4.7 Article

Treatment with fibroblast growth factor 19 increases skeletal muscle fiber size, ameliorates metabolic perturbations and hepatic inflammation in 5/6 nephrectomized mice

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Fibroblast growth factor 15/19 expression, regulation, and function: An overview

Greg Guthrie et al.

Summary: This review summarizes the current literature on the protein FGF19, its target receptors, and the biological pathways they target through unique signaling cascades.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2022)

Article Physiology

Mineralocorticoid Receptor Antagonism Prevents the Synergistic Effect of Metabolic Challenge and Chronic Kidney Disease on Renal Fibrosis and Inflammation in Mice

Roberto Palacios-Ramirez et al.

Summary: Obesity and metabolic diseases are linked to chronic kidney disease, and mineralocorticoid receptor antagonists have shown potential in treating non-diabetic chronic kidney disease associated with metabolic diseases. This study used a mouse model to demonstrate the beneficial effects of the mineralocorticoid receptor antagonist canrenoate in improving metabolic function and reducing proteinuria in chronic kidney disease mice, while also preventing the detrimental effects of a high fat diet on renal fibrosis and inflammation.

FRONTIERS IN PHYSIOLOGY (2022)

Article Medicine, Research & Experimental

Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease

Trace Thome et al.

Summary: This study investigated the mechanisms of skeletal muscle mitochondrial impairment in mice with adenine-induced CKD. It found reductions in mitochondrial oxidative phosphorylation and identified unknown uremic metabolites associated with the degree of mitochondrial impairment. Additionally, CKD mice showed muscle atrophy, protein degradation, and morphological changes in the neuromuscular junction.

JCI INSIGHT (2021)

Article Cell Biology

FGF19 protects skeletal muscle against obesity-induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT-1/PGC-α pathway

Ai Guo et al.

Summary: The study demonstrates that FGF19 administration can improve muscle loss and physical dysfunction in obesity and sarcopenic obesity (SO), as well as promote energy expenditure and restore metabolic derangement. Additionally, FGF19 exerts protective effects on skeletal muscle partly through the AMPK/SIRT-1/PGC-alpha signaling pathway, suggesting its potential as a therapeutic target for obesity and SO.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Review Gastroenterology & Hepatology

The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer

Lulu Sun et al.

Summary: FXR plays a crucial role in metabolic diseases and gastrointestinal and liver cancers by regulating bile acid synthesis and enterohepatic circulation, influencing glucose and lipid homeostasis. Targeting FXR signaling and bile acid metabolites may provide potential strategies for prevention and treatment of gastrointestinal and liver cancers.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Multidisciplinary Sciences

A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease

Christophe Barba et al.

Summary: The low aromatic amino acid diet (LA-AAD) was found to be as effective as a low protein diet (LPD) in reducing the production of key uremic toxins, delaying the progression of chronic kidney disease with lower risk of malnutrition.

SCIENTIFIC REPORTS (2021)

Article Geriatrics & Gerontology

Fibroblast growth factor 19 as a countermeasure to muscle and locomotion dysfunctions in experimental cerebral palsy

Sabrina da Conceicao Pereira et al.

Summary: The study demonstrates that FGF19 treatment can help improve musculoskeletal and locomotor dysfunctions in an experimental rat model of CP. Administration of FGF19 results in increased locomotor activity and muscle strength, as well as improvements in key muscle and bone parameters, along with a reduction in very small muscle fibers.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

Article Multidisciplinary Sciences

Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice

Nadejda Bozadjieva-Kramer et al.

Summary: Intestinal FGF15 plays a crucial role in weight control, bone protection, and glucose tolerance after vertical sleeve gastrectomy (VSG). Knockout of FGF15 in mice leads to more adverse effects during VSG, indicating the importance of FGF15 in post-surgery outcomes.

NATURE COMMUNICATIONS (2021)

Article Medicine, Research & Experimental

Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts

Subrata Chowdhury et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Transplantation

Contribution of uremic dysbiosis to insulin resistance and sarcopenia

Kiyotaka Uchiyama et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2020)

Article Multidisciplinary Sciences

Curtailing FGF19's mitogenicity by suppressing its receptor dimerization ability

Jianlou Niu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Biochemistry & Molecular Biology

Effect of skeletal muscle phenotype and gender on fasting-induced myokine expression in mice

Wei-hua Jia et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Chronic kidney disease exacerbates ischemic limb myopathy in mice via altered mitochondria! energetics

Fabian N. Berru et al.

SCIENTIFIC REPORTS (2019)

Review Urology & Nephrology

The Klotho proteins in health and disease

Makoto Kuro-o

NATURE REVIEWS NEPHROLOGY (2019)

Article Physiology

Chronic Kidney Disease Is Associated with Increased Plasma Levels of Fibroblast Growth Factors 19 and 21

Malgorzata Marchelek-Mysliwiec et al.

KIDNEY & BLOOD PRESSURE RESEARCH (2019)

Article Immunology

Factors Related to Osteosarcopenia in Kidney Transplant Recipients

M. Yanishi et al.

TRANSPLANTATION PROCEEDINGS (2018)

Article Biochemistry & Molecular Biology

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

Berengere Benoit et al.

NATURE MEDICINE (2017)

Review Biotechnology & Applied Microbiology

Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23

Chiara Degirolamo et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Medicine, Research & Experimental

Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease

Laetitia Koppe et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Review Urology & Nephrology

Probiotics and chronic kidney disease

Laetitia Koppe et al.

KIDNEY INTERNATIONAL (2015)

Article Urology & Nephrology

A Pegylated Leptin Antagonist Ameliorates CKD-Associated Cachexia in Mice

Wai W. Cheung et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

Review Urology & Nephrology

Mechanisms of muscle wasting in chronic kidney disease

Xiaonan H. Wang et al.

NATURE REVIEWS NEPHROLOGY (2014)

Article Multidisciplinary Sciences

Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia

Ananda Chapagain et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Physiology

Effect of chronic renal failure on the hepatic, intestinal, and renal expression of bile acid transporters

Zhibo Gai et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2014)

Article Urology & Nephrology

p-Cresyl Sulfate Promotes Insulin Resistance Associated with CKD

Laetitia Koppe et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)

Article Physiology

Metabolic and morphometric profile of muscle fibers in chronic hemodialysis patients

Michael I. Lewis et al.

JOURNAL OF APPLIED PHYSIOLOGY (2012)

Review Endocrinology & Metabolism

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Bente K. Pedersen et al.

NATURE REVIEWS ENDOCRINOLOGY (2012)

Article Transplantation

OPPORTUNITY™: a large-scale randomized clinical trial of growth hormone in hemodialysis patients

Joel D. Kopple et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2011)

Article Endocrinology & Metabolism

Fibroblast Growth Factor 19 Serum Levels: Relation to Renal Function and Metabolic Parameters

M. Reiche et al.

HORMONE AND METABOLIC RESEARCH (2010)

Article Medicine, General & Internal

Frailty and Chronic Kidney Disease: The Third National Health and Nutrition Evaluation Survey

Emilee R. Wilhelm-Leen et al.

AMERICAN JOURNAL OF MEDICINE (2009)

Editorial Material Endocrinology & Metabolism

Beyond FRAX (R): It's Time to Consider Sarco-Osteopenia

Neil Binkley et al.

JOURNAL OF CLINICAL DENSITOMETRY (2009)

Article Urology & Nephrology

Effects of body size and body composition on survival in hemodialysis patients

S Beddhu et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)