Computational study of blood flow inside MCA aneurysm with/without endovascular coiling

Article Computer Science, Interdisciplinary Applications

Computational analysis of the blood hemodynamic inside internal cerebral aneurysm in the existence of endovascular coiling

Asal Sadeh et al.

Summary: Blood hematocrit, porosity, and blood viscosity have significant impacts on the risk of aneurysm rupture, and computational fluid dynamic simulations are reliable tools for recognizing high-risk regions and assessing aneurysm status.

INTERNATIONAL JOURNAL OF MODERN PHYSICS C (2023)

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Article Engineering, Electrical & Electronic

Adaptive Finite-Time Command-Filtered Control for Switched Nonlinear Systems with Input Quantization and Output Constraints

Fabin Cheng et al.

Summary: This article considers the problem of finite-time command-filtered control for switched nonlinear systems with input quantization and output constraints. The unmeasurable state is estimated by designing a switched state observer. Hysteresis quantization and barrier Lyapunov function approach are used to solve the chattering problem and restrict the output to an expected range. A first-order Levant differentiator is used to accurately filter the intermediate signals and ensure the finite-time stability of the filter. Stability of the closed-loop system is proved using multiple Lyapunov functions.

CIRCUITS SYSTEMS AND SIGNAL PROCESSING (2023)

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Article Biophysics

Influence of stent-induced vessel deformation on hemodynamic feature of bloodstream inside ICA aneurysms

Amir Sabernaeemi et al.

Summary: The use of stent-assisted coiling for intracranial aneurysms may lead to the deformation of local vasculature. This study investigates the hemodynamic features of blood flow in four different types of intracranial aneurysms with and without stent intervention. The results show that stenting decreases blood velocity, wall pressure, and wall shear stress, while it has inconsistent effects on neck inflow rate among the aneurysms.

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2023)

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Article Engineering, Electrical & Electronic

A Practical Feeder Planning Model for Urban Distribution System

Mingqiang Wang et al.

Summary: There is a significant gap between academic research and practical application in power distribution system planning (PDSP). Existing PDSP models in academic research mainly focus on cost as the objective function and have constraints such as power flow equality, voltage limits, and capacity limits. However, these models are rarely used in real distribution system companies. This paper proposes a new feeder planning model for urban distribution networks, considering practical requirements such as load moment, block loads, street layout, network configuration, and the crossing requirement of feeders. The model is solved using mixed integer linear programming and is demonstrated on test and real distribution systems.

IEEE TRANSACTIONS ON POWER SYSTEMS (2023)

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Article Computer Science, Interdisciplinary Applications

Computational study of blood hemodynamic in ICA aneurysm with coiling embolism

Milad Mirzaei Poueinak et al.

Summary: The importance of blood flow characteristics in the hemorrhage of cerebral aneurysms has been confirmed. This study investigates the effects of blood hemodynamics on the growth and rupture of the Internal Carotid Intracranial (ICA) and demonstrates the blood features inside the ICA at different time stages. The study also examines the impact of coiling on blood characteristics. Computational Fluid Dynamics (CFD) is used to analyze the effects of blood hemodynamics on wall shear stress and pressure distribution within the aneurysm. The findings suggest that reducing coiling porosity can decrease maximum WSS and OSI, especially in high blood viscosity.

INTERNATIONAL JOURNAL OF MODERN PHYSICS C (2023)

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Article Engineering, Multidisciplinary

CFD investigations of the blood hemodynamic inside internal cerebral aneurysm (ICA) in the existence of coiling embolism

Zan -Hui Jin et al.

Summary: The coiling technique is the most significant and conventional option for treating an intracranial aneurysm. The effects of blood hemodynamics on the risk of aneurysm rupture are investigated through transient simulations of blood stream. The impacts of blood viscosity and coiling treatment on the distribution of WSS and OSI factors are comprehensively discussed.

ALEXANDRIA ENGINEERING JOURNAL (2023)

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Article Clinical Neurology

Effects of blood hematocrit on performance of endovascular coiling for treatment of middle cerebral artery (MCA) aneurysms: Computational study

Saman Hariri et al.

Summary: This study used computational fluid dynamics to simulate the blood flow in cerebral aneurysms treated with coiling embolism. The results showed that the wall shear stress (WSS) was highest near the neck of the aneurysm, while the oscillatory shear index (OSI) was highest near the dome of the aneurysm. Coiling reduced the OSI but had limited impact on the WSS near the neck.

INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT (2023)

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Article Multidisciplinary Sciences

Computational study of the blood hemodynamic inside the cerebral double dome aneurysm filling with endovascular coiling

Ali Rostamian et al.

Summary: This study investigates the impact of coiling technique on the progression and rupture risk of intracranial cerebral aneurysms (ICA) using computational fluid dynamics. The study reveals that changes in hematocrit concentration have a significant effect on maximum wall shear stress. Additionally, reducing porosity leads to a decrease in maximum wall shear stress.

SCIENTIFIC REPORTS (2023)

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Article Mathematics, Applied

Logistic damping effect in chemotaxis models with density-suppressed motility

Wenbin Lyu et al.

Summary: This paper investigates a parabolic-elliptic chemotaxis model with density-suppressed motility and general logistic source in an n-dimensional smooth bounded domain with Neumann boundary conditions. The main focus is on exploring the strength of logistic damping necessary to ensure the global boundedness of solutions, and establishing the asymptotic behavior of solutions under certain conditions.

ADVANCES IN NONLINEAR ANALYSIS (2023)

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Article Computer Science, Interdisciplinary Applications

Numerical simulation of blood flow effects on rupture of aneurysm in middle cerebral artery

Xiao-Yong Shen et al.

Summary: This research used computational fluid dynamics to investigate the rupture and growth of intracranial aneurysms in the middle cerebral artery. The study revealed the significant influence of blood viscosity and velocity on the danger of aneurysm rupture, with outcomes showing the direct impact of aneurysm location and orientation on its growth.

INTERNATIONAL JOURNAL OF MODERN PHYSICS C (2022)

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Article Biochemistry & Molecular Biology

webTWAS: a resource for disease candidate susceptibility genes identified by transcriptome-wide association study

Chen Cao et al.

Summary: webTWAS is a new resource that combines comprehensive disease GWAS datasets with information on potential causal genes, allowing researchers to explore gene-disease associations. With data from 1298 high-quality GWAS summary statistics, a total of 235,064 gene-disease associations can be accessed, and custom TWAS analyses can be run on a user-friendly web server.

NUCLEIC ACIDS RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Oral colon-targeted mucoadhesive micelles with enzyme-responsive controlled release of curcumin for ulcerative colitis therapy

Chen Zhang et al.

Summary: In this study, colon-targeted nano-micelles with mucoadhesive effect and Azo reductase-triggered drug release profiles were developed for the delivery of curcumin in the treatment of ulcerative colitis. The curcumin-loaded micelles exhibited Azo reductase-sensitive particle dissociation and drug release, enhanced cellular uptake, and prolonged retention on colonic mucosa due to the strong mucoadhesion of catechol structure.

CHINESE CHEMICAL LETTERS (2022)

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Article Computer Science, Interdisciplinary Applications

Numerical study of droplet breakup in an asymmetric T-junction microchannel with different cross-section ratios

Milad Isanejad et al.

Summary: In this study, numerical simulations are performed to investigate droplet breakup in an asymmetric T-junction microchannel. The results show good agreement with previous studies, and the effects of capillary number, non-dimensional droplet length, and non-dimensional width ratio on the breakup time and splitting ratio are studied. It is also found that the mass center of the mother droplet is shifted to a wider branch, facilitating the asymmetric breakup in the T-junction microchannel.

INTERNATIONAL JOURNAL OF MODERN PHYSICS C (2022)

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Article Automation & Control Systems

Command filter-based adaptive neural finite-time control for stochastic nonlinear systems with time-varying full-state constraints and asymmetric input saturation

Yulin Li et al.

Summary: This article proposes an adaptive neural finite-time control strategy for stochastic nonlinear systems, which combines neural network approximation and backstepping technique, constructs a time-varying barrier Lyapunov function, and solves the difficulty arising from saturation nonlinearity. With the proposed control strategy, it is guaranteed that system signals are bounded, the reference signal is tracked within a finite time, and system states do not violate constraints.

INTERNATIONAL JOURNAL OF SYSTEMS SCIENCE (2022)

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Article Engineering, Mechanical

Study on the effect of raindrops on the dynamic stall of a NACA-0012 airfoil

Armin Sheidani et al.

Summary: In this study, the pure effect of raindrops on dynamic stall of a pitching airfoil has been investigated. It was found that raindrops have negative effects on the lift coefficient of the pitching airfoil, and the presence of raindrops leads to the advancement of some aerodynamic phenomena.

JOURNAL OF THE BRAZILIAN SOCIETY OF MECHANICAL SCIENCES AND ENGINEERING (2022)

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Article Multidisciplinary Sciences

Splitting of droplet with different sizes inside a symmetric T-junction microchannel using an electric field

Keivan Fallah et al.

Summary: In this study, droplets dynamics under an asymmetric electric field in a T-junction were numerically investigated, and two novel droplet patterns were observed. It was concluded that using an electric field allows for precise control over droplet size and splitting ratio.

SCIENTIFIC REPORTS (2022)

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Article Pharmacology & Pharmacy

Gli1 promotes epithelial-mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating snail transcriptional activity and stability

Xueping Lei et al.

Summary: Gli1 promotes the metastasis of non-small cell lung carcinoma and is associated with poor patient survival.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Multidisciplinary Sciences

Influence of the coiling porosity on the risk reduction of the cerebral aneurysm rupture: computational study

Armin Sheidani et al.

Summary: This study comprehensively investigates the effects of blood hemodynamics on the creation and growth of internal carotid artery aneurysms using computational fluid dynamics. The study compares OSI and WSS of the aneurysm wall at different blood flow stages and explores the impact of blood viscosity and coiling treatment on these factors.

SCIENTIFIC REPORTS (2022)

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Article Multidisciplinary Sciences

FIVES: A Fundus Image Dataset for Artificial Intelligence based Vessel Segmentation

Kai Jin et al.

Summary: In this study, a color fundus image vessel segmentation dataset was collected, which is believed to be beneficial for the further development of retinal vessel segmentation.

SCIENTIFIC DATA (2022)

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Article Pediatrics

Beneficial Effects of Repeated Washed Microbiota Transplantation in Children With Autism

Zhao-Yu Pan et al.

Summary: This study retrospectively evaluated the efficacy of repeated washed microbiota transplantation (WMT) in children with autism spectrum disorder (ASD). The results showed that WMT significantly improved ASD symptoms, sleep disorders, and gastrointestinal symptoms, as well as reduced systemic inflammation. Additional WMT courses led to more obvious improvements in ASD symptoms.

FRONTIERS IN PEDIATRICS (2022)

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Article Automation & Control Systems

Adaptive command filtered control for switched multi-input multi-output nonlinear systems with hysteresis inputs

Yuanqing Wang et al.

Summary: This article presents an adaptive command filtered control scheme for a class of multiple-input multiple-output switched nonlinear systems with backlash-like hysteresis. By using command filter technique and error compensation mechanism, the proposed controller overcomes the complexity issue and design difficulty caused by system nonlinearity. Simulation results demonstrate the effectiveness of the scheme in ensuring system outputs track desired trajectories while keeping all signals bounded.

INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING (2022)

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Article Engineering, Civil

Performance of different inflow turbulence methods for wind engineering applications

Zahra Mansouri et al.

Summary: Defining the correct inlet boundary conditions is crucial in computational wind engineering, and synthetic inflow turbulence is a preferable approach due to its cost-effectiveness. This study investigates different synthetic turbulence generator methods and evaluates their performance in wind engineering applications. The results show that most methods produce spurious pressure, except for the Synthetic Eddy Method with the Gaussian shape function (SEM-G), which is found to be suitable for peak pressure prediction with a maximum error of 30%.

JOURNAL OF WIND ENGINEERING AND INDUSTRIAL AERODYNAMICS (2022)

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Article Endocrinology & Metabolism

The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages

Zhaolan Hu et al.

Summary: Hu and Zhao et al. have discovered a mechanism by which tissue macrophages in autoimmune diseases adapt to nutrient stress. This mechanism involves the cytokine CCL18 and the transcription factor RFX5, which regulate metabolic adaptation and antigen-presenting function in tissue inflammation.

NATURE METABOLISM (2022)

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Article Energy & Fuels

Photovoltaic power forecast based on satellite images considering effects of solar position

Zhiyuan Si et al.

Summary: This paper proposes a novel method based on satellite images to accurately forecast photovoltaic power by predicting cloud movement and dynamically selecting cloud regions. By utilizing the XGBoost algorithm and considering multiple factors, the accuracy of the forecast can be improved, as demonstrated through testing the effectiveness of the method compared to other benchmarks.

APPLIED ENERGY (2021)

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Article Engineering, Aerospace

Multi-physics simulation of an insect with flapping wings

Kabir Bakhshaei et al.

Summary: This paper investigates the unsteady aerodynamics of an insect's forward flight using a novel approach. By combining multiple software to interact with each other at each time step, the most accurate way for conducting precise multi-physics simulations has been identified.

PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART G-JOURNAL OF AEROSPACE ENGINEERING (2021)

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Article Green & Sustainable Science & Technology

Confidence Interval Based Distributionally Robust Real-Time Economic Dispatch Approach Considering Wind Power Accommodation Risk

Peng Li et al.

Summary: This article introduces a confidence interval based distributionally robust real-time economic dispatch (CI-DRED) approach, which addresses the risk associated with accommodating wind power. By developing a novel ambiguity set based on imprecise probability theory and transforming the original nonlinear dispatch problem into a determined mixed integer linear programming problem, the proposed method effectively balances operational costs and risks. Numerical results on both the IEEE 118-bus system and a real 445-bus system demonstrate the efficiency and effectiveness of the approach.

IEEE TRANSACTIONS ON SUSTAINABLE ENERGY (2021)

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Article Cell Biology

Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation

Xuan Zhang et al.

Summary: Elevated homocysteine levels are associated with insulin resistance, which is induced by homocysteinylation of the pro-insulin receptor. Homocysteine reacts with and modifies cysteine-825 of pro-IR in the ER, disrupting the original disulfide bond. This modification impairs the interaction between pro-IR and Furin protease in the Golgi apparatus, hindering cleavage of pro-IR and leading to insulin resistance in mice. Inhibiting homocysteinylation could potentially be a new target for drugs to prevent insulin resistance and increase insulin sensitivity.

CELL REPORTS (2021)

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Article Physics, Multidisciplinary

Computational study of blood flow characteristics on formation of the aneurysm in internal carotid artery

Xiao-Yong Shen et al.

Summary: The study utilized computational simulations to uncover the effects of blood flow characteristics on the evolution and rupture of aneurysms in the internal carotid artery. The research aimed to identify the main causes for aneurysm rupture and pinpoint high-risk regions on the aneurysm wall. Findings suggest that aneurysm growth is directly related to its orientation and location, with internal wall shear stress being significantly lower than external stress.

EUROPEAN PHYSICAL JOURNAL PLUS (2021)

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Article Computer Science, Information Systems

Sliding-mode surface-based adaptive actor-critic optimal control for switched nonlinear systems with average dwell time

Haoyan Zhang et al.

Summary: This paper studies adaptive optimal control based on sliding-mode surface (SMS) for a class of continuous-time switched nonlinear systems with average dwell time (ADT) using actor-critic reinforcement learning strategy. By developing a specific cost function related to SMS, the original control problem is transformed into finding a series of optimal control policies through AC neural networks. The proposed method is shown to ensure the boundedness of all signals in the considered closed-loop switched nonlinear systems through Lyapunov stability theory.

INFORMATION SCIENCES (2021)

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Article Computer Science, Interdisciplinary Applications

Effects of blood flow characteristics on rupture of cerebral aneurysm: Computational study

Xiao-Yong Shen et al.

Summary: Cardiovascular disease and stroke have been identified as the leading causes of high death rates in recent decades, with irregular blood flow being a major factor. The study reveals that blood viscosity and velocity have a significant impact on the blood flow inside an aneurysm, with high velocity and viscosity increasing the risk of aneurysm rupture.

INTERNATIONAL JOURNAL OF MODERN PHYSICS C (2021)

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Article Pharmacology & Pharmacy