期刊
NUTRIENTS
卷 15, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/nu15092173
关键词
shortened cervix; Lactobacillus; Gardenerella vaginalis; aerobic vaginitis; microbiome; risk in pregnancy
Cervical shortening is a known risk factor for preterm birth. The vaginal microbiome plays a crucial role in pregnancy and maternal and fetal outcomes. This study investigated the vaginal microbiome in women with a short cervix compared to those with a normal cervical length. The results showed that there were differences in the abundance of certain bacterial taxa between the two groups, with Staphylococcus and Pseudomonas being more common in women with a short cervix.
Cervical shortening is a recognised risk factor for pre-term birth. The vaginal microbiome plays an essential role in pregnancy and in maternal and foetal outcomes. We studied the vaginal microbiome in 68 women with singleton gestation and a cervical length =25 mm and in 29 pregnant women with a cervix >25 mm in the second or early third trimester. Illumina protocol 16S Metagenomic Sequencing Library Preparation was used to detail amplified 16SrRNA gene. Statistical analyses were performed in R environment. Firmicutes was the phylum most represented in all pregnant women. The mean relative abundance of Proteobacteria and Actinobacteriota was higher in women with a short cervix. Bacterial abundance was higher in women with a normal length cervix compared to the group of women with a short cervix. Nonetheless, a significant enrichment in bacterial taxa poorly represented in vaginal microbiome was observed in the group of women with a short cervix. Staphylococcus and Pseudomonas, taxa usually found in aerobic vaginitis, were more common in women with a short cervix compared with the control group, while Lactobacillus iners and Bifidobacterium were associated with a normal cervical length. Lactobacillus jensenii and Gardenerella vaginalis were associated with a short cervix.
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