cell therapy, but their clinical use is hindered by product variability and the inability to predict efficacy. Current potency assays face challenges due to donor variability and lack of scalability, highlighting the need for new, improved methods.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Oncology

CXCL9 inhibits tumour growth and drives anti-PD-L1 therapy in ovarian cancer

Stefanie Seitz et al.

Summary: CXCL9 acts as a driver of successful immune checkpoint blockade in ovarian cancer, and has potential as a predictive biomarker. Patients with clear-cell subtype display higher CXCL9 expression.

BRITISH JOURNAL OF CANCER (2022)

Article Chemistry, Multidisciplinary

Hydrolytically Degradable Microgels with Tunable Mechanical Properties Modulate the Host Immune Response

Maria M. Coronel et al.

Summary: This study demonstrates a facile method to synthesize microgels crosslinked with ester-containing junctions and investigates the effect of microgel degradability on in vivo tissue responses. The injectable microgels show time-dependent degradation in vivo and have the potential to modulate host tissue immune responses.
Article Engineering, Biomedical

Cartilage tissue engineering by extrusion bioprinting utilizing porous hyaluronic acid microgel bioinks

Killian Flegeau et al.

Summary: This study evaluated the ability of enzymatically crosslinked hyaluronic acid (HA) microgel bioinks to form mature cartilage in vivo, with promising results achieved through mechanically sizing bulk HA-tyramine hydrogels through meshes of different aperture diameters to form the microgel bioinks.

BIOFABRICATION (2022)

Article Multidisciplinary Sciences

Building block properties govern granular hydrogel mechanics through contact deformations

Dilara Borte Emiroglu et al.

Summary: This study investigates the relationship between the macroscopic properties of granular hydrogels and the features of their microgel building blocks using contact mechanics. By studying the mechanics of the microgel packings and modeling the system as a collection of two-body interactions, the researchers were able to accurately describe the rheological properties of the granular hydrogels. These findings provide a rational design framework for improving the engineering of this fascinating class of materials.

SCIENCE ADVANCES (2022)

Review Chemistry, Multidisciplinary

Recent Advances in Microgels: From Biomolecules to Functionality

Yufan Xu et al.

Summary: This review discusses the applications and potential of microgels in various fields, including biomedical research, materials science, and bioengineering. The synthesis of microgels using microfluidic technologies is a key enabling technology for tailoring their properties. Microgels play important roles in liquid-liquid phase separation, micromechanics, biosensors, and regenerative medicine.
Article Immunology

CXCL9 secreted by tumor-associated dendritic cells up-regulates PD-L1 expression in bladder cancer cells by activating the CXCR3 signaling

Weigang Xiu et al.

Summary: TADCs produce high levels of CXCL9 to increase PD-L1 expression in bladder cancer T24 cells, inhibiting anti-tumor T cell responses and promoting tumor growth.

BMC IMMUNOLOGY (2021)

Review Allergy

IL-25 (IL-17E) in epithelial immunology and pathophysiology

Julia Borowczyk et al.

Summary: IL-25, a unique cytokine of the IL-17 family, predominantly derived from epithelial cells, plays a significant role in various organ systems' physiology and pathology. It may lead to inflammatory disorders and helps maintain the balance in regulating immune responses.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis

Qichan Hu et al.

Summary: MMP-13 is an attractive target for the treatment of OA due to its involvement in cartilage degradation through cleaving type II collagen. However, there are currently no interventions available to restore degraded cartilage in OA.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Polymer Science

Facile Synthesis of Rapidly Degrading PEG-Based Thiol-Norbornene Hydrogels

Fang-Yi Lin et al.

Summary: The newly developed PEGNBCA material has comparable photo-cross-linking kinetics to traditional PEGNB in hydrogels, and provides an additional conjugation group, but is highly susceptible to hydrolytic degradation.

ACS MACRO LETTERS (2021)

Article Materials Science, Biomaterials

Microfluidics generation of chitosan microgels containing glycerylphytate crosslinker for in situ human mesenchymal stem cells encapsulation

Ana Mora-Boza et al.

Summary: Human mesenchymal stem cells (hMSCs) are encapsulated in microcarriers fabricated through microfluidics, showing improved cell viability and reparative activities.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Review Nanoscience & Nanotechnology

Hydrogel microparticles for biomedical applications

Andrew C. Daly et al.

NATURE REVIEWS MATERIALS (2020)

Article Engineering, Biomedical

Linkage Groups within Thiol-Ene Photoclickable PEG Hydrogels Control In Vivo Stability

Michael D. Hunckler et al.

ADVANCED HEALTHCARE MATERIALS (2019)

Article Engineering, Biomedical

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

Sasan Jalili-Firoozinezhad et al.

NATURE BIOMEDICAL ENGINEERING (2019)

Article Chemistry, Multidisciplinary

Enhanced In Vivo Delivery of Stem Cells using Microporous Annealed Particle Scaffolds

Jaekyung Koh et al.

Article Materials Science, Biomaterials

Clickable PEG hydrogel microspheres as building blocks for 3D bioprinting

Shangjing Xin et al.

BIOMATERIALS SCIENCE (2019)

Review Cell & Tissue Engineering

Mesenchymal stem cell perspective: cell biology to clinical progress

Mark F. Pittenger et al.

NPJ REGENERATIVE MEDICINE (2019)

Article Oncology

CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer

Chenlu Zhang et al.

BMC CANCER (2018)

Article Pharmacology & Pharmacy

Fabrication of antibody-loaded microgels using microfluidics and thiol-ene photoclick chemistry

Manuel Gregoritza et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018)

Article Engineering, Biomedical

Assembly of PEG Microgels into Porous Cell-Instructive 3D Scaffolds via Thiol-Ene Click Chemistry

Shangjing Xin et al.

ADVANCED HEALTHCARE MATERIALS (2018)

Article Nanoscience & Nanotechnology

Parallel droplet microfluidics for high throughput cell encapsulation and synthetic microgel generation

Devon M. Headen et al.

MICROSYSTEMS & NANOENGINEERING (2018)

Article Materials Science, Biomaterials

A microfluidic-based cell encapsulation platform to achieve high long-term cell viability in photopolymerized PEGNB hydrogel microspheres

Zhongliang Jiang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

Article Nanoscience & Nanotechnology

Microfluidic Encapsulation of Human Mesenchymal Stem Cells for Articular Cartilage Tissue Regeneration

Fanyi Li et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Article Engineering, Biomedical

Protease-degradable microgels for protein delivery for vascularization

Greg A. Foster et al.

BIOMATERIALS (2017)

Review Polymer Science

Thiol-Norbornene Photoclick Hydrogels for Tissue Engineering Applications

Chien-Chi Lin et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2015)

Article Polymer Science

PEG-Based Microgels Formed by Visible-Light-Mediated Thiol-Ene Photo-Click Reactions

Andrew K. Fraser et al.

MACROMOLECULAR CHEMISTRY AND PHYSICS (2014)

Review Biochemical Research Methods

Surfactants in droplet-based microfluidics

Jean-Christophe Baret

LAB ON A CHIP (2012)

Article Engineering, Biomedical

The effect of photopolymerization on stem cells embedded in hydrogels

Natalja E. Fedorovich et al.

BIOMATERIALS (2009)