Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development

It is known to all that Wnt signaling pathway plays an important role in the early development of tooth. Our previous research found that Wnt signaling pathway played crucial roles in dental development, and mutations in antagonist of Wnt signaling pathway may lead to the formation of supernumerary teeth. However, the expression pattern of Wnt signaling molecules in early development of tooth, especially genes with stage specificity, remains unclear. Hence, we applied RNA-seq analysis to determine the expression levels of wnt signal molecules at five different stages of rat first molar tooth germ. In addition, after literature review we summarized the function of Wnt signaling molecules during tooth development and the relationship between Wnt signaling molecules variation and tooth agenesis. Our research may have implications for exploring the role of Wnt signaling molecules in different stages of tooth development.

Automated summary

It has been found that the Wnt signaling pathway plays a crucial role in the early development of teeth and mutations in Wnt signaling pathway antagonists may result in supernumerary teeth. However, the expression pattern of Wnt signaling molecules, especially stage-specific genes, during tooth development remains unclear. Therefore, we used RNA-seq analysis to determine the expression levels of Wnt signal molecules at five different stages of rat first molar tooth germ. Additionally, through literature review, we summarized the function of Wnt signaling molecules during tooth development and their relationship with tooth agenesis. Our study may have important implications for understanding the role of Wnt signaling molecules in different stages of tooth development.