4.7 Article

THC-Reduced Cannabis sativa L.-How Does the Solvent Determine the Bioavailability of Cannabinoids Given Orally?

期刊

NUTRIENTS
卷 15, 期 12, 页码 -

出版社

MDPI
DOI: 10.3390/nu15122646

关键词

endocannabinoid system; cannabidiol (CBD); tetrahydrocannabinol (THC); bioavailability; pharmacokinetics

向作者/读者索取更多资源

This study evaluated the bioavailability and stability of CBD and THC in an extract with reduced THC content derived from Cannabis sativa L. It was found that the CBD/THC ratio in the extract was 16:1, higher than typical medical preparations. The results showed higher concentrations of CBD than THC in the whole-blood and brain after oral administration, and the total bioavailability was higher for Rapae oleum compared to Cremophor.
The bioavailability levels of cannabidiol (CBD) and tetrahydrocannabinol (THC) determine their pharmacological effects. Therefore, for medical purposes, it is essential to obtain extracts containing the lowest possible content of the psychogenic component THC. In our extract, the CBD/THC ratio was 16:1, which is a high level compared to available medical preparations, where it is, on average, 1:1. This study assessed the bioavailability and stability of CBD and THC derived from Cannabis sativa L. with reduced THC content. The extract was orally administered (30 mg/kg) in two solvents, Rapae oleum and Cremophor, to forty-eight Wistar rats. The whole-blood and brain concentrations of CBD and THC were measured using liquid chromatography coupled with mass spectrometry detection. Much higher concentrations of CBD than THC were observed for both solvents in the whole-blood and brain after oral administration of the Cannabis sativa extract with a decreased THC content. The total bioavailability of both CBD and THC was higher for Rapae oleum compared to Cremophor. Some of the CBD was converted into THC in the body, which should be considered when using Cannabis sativa for medical purposes. The THC-reduced hemp extract in this study is a promising candidate for medical applications.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据