Nigella sativa???????-Floral Honey and Multi-Floral Honey versus Nigella sativa Oil against Testicular Degeneration Rat Model: The Possible Protective Mechanisms

Article Environmental Sciences

Impact of gervital against histopathological, ultrastructural, and biochemical alterations caused by methotrexate or azathioprine in albino rat testis

Manal Abdul-Hamid et al.

Summary: This study found that grape seed extract (GSE) can protect the testis from damage caused by Methotrexate (MTX) and azathioprine (AZA), and it has antioxidant effects.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2023)

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Article Pharmacology & Pharmacy

Protective Effect of Apis dorsata Honey on Chronic Monosodium Glutamate-Induced Testicular Toxicity in Mus musculus Mice

Epy Muhammad Luqman et al.

Summary: This study demonstrates the protective effect of Apis dorsata honey against testicular toxicity induced by monosodium glutamate (MSG) in mice, reducing Leydig cell necrosis count and malondialdehyde (MDA) serum level.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

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Article Veterinary Sciences

Promoting action of vitamin E and black seed oil on reproductive hormones and organ histoarchitecture of Swiss albino mice

Afrina Mustari et al.

Summary: The study demonstrated that black seed oil, vitamin E, or their combination have a promoting effect on the reproductive functions of mice, particularly significant impacts on the testes and ovaries. In male mice, black seed oil significantly increased the testosterone level, while the combination of vitamin E and black seed oil showed significant increase in thyroxin. However, in female mice, there were no significant changes in estradiol and thyroxin levels. Histomorphological examination of the ovaries revealed that mice fed with black seed oil, vitamin E, or both exhibited a higher number of follicles at different stages compared to the control group.

VETERINARY MEDICINE AND SCIENCE (2022)

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Article Pharmacology & Pharmacy

INTERVENTION OF MEDICINAL PLANTS FOR IMPROVING MALE FERTILITY

Kanan Gamanlal Gamit et al.

Summary: Sexuality is a multifaceted process influenced by anatomical, physiological, psychological, developmental, cultural, and relational factors. Male infertility is a global problem caused by various factors such as environmental, nutritional, and lifestyle-related reasons. Studies have shown that certain plants can increase testosterone levels and help with male sexual dysfunction.

PHARMACOPHORE (2022)

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Review Plant Sciences

Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic

Muhammad Fakhar-E-Alam Kulyar et al.

Summary: The world is facing a difficult time amid the COVID-19 pandemic, with urgency in developing a vaccine and finding suitable treatment options. Immune regulation is crucial in combating the virus, and Black seed has shown potential as an immune-modulator with anti-inflammatory and antioxidant benefits. Molecular studies suggest Black seed may have comparable or better effects than FDA approved drugs in combating COVID-19.

PHYTOMEDICINE (2021)

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Article Medicine, Research & Experimental

The effect of Nigella sativa oil and metformin on male seminal parameters and testosterone in Wistar rats exposed to an obesogenic diet

Kristian Leisegang et al.

Summary: Obesity is a significant risk factor for male reproductive dysfunction and infertility. Nigella sativa seed oil and metformin show potential positive effects on obesity, but further research is needed on their impact on male fertility.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Environmental Sciences

Evaluation of sex steroid hormones and reproductive irregularities in diethyl phthalate-exposed premature mice: modulatory effect of raw honey against potential anomalies

Chaman Ara et al.

Summary: This study investigated the reproductive damage induced by DEP and the therapeutic efficacy of raw honey in male albino mice. The results showed that mice exposed to DEP experienced various anomalies, but concurrent use of honey and DEP significantly improved the histopathological lesions. Honey demonstrated antioxidant potential in protecting against DEP-induced abnormalities in male mice.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

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Article Multidisciplinary Sciences

Antioxidant and cytoprotective effects of Nigellasativa L. seeds on the testis of monosodium glutamate challenged rats

Mahmoud Abd-Elkareem et al.

Summary: The study showed that Nigellasativa L. seeds could mitigate testicular impairment caused by monosodium glutamate through antioxidant and cytoprotective activities, alleviating histological disturbances in rats.

SCIENTIFIC REPORTS (2021)

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Article Medicine, General & Internal

Inhibitory effects of Nigella sativa seed oil on the testosterone-induced benign prostatic hyperplasia in rats

Arezo Sadeghimanesh et al.

Summary: The study found that oral treatment with N. sativa seed oil significantly reduced prostate index, volume, DHT concentration, PSA, and serum MDA levels, while also increasing serum antioxidant capacity. This suggests that the oil seed has anti-BPH effects, possibly due to its antioxidant properties.

BIOMEDICINE-TAIWAN (2021)

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Article Veterinary Sciences

Kaliandra honey improves testosterone levels, diameter and epithelial thickness of seminiferous tubule of white rat (Rattus norvegicus) due to malnutrition through stimulation of HSP70

Nefranindy Rahma et al.

Summary: This study demonstrated that Kaliandra honey at a dose of 50% (v/v) significantly improved testosterone levels, diameter, and epithelial thickness of the seminiferous tubule of malnourished rats by stimulating HSP70 expression.

OPEN VETERINARY JOURNAL (2021)

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Article Andrology

Hesperidin attenuated apoptotic-related genes in testicle of a male rat model of varicocoele

M. Shokoohi et al.

ANDROLOGY (2020)

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Article Environmental Sciences

Early prenatal exposure to suspected endocrine disruptor mixtures is associated with lower IQ at age seven

Eva M. Tanner et al.

ENVIRONMENT INTERNATIONAL (2020)

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Review Dermatology

Systemic medications used in treatment of common dermatological conditions: safety profile with respect to pregnancy, breast feeding and content in seminal fluid

Sarah Madeline Brown et al.

JOURNAL OF DERMATOLOGICAL TREATMENT (2019)

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Article Biochemistry & Molecular Biology

Honey attenuates the toxic effects of the low dose of tartrazine in male rats

Haddad A. El Rabey et al.

JOURNAL OF FOOD BIOCHEMISTRY (2019)

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Article Medicine, Research & Experimental

Candesartan in a rat model of testicular toxicity: New insight on its protective mechanism

Iman O. Sherif et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2019)

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Article Food Science & Technology

Melissopalynological, physicochemical and antioxidant properties of honey from West Coast of Malaysia

Kirthiga Selvaraju et al.

JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE (2019)

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Article Medicine, Research & Experimental

Thymoquinone attenuates testicular and spermotoxicity following subchronic lead exposure in male rats: Possible mechanisms are involved

Eman Hassan et al.

LIFE SCIENCES (2019)

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Review Andrology

Testosterone Is a Contraceptive and Should Not Be Used in Men Who Desire Fertility

Amir Shahreza Patel et al.

WORLD JOURNAL OF MENS HEALTH (2019)

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Review Multidisciplinary Sciences

Mechanisms of honey on testosterone levels

Saleem Ali Banihani

HELIYON (2019)

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Review Biochemistry & Molecular Biology

Medicinal and Therapeutic Potential of Herbs and Plant Metabolites / Extracts Countering Viral Pathogens - Current Knowledge and Future Prospects

Kuldeep Dhama et al.

CURRENT DRUG METABOLISM (2018)

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Article Integrative & Complementary Medicine

Ameliorative effect of taurine-chloramine in azathioprine-induced testicular damage; a deeper insight into the mechanism of protection

Mona F. Schaalan et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)

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Article Andrology

Honey improves spermatogenesis and hormone secretion in testicular ischaemia-reperfusion-induced injury in rats

M. Gholami et al.

ANDROLOGIA (2018)

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Article Agriculture, Multidisciplinary

Effect of black cumin seeds on growth performance, nutrient utilization, immunity, gut health and nitrogen excretion in broiler chickens

Pawan Kumar et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2017)

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Article Andrology

Protective effect of thymoquinone against testicular torsion induced oxidative injury

M. Ayan et al.

ANDROLOGIA (2016)

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Article Andrology

Mitigation of paracetamol-induced reproductive damage by chrysin in male rats via reducing oxidative stress

E. H. Aksu et al.

ANDROLOGIA (2016)

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Review Chemistry, Applied

Honey: Chemical composition, stability and authenticity

Priscila Missio da Silva et al.

FOOD CHEMISTRY (2016)

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Article Endocrinology & Metabolism

Sex Hormone Binding Globulin Modifies Testosterone Action and Metabolism in Prostate Cancer Cells

Huika Li et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2016)

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Article Multidisciplinary Sciences

Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis

Michael R. Laurent et al.

SCIENTIFIC REPORTS (2016)

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Article Anatomy & Morphology

The Effects of Curcumin on Sperm Parameters and Nitric Oxide Production in Varicocelized Rats

Melika Izadpanah et al.

INTERNATIONAL JOURNAL OF MORPHOLOGY (2015)

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Article Endocrinology & Metabolism

A unique view on male infertility around the globe

Ashok Agarwal et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2015)

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Review Integrative & Complementary Medicine

Effects of black seeds (Nigella sativa) on male infertility: A systematic review

Reza Mandavi et al.

JOURNAL OF HERBAL MEDICINE (2015)

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Article Public, Environmental & Occupational Health

The protective role of bee honey against the toxic effect of melamine in the male rat kidney

Madeha N. Al-Seeni et al.

TOXICOLOGY AND INDUSTRIAL HEALTH (2015)

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Editorial Material Endocrinology & Metabolism

REPRODUCTIVE ENDOCRINOLOGY Functional effects of sex hormone-binding globulin variants

Michael R. Laurent et al.

NATURE REVIEWS ENDOCRINOLOGY (2014)

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Article Plant Sciences

Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: A randomized, double-blind, placebo-controlled clinical trial

M. Kolahdooz et al.

PHYTOMEDICINE (2014)

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Article Andrology

Effect of different doses of Malaysian honey on reproductive parameters in adult male rats

M. Mohamed et al.

ANDROLOGIA (2012)

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Article Andrology

Beneficial effects of chrysin on the reproductive system of adult male rats

O. Ciftci et al.

ANDROLOGIA (2012)

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Review Reproductive Biology

Diverse Roles for Sex Hormone-Binding Globulin in Reproduction

Geoffrey L. Hammond

BIOLOGY OF REPRODUCTION (2011)

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Article Biochemistry & Molecular Biology

Antioxidant Protective Effect of Honey in Cigarette Smoke-Induced Testicular Damage in Rats

Mahaneem Mohamed et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2011)

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Article Andrology

Polyunsaturated Fatty Acids in Relation to Sperm Motility

H.P. NISSEN et al.

ANDROLOGIA (2010)

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Article Pharmacology & Pharmacy

Effects of pantothenic acid supplementation on adrenal steroid secretion from male rats

Sunkanya Jaroenporn et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2008)

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Article Endocrinology & Metabolism

Empirical estimation of free testosterone from testosterone and sex hormone-binding globulin immunoassays

LP Ly et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2005)

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Article Endocrinology & Metabolism

Genistein acutely stimulates nitric oxide synthesis in vascular endothelial cells by a cyclic adenosine 5′-monophosphate-dependent mechanism

DM Liu et al.

ENDOCRINOLOGY (2004)

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Article Pathology

Oxidation of biological systems: Oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification

A Nyska et al.

TOXICOLOGIC PATHOLOGY (2002)

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Article Neurosciences

Sex hormone binding globulin facilitates female sexual receptivity except when coupled to dihydrotestosterone

JD Caldwell et al.

BRAIN RESEARCH (2002)

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Nigella sativa???????-Floral Honey and Multi-Floral Honey versus Nigella sativa Oil against Testicular Degeneration Rat Model: The Possible Protective Mechanisms

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