Engineering of MSCs sheet for the prevention of myocardial ischemia and for left ventricle remodeling

Tissue engineering combines cell biology and material science to construct tissues or organs for disease modeling, drug testing, and regenerative medicine. The cell sheet is a newly developed tissue engineering technology that has brought about scaffold-free tissue and shows great application potential. In this review, we summarized recent progress and future possibilities in preclinical research into and clinical applications of cell sheets fabricated by differing cell types from various sources for cardiac tissue repair, and the manufacturing strategies and promising application potential of 3D cell-dense tissue constructed from cell sheets. Special attention was paid to the mechanisms of mesenchymal stem cell (MSC) sheets in the prevention of myocardial ischemia and left ventricle remodeling. Comparing MSCs sheets with other types of cell sheets and 3D cardiac tissues, engineering tissues' potential safety and effectiveness concerns were also discussed.

Automated summary

Tissue engineering combines cell biology and material science to construct tissues or organs for disease modeling, drug testing, and regenerative medicine. Cell sheet is a newly developed scaffold-free tissue engineering technology with great application potential. This review summarizes recent progress and future possibilities in preclinical research and clinical applications of cell sheets fabricated from different cell types for cardiac tissue repair, as well as the manufacturing strategies and promising application potential of 3D cell-dense tissue constructed from cell sheets. The mechanisms of mesenchymal stem cell (MSC) sheets in preventing myocardial ischemia and left ventricle remodeling are emphasized, and safety and effectiveness concerns of engineered tissues compared to other types of cell sheets and 3D cardiac tissues are discussed.