TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1/MEK/ERK signalling pathway

Article Oncology

FET fusion oncoproteins interact with BRD4 and SWI/SNF chromatin remodelling complex subtypes in sarcoma

Malin Linden et al.

Summary: FET fusion oncoproteins bind with SWI/SNF complexes and indirectly interact with BRD4, co-localizing on chromatin and interacting with transcription factors and RNA Polymerase II.

MOLECULAR ONCOLOGY (2022)

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Article Oncology

Histidine-rich calcium binding protein promotes gastric cancer cell proliferation, migration, invasion and epithelial-mesenchymal transition through Raf/MEK/ERK signaling

Chao Wang et al.

Summary: This study reveals that the expression of HRC is upregulated in human gastric cancer and correlates with patient prognosis and tumor aggressiveness. Overexpression of HRC promotes gastric cancer cell proliferation and migration, while knockdown of HRC inhibits tumor growth and invasion. HRC may regulate the epithelial-mesenchymal transition of gastric cancer through the Ca2+/CaM signaling pathway.

JOURNAL OF CANCER (2022)

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Article Oncology

RAF-MEK-ERK pathway in cancer evolution and treatment

Rahim Ullah et al.

Summary: The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway that plays a critical role in cell proliferation and survival. Genetic alterations in this pathway are highly prevalent in human cancers and can lead to uncontrolled cell growth and tumor formation. The crosstalk between the RAF-MEK-ERK axis and other signaling pathways further enhances its proliferative potential in human cancers.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Biotechnology & Applied Microbiology

LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway

Huaiyang Zhu et al.

Summary: This study revealed the role of the E2F7/LINC00649/TAF15/MAPK6/MAPK signaling pathway in regulating LUSC development and identified LINC00649 as a potential biomarker for LUSC treatment.

CANCER GENE THERAPY (2022)

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Article Pathology

LncRNA MIR9-3HG enhances LIMK1 mRNA and protein levels to contribute to the carcinogenesis of lung squamous cell carcinoma via sponging miR-138-5p and recruiting TAF15

Yu Xiong et al.

Summary: The overexpression of MIR9-3HG is closely associated with the malignant progression of lung squamous cell carcinoma (LUSC). MIR9-3HG regulates the expression levels of LIM domain kinase 1 (LIMK1) by interacting with miR-138-5p and TATA-box binding protein associated factor 15 (TAF15), thereby promoting LUSC carcinogenesis.

PATHOLOGY RESEARCH AND PRACTICE (2022)

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Article Biology

Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth

Elena Vasileva et al.

Summary: Ewing sarcoma is a malignant tumor that mainly affects children, adolescents, and young adults. The lack of a reliable genetic animal model has hindered the study of tumor cell and microenvironment interactions. By introducing human EWSR1-FLI1 gene into zebrafish, a new genetic model of Ewing sarcoma has been developed, which exhibits high penetrance and rapid tumor formation, providing a valuable tool for investigating the disease. Additionally, the study reveals the important role of the extracellular matrix in Ewing sarcoma tumor growth and suggests that targeting proteoglycan metabolism could be a potential novel therapy.

ELIFE (2022)

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Article Oncology

miR-2682-3p antagonizes its host lncRNA-MIR137HG by interacting with the same target FUS to regulate the progression of gastric cancer

Yantao Du et al.

Summary: This study found that lncRNA MIR137HG promotes growth and metastasis in gastric cancer by interacting with FUS. In contrast, miR-2682-3p antagonizes the function of MIR137HG by targeting FUS.

BMC CANCER (2022)

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Article Biochemistry & Molecular Biology

circVMA21 combining with TAF15 stabilizes SOCS3 mRNA to relieve septic lung injury through regulating NF-KB activation

Zi-Gui Zhu et al.

Summary: This study found that circVMA21 suppressed LPS-induced lung injury by mediating the TAF15/SOCS3/NF-KB axis, reducing inflammation and cell apoptosis, thereby improving sepsis-induced lung injury.

MOLECULAR IMMUNOLOGY (2022)

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Article Cell Biology

TIF1? inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex

Zhiyue Su et al.

Summary: This study reveals the molecular mechanisms underlying lung adenocarcinoma (LUAD) metastasis, highlighting the crucial role of the TAF15/TBP complex in promoting EMT and invasion of LUAD cells, which is inhibited by TIF1y.

CELL REPORTS (2022)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Multidisciplinary Sciences

Loci-specific phase separation of FET fusion oncoproteins promotes gene transcription

Linyu Zuo et al.

Summary: FUS/EWS/TAF15 (FET) fusion oncoproteins, containing low complexity domain, form biomolecular condensates that recruit RNA polymerase II, promoting gene transcription. Through the development of a single-molecule assay, a causal relationship between the formation of condensates on DNA and gene transcription is supported, along with the identification of a threshold number of fusion-binding DNA elements required for the formation of FET protein condensates.

NATURE COMMUNICATIONS (2021)

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Article Medicine, Research & Experimental

LncRNA GAS5 activates the HIF1A/VEGF pathway by binding to TAF15 to promote wound healing in diabetic foot ulcers

Wei-Xia Peng et al.

Summary: The study found that the long non-coding RNA GAS5 plays a crucial role in wound healing in diabetic foot ulcers (DFUs) by accelerating wound healing through activating the HIF1A/VEGF pathway. GAS5 interacts with TAF15 to facilitate the expression of HIF1A, contributing to its functions in DFUs.

LABORATORY INVESTIGATION (2021)

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Article Cell Biology

LncRNA APOA1-AS facilitates proliferation and migration and represses apoptosis of VSMCs through TAF15-mediated SMAD3 mRNA stabilization

Jixiang Wang et al.

Summary: This study investigated the role of APOA1-AS in coronary atherosclerosis, revealing that APOA1-AS promotes the proliferation and migration of VSMCs through TAF15-mediated SMAD3 mRNA stabilization while inhibiting apoptosis. This suggests that APOA1-AS may be a promising therapeutic target for CAS.

CELL CYCLE (2021)

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Article Biochemistry & Molecular Biology