The potential utility of the SAGIT instrument in the clinical assessment of patients with acromegaly, a large single-centre study

SAGIT is an instrument created for the clinical assessment of acromegaly. Our objective was to test the usefulness of this tool in assessing disease activity of acromegalic patients in a single centre of Poznan, Poland using a retrospective study. Medical records of patients with acromegaly hospitalised at the Department of Endocrinology, Metabolism and Internal Medicine of Poznan University of Medical Sciences in Poland between January 2015 and December 2020 were analysed. SAGIT scores were assessed according to each patient's clinical and biochemical data. The results show that SAGIT scores were higher in treatment-naive patients and the lowest in controlled patients. There were positive correlations between SAGIT scores and concentrations of calcium, phosphorus, HbA1C levels, and tumour invasiveness at the time of diagnosis. However, parameters such as age, vitamin D concentration, and time from diagnosis showed an inverse relationship with the SAGIT score. In ROC curve analysis, SAGIT scores of 5 or less discriminated controlled patients from uncontrolled (p < 0.0001, sensitivity 76.7%, specificity 78.5%, AUC 0.867). Also, SAGIT higher than 6 indicated for treatment start or escalation (p < 0.0001, sensitivity 80.88%, specificity 77.59%, AUC 0.866). Lack of signs and symptoms (S = 0) could not discriminate between controlled and uncontrolled disease, but predicted therapy maintenance (p < 0.0004, sensitivity 59.5%, specificity 58.2%, AUC 0.604). In conclusion, The SAGIT instrument is easy to use even when completed in the retrospective medical record review. It can be useful for distinguishing clinical stages of acromegaly and in decision-making.

Automated summary

The SAGIT tool was tested for its usefulness in assessing disease activity in acromegalic patients in a single centre in Poznan, Poland. The study found that SAGIT scores were higher in treatment-naive patients and the lowest in controlled patients. Positive correlations were observed between SAGIT scores and concentrations of calcium, phosphorus, HbA1C levels, and tumour invasiveness, while parameters such as age, vitamin D concentration, and time from diagnosis showed an inverse relationship with the SAGIT score. The SAGIT instrument is easy to use and can help distinguish clinical stages and aid in decision-making in acromegaly.