4.7 Article

Association between Genetic Variation in the TAS2R38 Bitter Taste Receptor and Propylthiouracil Bitter Taste Thresholds among Adults Living in Japan Using the Modified 2AFC Procedure with the Quest Method

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NUTRIENTS
卷 15, 期 10, 页码 -

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MDPI
DOI: 10.3390/nu15102415

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TAS2R38; bitter taste; PROP; genetic polymorphisms; QUEST method; Bayesian procedure; two-alternative forced-choice (2AFC) procedure

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Individual taste sensitivity has a significant impact on food preferences, nutritional control, and health, and varies greatly between individuals. This study aimed to develop a method for measuring and quantifying taste sensitivity, and to explore the relationship between taste variation and genetic polymorphisms in humans using TAS2R38 bitter taste receptor gene and PROP compound. The study found significant differences in PROP threshold between different TAS2R38 genotypes, and individuals with specific genotypes were found to be much more sensitive to PROP bitterness. The findings provide a basis for accurately estimating taste thresholds using the modified 2AFC with the QUEST approach.
Individual taste sensitivity influences food preferences, nutritional control, and health, and differs greatly between individuals. The purpose of this study was to establish a method of measuring and quantifying an individual's taste sensitivity and to evaluate the relationship between taste variation and genetic polymorphisms in humans using agonist specificities of the bitter taste receptor gene, TAS2R38, with the bitter compound 6-n-propylthiouracil (PROP). We precisely detected the threshold of PROP bitter perception by conducting the modified two-alternative forced-choice (2AFC) procedure with the Bayesian staircase procedure of the QUEST method and examined genetic variation in TAS2R38 in a Japanese population. There were significant differences in PROP threshold between the three TAS2R38 genotype pairs for 79 subjects: PAV/PAV vs AVI/AVI, p < 0.001; PAV/AVI vs AVI/AVI, p < 0.001; and PAV/PAV vs PAV/AVI, p < 0.01. Our results quantified individual bitter perception as QUEST threshold values: the PROP bitter perception of individuals with the PAV/PAV or PAV/AVI genotypes was tens to fifty times more sensitive than that of an individual with the AVI/AVI genotype. Our analyses provide a basic model for the accurate estimation of taste thresholds using the modified 2AFC with the QUEST approach.

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