期刊
ADVANCED HEALTHCARE MATERIALS
卷 12, 期 15, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202202794
关键词
gold nanorods; lipopolysaccharide aptamers; MoS2 nanosheets; multidrug-resistant Pseudomonas aeruginosa; targeted photothermal therapy; wound healing
Chronic wounds infected by multidrug-resistant gram-negative bacteria pose a global public health threat. This study presents a selective therapeutic nanorod (MoS2-AuNRs-apt) that targets lipopolysaccharide (LPS) on the surface of bacteria. The nanorod combines excellent photothermal conversion efficiency with enhanced biocompatibility and active targeting. It effectively reduces inflammation and accelerates wound healing in MRPA-infected wounds.
Chronic wounds infected by multidrug-resistant gram-negative bacteria have evolved resistance to traditional antibiotic therapy, posing a threat to global public health in recent years. Herein, a selective therapeutic nanorod (MoS2-AuNRs-apt) based on molybdenum disulfide (MoS2) nanosheets coated gold nanorods (AuNRs) targeting lipopolysaccharide (LPS) is presented. AuNRs have excellent photothermal conversion efficiency in 808 nm laser-guided photothermal therapy (PTT), and the MoS2 nanosheets coating significantly enhances the biocompatibility of AuNRs. Furthermore, the conjugation of the nanorods with aptamer permits active targeting of LPS on the surface of gram-negative bacteria and a specific anti-inflammatory ability in the multidrug-resistant Pseudomonas aeruginosa (MRPA)-infected wound murine model. It is concluded that the antimicrobial effect of these nanorods is considerably more significant than non-targeted PTT. Moreover, they can precisely overcome MRPA bacteria by physical damage and effectively reduce excess M1 inflammatory macrophages to accelerate the healing of infected wounds. Overall, this molecular therapeutic strategy displays great potential as a prospective antimicrobial treatment for MRPA infections.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据