4.5 Article

PCR investigation of infections in patients consulting at a healthcare centre over a four-year period during the Grand Magal of Touba

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ELSEVIER SCI LTD
DOI: 10.1016/j.tmaid.2022.102515

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Febrile systemic illness; Gastrointestinal infections; Grand Magal; Patients; PCR; Respiratory infections

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Respiratory and gastrointestinal symptoms, as well as febrile illness, are common complaints among pilgrims at the Grand Magal of Touba in Senegal. Testing of samples revealed high rates of viral and bacterial infections, including influenza viruses, Haemophilus influenzae, and Entero-pathogenic Escherichia coli. The study also identified Plasmodium falciparum, Borrelia sp., and dengue virus as causes of fever. This research provides valuable insights for therapeutic options.
Background: Respiratory and gastrointestinal symptoms and febrile illness are the most common complaints among ill pilgrims attending the Grand Magal of Touba (GMT) in Senegal.Methods: Patients presenting with respiratory or gastrointestinal symptoms or febrile systemic illnesses were recruited between 2018 and 2021 at a healthcare centre close to Touba. Respiratory, gastrointestinal and blood samples were tested for potential pathogens using qPCR.Results: 538 patients were included. 45.5% of these were female, with a median age of 17 years. Of the 326 samples collected from patients with a cough, 62.8% tested positive for at least one virus, including influenza viruses (33.1%). A high positivity rate of bacterial carriage was observed for Haemophilus influenzae (72.7%), Streptococcus pneumoniae (51.2%) and Moraxella catarrhalis (46.0%). Of the 95 samples collected from patients with diarrhoea, 71.3% were positive, with high rates of bacterial carriage, ranging from 4.2% for Tropheryma whipplei to 45.3% for Entero-pathogenic Escherichia coli. Of the 141 blood samples collected from patients with fever, 31.9% were positive including Plasmodium falciparum (21.3%), Borrelia sp. (5.7%) and dengue virus (5.0%).Conclusion: This study provides insight into the aetiology of most common infections at the GMT on which to base therapeutic options.

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