Metabolic profiles of lung adenocarcinoma via peripheral blood and diagnostic model construction

The metabolic profile of cancerous cells is shifted to meet the cellular demand required for proliferation and growth. Here we show the features of cancer metabolic profiles using peripheral blood of healthy control subjects (n = 78) and lung adenocarcinoma (LUAD) patients (n = 64). Among 121 detected metabolites, diagnosis of LUAD is based on arginine, lysophosphatidylcholine-acyl (Lyso.PC.a) C16:0, and PC-diacyl (PC.aa) C38:3. Network analysis revealed that network heterogeneity, diameter, and shortest path were decreased in LUAD. On the contrary, these parameters were increased in advanced-stage compared to early-stage LUAD. Clustering coefficient, network density, and average degree were increased in LUAD compared to the healthy control, whereas these topologic parameters were decreased in advanced-stage compared to early-stage LUAD. Public LUAD data verified that the genes encoding enzymes for arginine (NOS, ARG, AZIN) and for Lyso.PC and PC (CHK, PCYT, LPCAT) were related with overall survival. Further studies are required to verify these results with larger samples and other histologic types of lung cancer.

Automated summary

This study investigates the metabolic profiles of lung adenocarcinoma (LUAD) patients and identifies specific metabolites, such as arginine and lysophosphatidylcholine-acyl (Lyso.PC.a) C16:0, that are associated with LUAD diagnosis. Network analysis reveals distinct changes in network properties between early-stage and advanced-stage LUAD. These findings suggest the potential of metabolites and network analysis as biomarkers for LUAD diagnosis and prognosis.