Two Faces of Catechol-O-Methyltransferase Inhibitor on One-Carbon Metabolism in Parkinson's Disease: A Meta-Analysis

Review Pharmacology & Pharmacy

Molecular Mechanisms and Therapeutic Strategies for Levodopa-Induced Dyskinesia in Parkinson's Disease: A Perspective Through Preclinical and Clinical Evidence

Ritam Bandopadhyay et al.

Summary: This study focuses on the recent updates in molecular mechanisms and therapeutic approaches for the effective management of levodopa-induced dyskinesia (LID) in Parkinson's disease patients.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Cell Biology

Impairment of neuronal mitochondrial function by l-DOPA in the absence of oxygen-dependent auto-oxidation and oxidative cell damage

Philipp Hoermann et al.

Summary: l-DOPA, the most commonly used drug for treating symptoms of Parkinson's disease, can be enzymatically converted to dopamine to restore depleted neurotransmitter levels. Research has shown that oxygen tensions comparable to those in the mammalian brain can significantly inhibit l-DOPA auto-oxidation and even enhance its ability to scavenge reactive oxygen species. This study further revealed that l-DOPA reprograms mitochondrial metabolism, reducing oxidative phosphorylation and inducing reductive glutamine metabolism, shedding new light on its cellular effects and neuro-toxicity under physiological oxygen levels.

CELL DEATH DISCOVERY (2021)

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Article Orthopedics

Low serum vitamin B12 levels are associated with degenerative rotator cuff tear

Jae Hwa Kim et al.

Summary: The study found that low serum levels of Vitamin B-12 were independently associated with degenerative rotator cuff tears. Further research is needed to determine if Vitamin B-12 supplementation can reduce the risk of this condition.

BMC MUSCULOSKELETAL DISORDERS (2021)

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Article Clinical Neurology

Different Catechol-O-Methyl Transferase Inhibitors in Parkinson's Disease: A Bayesian Network Meta-Analysis

Zhaoming Song et al.

Summary: The study findings indicate that opicapone showed higher efficiency and fewer safety problems in the five selected indicators when treating patients with PD, compared to the other two drugs.

FRONTIERS IN NEUROLOGY (2021)

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Article Public, Environmental & Occupational Health

Global Trends in the Incidence, Prevalence, and Years Lived With Disability of Parkinson's Disease in 204 Countries/Territories From 1990 to 2019

Zejin Ou et al.

Summary: The incidence, prevalence, and years lived with disability (YLDs) of Parkinson's disease (PD) have shown increasing trends globally from 1990 to 2019. Most regions and countries have observed an upward trend in the burden of PD, particularly in relation to the aging population.

FRONTIERS IN PUBLIC HEALTH (2021)

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Article Clinical Neurology

Effects of vitamin B12, folate, and entacapone on homocysteine levels in levodopa-treated Parkinson's disease patients: A randomized controlled study

Chumpol Anamnart et al.

Summary: In this study, levodopa-treated Parkinson's disease patients had higher plasma homocysteine (Hcy) levels compared to levodopa-naive patients. Supplementation with vitamin B12 and folate significantly reduced Hcy levels, while entacapone showed only mild effects and was not statistically significant. Monitoring of Hcy levels and supplementation with inexpensive vitamin B12 and folate is recommended for levodopa-treated patients.

JOURNAL OF CLINICAL NEUROSCIENCE (2021)

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Review Medicine, General & Internal

Elevated homocysteine levels in patients with heart failure A systematic review and meta-analysis

Nake Jin et al.

Summary: This study conducted a meta-analysis and systematic review to examine the association between elevated plasma homocysteine (Hcy) levels and heart failure (HF). The results confirmed that HF patients had significantly higher Hcy levels compared to control subjects, with a positive relationship to the advancement of New York Heart Association (NYHA) class. Subgroup analyses also supported these findings.

MEDICINE (2021)

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Article Clinical Neurology

Plasma homocysteine, folate and vitamin B12 levels in Parkinson's disease in China: A meta-analysis

Bao Dong et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2020)

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Review Nutrition & Dietetics

Vitamin B6, vitamin B12 and methionine and risk of pancreatic cancer: a meta-analysis

Dan-Hong Wei et al.

NUTRITION JOURNAL (2020)

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Review Clinical Neurology

Role of homocysteine in the development and progression of Parkinson's disease

Xiaoyan Fan et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)

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Review Nutrition & Dietetics

The role of one-carbon metabolism and homocysteine in Parkinson's disease onset, pathology and mechanisms

Lauren K. Murray et al.

NUTRITION RESEARCH REVIEWS (2019)

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Review Biochemistry & Molecular Biology

Dopamine and Levodopa Prodrugs for the Treatment of Parkinson's Disease

Fatma Haddad et al.

MOLECULES (2018)

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Review Biotechnology & Applied Microbiology

Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs

Delphine Charvin et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

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Review Nutrition & Dietetics

The metabolism and significance of homocysteine in nutrition and health

Avinash Kumar et al.

NUTRITION & METABOLISM (2017)

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Article Clinical Neurology

Effects of Homocysteine on white matter diffusion parameters in Alzheimer's disease

Chen-Chang Lee et al.

BMC NEUROLOGY (2017)

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Review Nutrition & Dietetics

B Vitamins and the Brain: Mechanisms, Dose and Efficacy-A Review

David O. Kennedy

NUTRIENTS (2016)

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Review Pharmacology & Pharmacy

Homocysteine excess: delineating the possible mechanism of neurotoxicity and depression

Pankaj Bhatia et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2015)

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Review Nutrition & Dietetics

Role of homocysteine in the development of cardiovascular disease

Paul Ganguly et al.

NUTRITION JOURNAL (2015)

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Review Clinical Neurology

Elevated homocysteine levels in levodopa-treated idiopathic Parkinson's disease: a meta-analysis

X. -W. Hu et al.

ACTA NEUROLOGICA SCANDINAVICA (2013)

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Article Neurosciences

Coenzyme Q10, Hyperhomocysteinemia and MTHFR C677T Polymorphism in Levodopa-treated Parkinson's Disease Patients

Gaetano Gorgone et al.

NEUROMOLECULAR MEDICINE (2012)

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Article Multidisciplinary Sciences

Area-heterogeneity tradeoff and the diversity of ecological communities

Omri Allouche et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Clinical Neurology

Methylenetetrahydrofolate reductase polymorphisms and plasma homocysteine in levodopa-treated and non-treated Parkinson's disease patients

Rey-Yue Yuan et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2009)

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Article Clinical Neurology

Hyperhomocy steinemia in Levodopa-Treated Patients with Parkinson's Disease Dementia

Stefano Zoccolella et al.

MOVEMENT DISORDERS (2009)

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Letter Clinical Neurology

Effect of levodopa and entacapone treatment on plasma homocysteine levels in Parkinson's disease patients

M. Nevrly et al.

PARKINSONISM & RELATED DISORDERS (2009)

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Article Neurosciences

Effect of MTHFR polymorphisms on hyperhomocysteinemia in levodopa-treated Parkinsonian patients

D. Caccamo et al.

NEUROMOLECULAR MEDICINE (2007)

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Article Clinical Neurology

The influence of levodopa and the COMT inhibitor on serum vitamin B12 and folate levels in Parkinson's disease patients

N. I. Triantafyllou et al.

EUROPEAN NEUROLOGY (2007)

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Article Clinical Neurology

Plasma homocysteine levels in patients treated with levodopa: motor and cognitive associations

Feriha Ozer et al.

NEUROLOGICAL RESEARCH (2006)

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Article Clinical Neurology

Homocysteine serum levels and MTHFR C677T genotype in patients with Parkinson's disease, with and without levodopa therapy

Zoran Todorovic et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2006)

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Article Neurosciences

Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in patients with Parkinson's disease

D. Religa et al.

NEUROSCIENCE LETTERS (2006)

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Article Pharmacology & Pharmacy

Tolcapone decreases plasma levels of S-adenosyl-L-homocysteine and homocysteine in treated Parkinson's disease patients

T Müller et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2006)

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Article Clinical Neurology

Endothelial function markers in parkinsonian patients with hyperhomocysteinemia

S Bostantjopoulou et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2005)

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Article Clinical Neurology

Reduced plasma homocysteine levels in levodopa/entacapone treated Parkinson patients

P Valkovic et al.

PARKINSONISM & RELATED DISORDERS (2005)

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Article Clinical Neurology

Hyperhomocysteinemia in L-dopa treated Parkinson's disease patients: effect of cobalamin and folate administration

P Lamberti et al.

EUROPEAN JOURNAL OF NEUROLOGY (2005)

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Article Clinical Neurology

Plasma homocysteine levels in Parkinson's disease: role of antiparkinsonian medications

S Zoccolella et al.

PARKINSONISM & RELATED DISORDERS (2005)

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Article Clinical Neurology

Effects of levodopa and COMT inhibitors on plasma homocysteine in Parkinson's disease patients

P Lamberti et al.

MOVEMENT DISORDERS (2005)

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Article Clinical Neurology

Modest increase in plasma homocysteine follows levodopa initiation in Parkinson's disease

PE O'Suilleabhain et al.

MOVEMENT DISORDERS (2004)

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Article Clinical Neurology

Levodopa-associated increase of homocysteine levels and sural axonal neurodegeneration

T Müller et al.

ARCHIVES OF NEUROLOGY (2004)

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Article Medicine, General & Internal

Measuring inconsistency in meta-analyses

JPT Higgins et al.

BMJ-BRITISH MEDICAL JOURNAL (2003)

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Letter Clinical Neurology

Benefit of folic acid supplementation in parkinsonian patients treated with levodopa

T Müller et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2003)

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Article Neurosciences

Homocysteine and folate deficiency sensitize oligodendrocytes to the cell death-promoting effects of a presenilin-1 mutation and amyloid beta-peptide

KJ Pak et al.

NEUROMOLECULAR MEDICINE (2003)

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Review Medicine, General & Internal

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

DS Wald et al.

BMJ-BRITISH MEDICAL JOURNAL (2002)

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Article Neurosciences

Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease

II Kruman et al.

JOURNAL OF NEUROSCIENCE (2002)

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Article Clinical Neurology

COMT-inhibition increases serum levels of dihydroxyphenylacetic acid (DOPAC) in patients with advanced Parkinson's disease

M Oechsner et al.

JOURNAL OF NEURAL TRANSMISSION (2002)

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Article Clinical Neurology

Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD

K Yasui et al.

NEUROLOGY (2000)

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Two Faces of Catechol-O-Methyltransferase Inhibitor on One-Carbon Metabolism in Parkinson's Disease: A Meta-Analysis

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