期刊
NUTRIENTS
卷 15, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/nu15102325
关键词
carotenoids; Asian women; gene expression; mood; physical activity; fecal microbiome
The study aimed to investigate the safety and pharmacokinetics of oral beta-cryptoxanthin supplementation over 8 weeks. The results showed that supplementation of 3 or 6 mg/day of beta-cryptoxanthin was safe and well tolerated in healthy women. There was a significant increase in plasma beta-cryptoxanthin concentration in the 6 mg/day group compared to the 3 mg/day group and placebo after 8 weeks, without impacting other carotenoids.
Background: beta-cryptoxanthin is a dietary carotenoid for which there have been few studies on the safety and pharmacokinetics following daily oral supplementation. Methods: 90 healthy Asian women between 21 and 35 years were randomized into three groups: 3 and 6 mg/day oral beta-cryptoxanthin, and placebo. At 2, 4, and 8 weeks of supplementation, plasma carotenoid levels were measured. The effects of beta-cryptoxanthin on blood retinoid-dependent gene expression, mood, physical activity and sleep, metabolic parameters, and fecal microbial composition were investigated. Results: beta-cryptoxanthin supplementation for 8 weeks (3 and 6 mg/day) was found to be safe and well tolerated. Plasma beta-cryptoxanthin concentration was significantly higher in the 6 mg/day group (9.0 +/- 4.1 mu mol/L) compared to 3mg/day group (6.0 +/- 2.6 mu mol/L) (p < 0.03), and placebo (0.4 +/- 0.1 mu mol/L) (p < 0.001) after 8 weeks. Plasma all-trans retinol, alpha-cryptoxanthin, alpha-carotene, beta-carotene, lycopene, lutein, and zeaxanthin levels were not significantly changed. No effects were found on blood retinol-dependent gene expression, mood, physical activity and sleep, metabolic parameters, and fecal microbial composition. Conclusions: Oral beta-cryptoxanthin supplementation over 8 weeks lead to high plasma concentrations of beta-cryptoxanthin, with no impact on other carotenoids, and was well tolerated in healthy women.
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