4.7 Article

Integration analysis of miRNA-mRNA expression exploring their potential roles in intrahepatic cholangiocarcinoma

期刊

SCIENTIFIC REPORTS
卷 13, 期 1, 页码 -

出版社

NATURE PORTFOLIO
DOI: 10.1038/s41598-023-35288-0

关键词

-

向作者/读者索取更多资源

An integrative analysis of differentially expressed genes (DEGs) and miRNAs from ICC onset and adjacent normal tissues was conducted to explore the regulatory roles of miRNA-mRNA interaction. A total of 1018 DEGs and 39 miRNAs were found to be likely involved in ICC pathogenesis, indicating alterations in cell metabolism during ICC development. The network analysis revealed that 30 DEGs were regulated by 16 differentially expressed miRNAs. The identified DEGs and miRNAs may serve as biomarkers for ICC, highlighting their potential importance in ICC pathogenesis. This study provides a solid foundation for understanding the regulatory mechanism of miRNAs and mRNAs in ICC pathogenesis.
Intrahepatic cholangiocarcinoma (ICC) is the second common primary hepatic malignancy tumor. In this study, an integrative analysis of differentially expressed genes (DEGs) and miRNAs from the ICC onset and adjacent normal tissues were performed to explore the regulatory roles of miRNA-mRNA interaction. A total of 1018 DEGs and 39 miRNAs were likely involved in ICC pathogenesis, suggesting the changes in cell metabolism in ICC development. The built network indicated that 30 DEGs were regulated by 16 differentially expressed miRNA. The screened DEGs and miRNA together were probably considered the biomarkers of ICC, and their important roles in ICC pathogenesis remain to be elucidated. This study could provide a good basis to uncover the regulatory mechanism of miRNA and mRNAs in ICC pathogenesis.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据