4.7 Article

Direct Utilization of Peroxisomal Acetyl-CoA for the Synthesis of Polyketide Compounds in Saccharomyces cerevisiae

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biotechnology & Applied Microbiology

Metabolic engineering of oleaginous yeast Rhodotorula toruloides for overproduction of triacetic acid lactone

Mingfeng Cao et al.

Summary: This study demonstrates the metabolic engineering of Rhodotorula toruloides to achieve high production of the plant-sourced polyketide triacetic acid lactone (TAL). By introducing relevant genes and optimizing metabolic pathways, TAL production was significantly increased. The findings highlight the potential of Rhodotorula toruloides as a host for the production of TAL and other polyketides from low-cost carbon sources.

BIOTECHNOLOGY AND BIOENGINEERING (2022)

Article Multidisciplinary Sciences

Enhanced production of acetyl-CoA-based products via peroxisomal surface display in Saccharomyces cerevisiae

Hannah C. Yocum et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Biochemistry & Molecular Biology

Peroxisome compartmentalization of a toxic enzyme improves alkaloid production

Parbir S. Grewal et al.

Summary: This study demonstrates that by targeting the toxic enzyme NCS to the peroxisome and enlarging peroxisomes through the expression of engineered transcription factors, the production of (S)-reticuline and other alkaloids can be increased efficiently.

NATURE CHEMICAL BIOLOGY (2021)

Review Biotechnology & Applied Microbiology

Recent progress in metabolic engineering of Saccharomyces cerevisiae for the production of malonyl-CoA derivatives

Shiyun Li et al.

Summary: In order to reduce reliance on petroleum, utilizing industrial microorganisms for the biosynthesis of important chemicals from simple substrates has become a focus of interest. This review explores strategies to increase intracellular malonyl-CoA levels and advances in metabolic engineering for directing malonyl-CoA to desired derivatives, including strengthening supply, reducing consumption, and controlling levels effectively. These strategies offer new insights for enhancing malonyl-CoA derivative synthesis in microorganisms.

JOURNAL OF BIOTECHNOLOGY (2021)

Article Multidisciplinary Sciences

Complete and efficient conversion of plant cell wall hemicellulose into high-value bioproducts by engineered yeast

Liang Sun et al.

Summary: The authors successfully engineered Baker's yeast to co-consume xylose and acetate for triacetic acid lactone production. This metabolic re-configuration boosted the synthesis of valuable bioproducts such as TAL.

NATURE COMMUNICATIONS (2021)

Review Biotechnology & Applied Microbiology

Engineering intracellular malonyl-CoA availability in microbial hosts and its impact on polyketide and fatty acid synthesis

Lars Milke et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Article Biotechnology & Applied Microbiology

Developing a broad-range promoter set for metabolic engineering in the thermotolerant yeast Kluyveromyces marxianus

Xuye Lang et al.

METABOLIC ENGINEERING COMMUNICATIONS (2020)

Review Biotechnology & Applied Microbiology

Harnessing sub-organelle metabolism for biosynthesis of isoprenoids in yeast

Xuan Cao et al.

SYNTHETIC AND SYSTEMS BIOTECHNOLOGY (2020)

Article Biotechnology & Applied Microbiology

Leveraging host metabolism for bisdemethoxycurcumin production in Pseudomonas putida

Matthew R. Incha et al.

METABOLIC ENGINEERING COMMUNICATIONS (2020)

Article Biotechnology & Applied Microbiology

Synthesis of polyketides from low cost substrates by the thermotolerant yeast Kluyveromyces marxianus

Tami L. McTaggart et al.

BIOTECHNOLOGY AND BIOENGINEERING (2019)

Review Chemistry, Multidisciplinary

Evolution and Diversity of Assembly-Line Polyketide Synthases

Aleksandra Nivina et al.

CHEMICAL REVIEWS (2019)

Article Multidisciplinary Sciences

Rewiring Yarrowia lipolytica toward triacetic acid lactone for materials generation

Kelly A. Markham et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

Reprogramming Yeast Metabolism from Alcoholic Fermentation to Lipogenesis

Tao Yu et al.

Article Biochemistry & Molecular Biology

Yeast peroxisomes: How are they formed and how do they grow?

Arman Aksit et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

Article Biotechnology & Applied Microbiology

Engineering Escherichia coli to increase triacetic acid lactone (TAL) production using an optimized TAL sensor-reporter system

Ye Li et al.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2018)

Review Biochemistry & Molecular Biology

The architectures of iterative type I PKS and FAS

Dominik A. Herbst et al.

NATURAL PRODUCT REPORTS (2018)

Article Multidisciplinary Sciences

Repurposing type III polyketide synthase as a malonyl-CoA biosensor for metabolic engineering in bacteria

Dongsoo Yan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Biochemistry & Molecular Biology

Type III Polyketide Synthases: Functional Classification and Phylogenomics

Yugo Shimizu et al.

CHEMBIOCHEM (2017)

Article Cell Biology

Pex35 is a regulator of peroxisome abundance

Ido Yofe et al.

JOURNAL OF CELL SCIENCE (2017)

Article Biochemistry & Molecular Biology

Harnessing yeast organelles for metabolic engineering

Sarah K. Hammer et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Genetics & Heredity

Saccharomyces cerevisiae as a tool for mining, studying and engineering fungal polyketide synthases

Carly Bond et al.

FUNGAL GENETICS AND BIOLOGY (2016)

Article Biotechnology & Applied Microbiology

Engineering cofactor and transport mechanisms in Saccharomyces cerevisiae for enhanced acetyl-CoA and polyketide biosynthesis

Javier Cardenas et al.

METABOLIC ENGINEERING (2016)

Article Multidisciplinary Sciences

Towards repurposing the yeast peroxisome for compartmentalizing heterologous metabolic pathways

William C. DeLoache et al.

NATURE COMMUNICATIONS (2016)

Review Biotechnology & Applied Microbiology

Microbial acetyl-CoA metabolism and metabolic engineering

Anastasia Krivoruchko et al.

METABOLIC ENGINEERING (2015)

Article Biotechnology & Applied Microbiology

Overproduction of Fatty Acids in Engineered Saccharomyces cerevisiae

Xiaowei Li et al.

BIOTECHNOLOGY AND BIOENGINEERING (2014)

Article Biotechnology & Applied Microbiology

Improving polyketide and fatty acid synthesis by engineering of the yeast acetyl-CoA carboxylase

Jin Wook Choi et al.

JOURNAL OF BIOTECHNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Metabolic engineering of Saccharomyces cerevisiae for the production of triacetic acid lactone

Javier Cardenas et al.

METABOLIC ENGINEERING (2014)

Article Chemistry, Multidisciplinary

Screening for Enhanced Triacetic Acid Lactone Production by Recombinant Escherichia coli Expressing a Designed Triacetic Acid Lactone Reporter

Shuang-Yan Tang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Review Physiology

Import of proteins into the peroxisomal matrix

Sohel Hasan et al.

FRONTIERS IN PHYSIOLOGY (2013)

Article Chemistry, Multidisciplinary

Triacetic acid lactone as a potential biorenewable platform chemical

Mei Chia et al.

GREEN CHEMISTRY (2012)

Article Chemistry, Organic

Navigating the Fungal Polyketide Chemical Space: From Genes to Molecules

Yit-Heng Chooi et al.

JOURNAL OF ORGANIC CHEMISTRY (2012)

Review Biochemistry & Molecular Biology

The structures of type I polyketide synthases

Adrian T. Keatinge-Clay

NATURAL PRODUCT REPORTS (2012)

Review Cell Biology

Peroxisome assembly: matrix and membrane protein biogenesis

Changle Ma et al.

JOURNAL OF CELL BIOLOGY (2011)

Review Microbiology

Fatty acid biosynthesis in actinomycetes

Gabriela Gago et al.

FEMS MICROBIOLOGY REVIEWS (2011)

Article Biochemistry & Molecular Biology

Snf1 Dependence of Peroxisomal Gene Expression Is Mediated by Adr1

Sooraj Ratnakumar et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Review Microbiology

New insights into the formation of fungal aromatic polyketides

Jason M. Crawford et al.

NATURE REVIEWS MICROBIOLOGY (2010)

Review Chemistry, Multidisciplinary

The Biosynthetic Logic of Polyketide Diversity

Christian Hertweck

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

Review Biochemistry & Molecular Biology

The type I fatty acid and polyketide synthases: a tale of two megasynthases

Stuart Smith et al.

NATURAL PRODUCT REPORTS (2007)

Review Biochemistry & Molecular Biology

Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork

Christian Hertweck et al.

NATURAL PRODUCT REPORTS (2007)

Review Biochemistry & Molecular Biology

Fatty acid synthesis and elongation in yeast

Oksana Tehlivets et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2007)

Review Biochemistry & Molecular Biology

Uniqueness of the mechanism of protein import into the peroxisome matrix:: Transport of folded, co-factor-bound and oligomeric proteins by shuttling receptors

Sebastien Leon et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2006)

Review Microbiology

Biosynthesis of polyketides in heterologous hosts

BA Pfeifer et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2001)

Review Biochemistry & Molecular Biology

Polyketide biosynthesis: a millennium review

J Staunton et al.

NATURAL PRODUCT REPORTS (2001)