Neuroprotective and antioxidant properties of new quinolylnitrones in in vitro and in vivo cerebral ischemia models

Article Pharmacology & Pharmacy

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

Damijan Knez et al.

Summary: This study describes the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases and monoamine oxidases for the therapy of neurodegenerative diseases.

ACTA PHARMACEUTICA SINICA B (2023)

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Article Neurosciences

EPA-enriched plasmalogen attenuates the cytotoxic effects of LPS-stimulated microglia on the SH-SY5Y neuronal cell line

Tian-Xin Yang et al.

Summary: The study provides evidence for the positive effect of PlsEtn on neuroprotection and neuroinflammation inhibition, and PlsEtn may be explored as a potential functional ingredient.

BRAIN RESEARCH BULLETIN (2022)

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Article Biochemistry & Molecular Biology

Postischemic Neuroprotection of Aminoethoxydiphenyl Borate Associates Shortening of Peri-Infarct Depolarizations

Rocio Fernandez-Serra et al.

Summary: Brain stroke is a common pathology that causes disability in older adults. Previous neuroprotective treatments have not been effectively translated into clinical practice, highlighting the need for novel targets. This study demonstrates the neuroprotective properties of 2-APB and its ability to improve cerebral blood perfusion by targeting spreading depolarization events in ischemic stroke.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities

Zofia Chrienova et al.

Summary: Twenty-four novel compounds with tetrahydroacridine and N-propargyl moieties were designed, synthesized, and evaluated for their anti-cholinesterase and anti-monoamine oxidase activities in vitro. Compounds 7, 15, 20, 21, 23, and 25 exhibited the most balanced pharmacological profile, with compound 15 identified as a permeable agent with promising therapeutic potential.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2022)

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Article Chemistry, Medicinal

Privileged Quinolylnitrones for the Combined Therapy of Ischemic Stroke and Alzheimer's Disease

Jose M. Alonso et al.

Summary: The article discusses the relationship between cerebrovascular diseases and dementia caused by Alzheimer's disease, highlighting the importance of developing new dual therapeutic agents. A new small quinolylnitrone, MC903, is proposed as a potential dual therapy for stroke and Alzheimer's disease.

PHARMACEUTICALS (2021)

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Review Biochemistry & Molecular Biology