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Quercetin is a natural flavonoid widely found in natural fruits and vegetables. Recent studies have shown that quercetin mediates multiple beneficial effects in a variety of organ damage and diseases, and is considered a healthcare supplement with health-promoting potential. Male infertility is a major health concern, and testicular damage from multiple causes is an important etiology. Previous studies have shown that quercetin has a protective effect on reproductive function. This may be related to the antioxidant, anti-inflammatory, and anti-apoptotic biological activities of quercetin. Therefore, this paper reviews the mechanisms by which quercetin exerts its pharmacological activity and its role in testicular damage induced by various etiologies. In addition, this paper compiles the application of quercetin in clinical trials, demonstrating its practical effects in regulating blood pressure and inhibiting cellular senescence in human patients. However, more in-depth experimental studies and clinical trials are needed to confirm the true value of quercetin for the prevention and protection against testicular injury.

Automated summary

Quercetin, a natural flavonoid found in fruits and vegetables, has been shown to have multiple beneficial effects in organ damage and diseases, making it a potential health-promoting supplement. Previous studies have demonstrated its protective effect on reproductive function, possibly due to its antioxidant, anti-inflammatory, and anti-apoptotic properties. This paper reviews the mechanisms and role of quercetin in testicular damage, as well as its application in clinical trials, showing its practical effects in regulating blood pressure and inhibiting cellular senescence. However, more in-depth studies and trials are needed to confirm its true value in preventing and protecting against testicular injury.