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Article Medicine, Research & Experimental

Quercetin potentiates the hepatoprotective effect of sildenafil and/or pentoxifylline against intrahepatic cholestasis: Role of Nrf2/ARE, TLR4/NF-κB, and NLRP3/IL-1β signaling pathways

Michael A. Fawzy et al.

Summary: This study aimed to investigate the regulatory effects of quercetin (QU) on selected phosphodiesterase inhibitors against alpha-naphthyl isothiocyanate (ANIT)-induced acute intrahepatic cholestasis. The combination treatment of QU with sildenafil (Sild) or pentoxifylline (PTX) showed promising hepatoprotective effects and anti-cholestatic properties in improving ANIT-induced liver injury.

LIFE SCIENCES (2023)

Article Cell Biology

Plantain-based diet decreases oxidative stress and inflammatory markers in the testes of rats exposed to atrazine

Damilare Emmanuel Rotimi et al.

Summary: Exposure to the herbicide atrazine has detrimental effects on male fertility, but a plantain-based diet (PBD) can protect against these effects. A study on rat testes exposed to atrazine found that PBD restored oxidative and inflammatory parameters. The diet contained 16 bioactive compounds, with quercetin being the most prominent.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2023)

Review Pharmacology & Pharmacy

Protective Effects and Mechanisms of Flavonoids in Renal Ischemia-Reperfusion Injury

Peng Peng et al.

Summary: Flavonoids have been shown to have a protective effect against renal ischemia-reperfusion injury by alleviating oxidative stress, inflammation, cell death, endoplasmic reticulum stress, and mitochondrial dysfunction. However, the clinical application of flavonoids in this context still faces challenges.

PHARMACOLOGY (2023)

Article Agriculture, Multidisciplinary

Quercetin inhibits testicular toxicity induced by the mixture of three commonly used phthalates in rats

Ling-Zi Xia et al.

Summary: The study demonstrates that phthalates have toxic effects on the testicles, while quercetin can alleviate this toxicity, possibly through the regulation of steroid hormone metabolism.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2023)

Article Medicine, Research & Experimental

Induction of autophagy via the PI3K/Akt/mTOR signaling pathway by Pueraria flavonoids improves non-alcoholic fatty liver disease in obese mice

Chunbin Sun et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common lipid metabolism disorder. Autophagy plays a crucial role in lipid metabolism in NAFLD. Pueraria flavonoids, the main active components of Pueraria lobata, have antioxidant and anti-inflammatory effects. This study demonstrates that Pueraria flavonoids can reduce intracellular lipid accumulation and inflammation levels in NAFLD by stimulating autophagy through the PI3K/Akt/mTOR signaling pathway.

BIOMEDICINE & PHARMACOTHERAPY (2023)

Article Andrology

Cyclophosphamide-induced testicular oxidative-inflammatory injury is accompanied by altered immunosuppressive indoleamine 2, 3-dioxygenase in Wister rats: Influence of dietary quercetin

Azubuike Peter Ebokaiwe et al.

Summary: The study showed that quercetin significantly protected rat testicular function and prevented oxidative stress and inflammation caused by cyclophosphamide. Co-administration of quercetin reduced inflammatory factors and oxidative stress markers, increased testosterone levels, hormonal activities, and sperm quality.

ANDROLOGIA (2022)

Article Environmental Sciences

Glyphosate-induced gut microbiota dysbiosis facilitates male reproductive toxicity in rats

Jing-Bo Liu et al.

Summary: Glyphosate (GLY) exposure can lead to male reproductive toxicity by causing gut microbiota dysbiosis, affecting testis structure and sperm quality, and triggering IL-17A signaling pathway activation and testicular oxidative damage.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Review Andrology

Exploring the role of gut microbiome in male reproduction

Yan Wang et al.

Summary: This article reviews the possible mechanisms and therapeutic opportunities related to the impact of the gut microbiome on male reproduction, and emphasizes the need for further research in the future.

ANDROLOGY (2022)

Review Food Science & Technology

Design and optimization of quercetin-based functional foods

Wing-Fu Lai et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

Review Food Science & Technology

Absorption, metabolism and bioavailability of flavonoids: a review

Lei Chen et al.

Summary: Flavonoids, widely distributed in various plants and foods, have shown potential in preventing and treating various diseases. Research is focused on their absorption, metabolism, and application, with emphasis on the importance of nanoparticle delivery systems in enhancing their bioavailability.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

Review Biochemistry & Molecular Biology

Health Benefits of Quercetin in Age-Related Diseases

Deepika et al.

Summary: Polyphenols, including the widely occurring quercetin, are a group of plant compounds with antioxidant properties that protect against aging and various age-related diseases. Quercetin, present in abundant quantities in nature and particularly in onions, possesses antioxidant, anti-inflammatory, anti-carcinogenic, and anti-diabetic properties. It can easily cross the blood-brain barrier and has shown potential as a curative agent in neurodegeneration, diabetes, cancer, and inflammation. Further studies and formulations of quercetin could explore its potential in treating other age-associated diseases.

MOLECULES (2022)

Review Biochemistry & Molecular Biology

Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin

Aseel Ali Hasan et al.

Summary: This article analyzes the effects of quercetin and curcumin in cancer treatment, highlighting their roles in regulating signaling pathways and influencing non-coding RNA. Additionally, the therapeutic potential of quercetin and curcumin in diabetes, obesity, inflammation, and bacterial infections is discussed.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Quercetin Ameliorates Testicular Damage in Zucker Diabetic Fatty Rats through Its Antioxidant, Anti-Inflammatory and Anti-Apoptotic Properties

Eva Tvrda et al.

Summary: The aim of this study is to investigate the effects of quercetin on testicular architecture and markers of oxidative, inflammatory, and apoptotic profile in Zucker diabetic fatty rats with Type 2 diabetes mellitus. The results showed that quercetin improved testicular appearance, stabilized antioxidant capacity, decreased lipid peroxidation, and reduced inflammation levels.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Food Science & Technology

Dietary flavonoids prevent diabetes through epigenetic regulation: advance and challenge

Shuai Han et al.

Summary: Epigenetics plays a crucial role in exploring the etiology and treatment of diabetes, and reversing epigenetic alterations may reduce the burden of the disease. Dietary flavonoids as natural epigenetic modulators can serve as biomarkers for diabetes prevention and the development of alternative therapies. Further research is needed to explore the potential anti-diabetic effects of different flavonoids with various epigenetic regulation mechanisms through clinical trials.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

Article Environmental Sciences

Role of endoplasmic reticulum stress in cadmium-induced hepatocyte apoptosis and the protective effect of quercetin

Jicang Wang et al.

Summary: This study aimed to determine the protective effect of quercetin (Que) on cadmium (Cd)-induced hepatotoxicity. Through in vivo and in vitro experiments using rat models, the researchers found that Cd caused liver injury and cell apoptosis, and activated endoplasmic reticulum stress (ERS) signaling pathways. However, Que was able to improve hepatocyte vitality, reduce liver damage and oxidative stress caused by Cd.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Article Environmental Sciences

Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats

Ruijing Liu et al.

Summary: This study investigates the impact of BPA on male reproductive toxicity and its potential link to gut microbiota dysbiosis. The results show that BPA exposure damages testicular histology, decreases sperm count, and increases sperm abnormalities. Additionally, BPA exposure induces oxidative stress and cell apoptosis in the testes.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Article Reproductive Biology

Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells

Yun Chen et al.

Summary: This study aimed to explore the protective role of quercetin in cyclophosphamide-induced ovarian dysfunction and its underlying mechanism. The results showed that quercetin protected the ovarian reserve by reversing mitochondrial dysfunction and activating mitochondrial biogenesis via the PGC1-alpha pathway. Additionally, quercetin improved ovarian functions by downregulating pyroptosis.

JOURNAL OF OVARIAN RESEARCH (2022)

Review Cell Biology

Mechanisms of Cadmium-Induced Testicular Injury: A Risk to Male Fertility

Waseem Ali et al.

Summary: Cadmium is a toxic metal with unknown biological functions in the human body. It accumulates in different visceral organs over time and impairs their functions, especially in the testes. Cadmium damages Sertoli cells, seminiferous tubules, and the Blood Testis Barrier, leading to sperm loss. It also hinders the development and function of Leydig cells, and disrupts the vascular system of the testes. In addition, cadmium affects somatic cells and germ cells through epigenetic regulation, resulting in infertility or subfertility in males.
Article Biochemistry & Molecular Biology

Quercetin-Rich Ethanolic Extract of Polygonum odoratum var Pakphai Leaves Decreased Gene Expression and Secretion of Pro-Inflammatory Mediators in Lipopolysaccharide-Induced Murine RAW264.7 Macrophages

Nittaya Chansiw et al.

Summary: The ethanolic extract of P. odoratum var. Pakphai, rich in quercetin and other compounds, was found to exhibit anti-inflammatory activity by inhibiting the production of nitric oxide and inflammatory mediators in LPS-induced RAW264.7 cells.

MOLECULES (2022)

Review Biochemistry & Molecular Biology

Cellular senescence and senolytics: the path to the clinic

Selim Chaib et al.

Summary: Cellular senescence has emerged as a promising therapeutic target for disorders across the lifespan; targeting persistent senescent cells causing tissue damage may delay, prevent, or alleviate multiple diseases.

NATURE MEDICINE (2022)

Review Nutrition & Dietetics

Promising bioactive properties of quercetin for potential food applications and health benefits: A review

Irtiqa Shabir et al.

Summary: Quercetin and its derivatives are naturally occurring phytochemicals with promising biological properties, including anticancer, antidiabetic, and antibacterial effects. They can be found in fruits, vegetables, and coffee, and consuming them as part of a meal or as a supplement may benefit one's health.

FRONTIERS IN NUTRITION (2022)

Article Environmental Sciences

Palliative Effect of Resveratrol against Nanosized Iron Oxide-Induced Oxidative Stress and Steroidogenesis-Related Genes Dysregulation in Testicular Tissue of Adult Male Rats

Mona M. Ahmed et al.

Summary: This study found that resveratrol can significantly improve the impaired sperm quality caused by iron oxide nanoparticles. Additionally, resveratrol can counteract the inhibitory effects of iron oxide nanoparticles on sperm motility and viability, restore the reduced levels of sexual hormones and testicular injury caused by iron oxide nanoparticles, and reduce lipid peroxidation. Furthermore, resveratrol can significantly reverse the downregulation of steroidogenesis-related genes in testicular tissue caused by iron oxide nanoparticles.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

Article Pharmacology & Pharmacy

Protective effect of quercetin on cadmium-induced renal apoptosis through cyt-c/caspase-9/caspase-3 signaling pathway

Ruxue Huang et al.

Summary: Cadmium induces kidney injury and apoptosis, while Quercetin reduces kidney damage caused by Cadmium by decreasing oxidative stress and inhibiting apoptosis.

FRONTIERS IN PHARMACOLOGY (2022)

Review Immunology

Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism

Zhifu Cui et al.

Summary: Quercetin, a naturally non-toxic flavonoid, has antioxidant and anti-inflammatory properties and plays an important role in the treatment of aging-related diseases. SIRT1, extensively explored as a potential therapeutic target, has beneficial effects against aging-related diseases. This review summarizes the role of SIRT1 in the improvement of the attenuation effect of quercetin on aging-related diseases and the relationship between relevant signaling pathways regulated by SIRT1.

FRONTIERS IN IMMUNOLOGY (2022)

Article Biochemistry & Molecular Biology

Quercetin Attenuates Quinocetone-Induced Cell Apoptosis In Vitro by Activating the P38/Nrf2/HO-1 Pathway and Inhibiting the ROS/Mitochondrial Apoptotic Pathway

Chongshan Dai et al.

Summary: This study reveals that quercetin can protect human cells from damage caused by quinocetone (QCT) through activating the p38/Nrf2/HO-1 pathway and inhibiting the ROS/mitochondrial apoptotic pathway.

ANTIOXIDANTS (2022)

Article Integrative & Complementary Medicine

Globularia alypum Extracts Attenuate Hyperglycemia and Protect against Various Organ Toxicities in Alloxan-Induced Experimental Diabetic Rats

Mohamed Tiss et al.

Summary: This study analyzed the chemical composition and biopharmaceutical properties of Globaluria alypum extracts for the first time. The extracts showed potential antidiabetic effects by lowering blood glucose, protecting pancreatic beta-cells, increasing liver glycogen, and improving glucose tolerance. They also reduced weight loss and protected organs from diabetes-induced toxicities.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

Article Biochemistry & Molecular Biology

Protective Effect of Portulaca oleracea on Streptozotocin-Induced Type I Diabetes-Associated Reproductive System Dysfunction and Inflammation

Hassan Rakhshandeh et al.

Summary: The study found that Portulaca oleracea extract has a protective effect on streptozotocin-induced type-I-diabetes-associated reproductive system dysfunction and inflammation in rats. It ameliorated various parameters and histopathological indexes' damage, indicating its potential use in managing diabetic-associated clinical complications.

MOLECULES (2022)

Article Reproductive Biology

Potential protective effect of quercetin on the male reproductive system against exposure of Wistar rats to crude oil vapor: Genetic, biochemical, and histopathological evidence

Kaveh Khazaeel et al.

Summary: Quercetin has a protective role in testicular toxicity induced by crude oil vapor, improving sperm parameters, antioxidant enzyme activities, histological indexes, and apoptotic gene expression. This suggests that quercetin has the potential to reduce the side effects of crude oil vapor on the male reproductive system.

REPRODUCTIVE TOXICOLOGY (2022)

Article Biochemistry & Molecular Biology

Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats

Amany Behairy et al.

Summary: This study investigated the effects of lead acetate and aluminum trioxide nanoparticles on testicular function, and the protective effects of quercetin. The results showed that exposure to these substances caused sperm abnormalities, oxidative stress, and histopathological changes in the testis. However, quercetin administration reversed these negative effects.

ANTIOXIDANTS (2022)

Review Biochemistry & Molecular Biology

Microorganisms in the reproductive system and probiotic's regulatory effects on reproductive health

Tao Feng et al.

Summary: The presence of microbial communities in the reproductive tract plays an important role in maintaining health and reproductive well-being. Intentional modulation through probiotics has been suggested as a strategy to enhance reproductive health and reduce the risk of diseases. Both male and female reproductive microbiota are associated with the health of couples, pregnancy outcomes, and offspring health. Probiotics have been shown to impact male fertility and the health of mothers and offspring, while also regulating the female reproductive tract and influencing offspring health. Additionally, the parental reproductive microbiota and probiotic intervention can influence infant gut colonization and immune development with potential health consequences.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2022)

Review Food Science & Technology

Targeting epigenetics in cancer: therapeutic potential of flavonoids

Haroon Khan et al.

Summary: Cancer is the leading cause of mortality worldwide, with therapeutic challenges such as non-compliance, side effects, and economic burdens. Plant-derived flavonoids are being studied for their epigenetic regulation of cancer, with different classes of flavonoids having varying mechanisms of action.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2021)

Review Chemistry, Medicinal

Flavonoids as antiobesity agents: A review

Ana T. Rufino et al.

Summary: Obesity is a global health issue with increasing prevalence leading to a rise in comorbidities and significant health and socioeconomic burdens. Pharmacotherapy for obesity is gaining attention as an adjunctive treatment, but current available approaches have limitations due to adverse effects or low efficacy. Natural products, particularly flavonoids, show promise in modulating obesity through various mechanisms such as reducing food intake, increasing energy expenditure, and modulating lipid metabolism.

MEDICINAL RESEARCH REVIEWS (2021)

Article Environmental Sciences

Quercetin antagonizes imidacloprid-induced mitochondrial apoptosis through PTEN/PI3K/AKT in grass carp hepatocytes

Zhiruo Miao et al.

Summary: The study demonstrates that quercetin can effectively antagonize Imidacloprid-induced mitochondrial apoptosis in grass carp hepatocytes by regulating the PTEN/PI3K/AKT pathway.

ENVIRONMENTAL POLLUTION (2021)

Review Medicine, General & Internal

Male infertility

Ashok Agarwal et al.

Summary: Infertility affects 8-12% of couples globally, with male factors contributing to around 50%. The causes of male infertility are diverse, requiring thorough evaluation to identify treatable or reversible factors. Semen analysis is key for evaluation, while advanced tests have been developed to investigate sperm quality and function.

LANCET (2021)

Article Chemistry, Medicinal

Effects of quercetin supplementation on inflammatory factors and quality of life in post-myocardial infarction patients: A double blind, placebo-controlled, randomized clinical trial

Fereshteh Dehghani et al.

Summary: The study found that quercetin supplementation (500 mg/day, 8 weeks) significantly increased total antioxidant capacity and improved the insecurity dimension of quality of life in post-myocardial infarction patients, but did not show significant effects on inflammatory factors, blood pressure, and other quality of life dimensions.

PHYTOTHERAPY RESEARCH (2021)

Article Medicine, Research & Experimental

Catalpol ameliorates diabetes-induced testicular injury and modulates gut microbiota

Yihui Zhu et al.

Summary: Catalpol can reduce indicators of testicular injury in diabetic mice, increase sperm count and motility, and reverse the decrease in levels of metabolic products like lactate. Additionally, catalpol can also regulate the dysbiosis of gut microbiota.

LIFE SCIENCES (2021)

Review Acoustics

Novel extraction, rapid assessment and bioavailability improvement of quercetin: A review

Muhammad Faisal Manzoor et al.

Summary: The review discusses the use of novel extraction and non-destructive assessment techniques in the extraction and identification of quercetin, highlighting benefits such as shorter extraction time, less organic solvent usage, environmentally friendly processes, non-interruptive assessment, and label-free identification. Quercetin demonstrates potential therapeutic properties, and innovative drug delivery strategies have been proposed to address its low bioavailability.

ULTRASONICS SONOCHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Protective Effect of Quercetin on Sodium Iodate-Induced Retinal Apoptosis through the Reactive Oxygen Species-Mediated Mitochondrion-Dependent Pathway

Yuan-Yen Chang et al.

Summary: Quercetin protects human retinal pigment epithelium cells from NaIO3-induced apoptosis by inhibiting reactive oxygen species production and reducing loss of mitochondrial membrane potential. Quercetin downregulates Bax, cleaved caspase-3, and cleaved PARP proteins while upregulating Bcl-2 expression through reduced PI3K and pAKT expressions in the apoptosis pathway.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Environmental Sciences

Quercetin mediated attenuation of cadmium-induced oxidative toxicity and apoptosis of spermatogenic cells in caprine testes in vitro

Jitender Kumar Bhardwaj et al.

Summary: The study revealed that quercetin has a significant protective effect against testicular toxicity induced by cadmium, reducing oxidative stress and restoring antioxidant status. The experiment further elucidated the potential benefits of quercetin in preventing or managing male reproductive toxicity caused by increasing cadmium contamination in the environment.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2021)

Review Urology & Nephrology

European Association of Urology Guidelines on Male Sexual and Reproductive Health: 2021 Update on Male Infertility

Suks Minhas et al.

Summary: The latest guidelines from the European Association of Urology recommend comprehensive urological evaluation for infertile men to identify and treat modifiable causes of infertility, as well as to monitor their risk for cardiovascular disease and cancer. However, there is still insufficient evidence to support the routine use of some treatments and surgical interventions in clinical practice.

EUROPEAN UROLOGY (2021)

Review Chemistry, Medicinal

Quercetin and metabolic syndrome: A review

Azar Hosseini et al.

Summary: Quercetin, as an important flavonoid, has potential effects in improving symptoms of metabolic syndrome, but further research and clinical trials are needed to determine its true clinical value.

PHYTOTHERAPY RESEARCH (2021)

Review Immunology

Potential Implications of Quercetin in Autoimmune Diseases

Pan Shen et al.

Summary: Autoimmune diseases are a global health problem characterized by immune system breakdown and dysregulation. Quercetin, a natural flavonoid found in fruits, herbs, and vegetables, has beneficial effects such as anti-inflammation, anti-oxidation, and neuroprotection. Studies have indicated that quercetin may have potential preventive and therapeutic effects on autoimmune diseases like rheumatoid arthritis and inflammatory bowel disease.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Protective Effect of Quercetin on Testis Structure and Apoptosis Against Lead Acetate Toxicity: an Stereological Study

Zahra Khodabandeh et al.

Summary: Exposure to lead acetate had toxic effects on testicular structure and activation of the apoptotic pathways, while co-administration of quercetin partially alleviated these adverse effects.

BIOLOGICAL TRACE ELEMENT RESEARCH (2021)

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A minireview of quercetin: from its metabolism to possible mechanisms of its biological activities

Hande Gul Ulusoy et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2020)

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The Effect of Lead Acetate and Quercetin on the Tight and Gap Junctions in the Mouse Testis

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Protective effect of quercetin on rat testes against cadmium toxicity by alleviating oxidative stress and autophagy

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Toxicological Effects of Cadmium on Mammalian Testis

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Evaluation of thestatus quoof polyphenols analysis: Part I-phytochemistry, bioactivity, interactions, and industrial uses

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Modulating the Blood-Testis Barrier Towards Increasing Drug Delivery

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The role of flavonoids in autoimmune diseases: Therapeutic updates

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Quercetin inhibits human metastatic ovarian cancer cell growth and modulates components of the intrinsic apoptotic pathway in PA-1 cell line

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The effect of quercetin on iron overload and inflammation in β-thalassemia major patients: A double-blind randomized clinical trial

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Quercetin protects human granulosa cells against oxidative stress via thioredoxin system

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Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats

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Effects of cyanidin-3-O-glucoside on 3-chloro-1,2-propanediol induced intestinal microbiota dysbiosis in rats

Guowei Chen et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

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Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells

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Theoretical Study of the Antioxidant Activity of Quercetin Oxidation Products

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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

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EBIOMEDICINE (2019)

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Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review

Constanze C. Maresch et al.

HUMAN REPRODUCTION UPDATE (2018)

Article Medicine, Research & Experimental

Dose-dependent ameliorative effects of quercetin and L-Carnitine against atrazine- induced reproductive toxicity in adult male Albino rats

Rabie L. Abdel Aziz et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Flavonoids and the gastrointestinal tract: Local and systemic effects

P. I. Oteiza et al.

MOLECULAR ASPECTS OF MEDICINE (2018)

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Linking sleep disturbance to idiopathic male infertility

Gaurie Palnitkar et al.

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Beneficial effects of quercetin on titanium dioxide nanoparticles induced spermatogenesis defects in mice

Layasadat Khorsandi et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2017)

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Polyphenols and Performance: A Systematic Review and Meta-Analysis

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SPORTS MEDICINE (2017)

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Chemoprotective role of quercetin in manganese-induced toxicity along the brain-pituitary-testicular axis in rats

Isaac A. Adedara et al.

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7-O-Geranylquercetin induces apoptosis in gastric cancer cells via ROS-MAPK mediated mitochondrial signaling pathway activation

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BIOMEDICINE & PHARMACOTHERAPY (2017)

Article Toxicology

Quercetin attenuates di-(2-ethylhexyl) phthalate-induced testicular toxicity in adult rats

M. F. Abd-Ellah et al.

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iTRAQ-based quantitative proteomic analysis of the anti-apoptotic effect of hyperin, which is mediated by Mcl-1 and Bid, in H2O2-injured EA.hy926 cells

Xiao-Xia Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

Article Biochemistry & Molecular Biology

Querectin Alleviates Zinc Oxide Nanoreprotoxicity in Male Albino Rats

Mohamed M. A. Hussein et al.

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Quercetin ameliorates liver injury induced with Tripterygium glycosides by reducing oxidative stress and inflammation

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CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2015)

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Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells

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Quercetin prevents docetaxel- induced testicular damage in rats

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Sarwat Jahan et al.

SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE (2015)

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Direct Binding of Bcl-2 Family Proteins by Quercetin Triggers Its Pro-Apoptotic Activity

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Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1

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Supplementation With Quercetin Attenuates 4-Nitrophenol-Induced Testicular Toxicity in Adult Male Mice

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Quercetin impairs the reproductive potential of male mice

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Protective effects of quercetin against apoptosis and oxidative stress in streptozotocin-induced diabetic rat testis

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Dietary Antioxidant, Quercetin, Protects Sertoli-Germ Cell Coculture from Atrazine-Induced Oxidative Damage

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Protective Effect of Quercetin on Cadmium-Induced Oxidative Toxicity on Germ Cells in Male Mice

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Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis

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CLINICAL NUTRITION (2011)

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Effects of Low Dose Quercetin: Cancer Cell-Specific Inhibition of Cell Cycle Progression

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Alleviative effects of quercetin and onion on male reproductive toxicity induced by diesel exhaust particles

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Multitargeted cancer prevention by quercetin

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CANCER LETTERS (2008)

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Polyphenolic phytochemicals - just antioxidants or much more?

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Quercetin reduces blood pressure in hypertensive subjects

Randi L. Edwards et al.

JOURNAL OF NUTRITION (2007)

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Quercetin, a flavonoid antioxidant, modulates endothelium-derived nitric oxide bioavailability in diabetic rat aortas

Ajay Machha et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2007)

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Increased cellular apoptosis after chronic aqueous exposure to nonylphenol and quercetin in adult medaka (Oryzias latipes)

LP Weber et al.

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S Benoff et al.

HUMAN REPRODUCTION UPDATE (2000)